Search Results - "Otrocka, M."

Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration by Pettersson-Klein, A.T., Izadi, M., Ferreira, D.M.S., Cervenka, I., Correia, J.C., Martinez-Redondo, V., Southern, M., Cameron, M., Kamenecka, T., Agudelo, L.Z., Porsmyr-Palmertz, M., Martens, U., Lundgren, B., Otrocka, M., Jenmalm-Jensen, A., Griffin, P.R., Ruas, J.L.

“…The peroxisome proliferator-activated receptor-γ coactivator-1α1 (PGC-1α1) regulates genes involved in energy metabolism. Increasing adipose tissue energy…”
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CXCR4 Antagonists: A Screening Strategy for Identification of Functionally Selective Ligands by Castaldo, C, Benicchi, T, Otrocka, M, Mori, E, Pilli, E, Ferruzzi, P, Valensin, S, Diamanti, D, Fecke, W, Varrone, M, Porcari, V

“…The CXC chemokine receptor 4 (CXCR4) is a widely expressed G protein-coupled receptor implicated in several diseases. In cancer, an increased number of surface…”
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417 (PB405): Exploring Synthetic Lethality and novel drug combinations in Patient-Derived Cells by Dulęba, M., Zimoląg, E., Szuszkiewicz, J., Serocki, M., Krawczyk, J., Bryzghalov, O., Stachowicz, A., Wieęckowska, I., Chmiel, M., Kurzejamski, A., Lipert, B., Wojtowicz, K., Chronowski, M., Otrocka, M., Mikula, M., Dziadziuszko, R., Brzózka, K., Rzymski, T., Mazan, A.

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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib by Dyczynski, Matheus, Yu, Yasmin, Otrocka, Magdalena, Parpal, Santiago, Braga, Tiago, Henley, Aine Brigette, Zazzi, Henric, Lerner, Mikael, Wennerberg, Krister, Viklund, Jenny, Martinsson, Jessica, Grandér, Dan, De Milito, Angelo, Pokrovskaja Tamm, Katja

“…Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this…”
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Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries by Fritzell, Kajsa, Xu, Li-Di, Otrocka, Magdalena, Andréasson, Claes, Öhman, Marie

“…Abstract Adenosine to inosine editing is common in the human transcriptome and changes of this essential activity is associated with disease. Children with…”
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A high content screening assay for discovery of antimycobacterial compounds based on primary human macrophages infected with virulent Mycobacterium tuberculosis by Kalsum, Sadaf, Otrocka, Magdalena, Andersson, Blanka, Welin, Amanda, Schön, Thomas, Jenmalm-Jensen, Annika, Lundbäck, Thomas, Lerm, Maria

“…Drug resistance in Mycobacterium tuberculosis is an emerging threat that makes the discovery of new candidate drugs a priority. In particular, drugs with high…”
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High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in sonic hedgehog-medulloblastoma by Zhou, Leilei, van Bree, Niek, Boutin, Lola, Ryu, Jinhye, Moussaud, Simon, Liu, Mingzhi, Otrocka, Magdalena, Olsson, Magnus, Falk, Anna, Wilhelm, Margareta

“…Abstract Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Current treatments have increased overall survival but…”
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A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth by Pinheiro, Tiago, Otrocka, Magdalena, Seashore-Ludlow, Brinton, Rraklli, Vilma, Holmberg, Johan, Forsberg-Nilsson, Karin, Simon, András, Kirkham, Matthew

“…Glioblastoma (GBM) is regarded as the most common malignant brain tumor but treatment options are limited. Thus, there is an unmet clinical need for compounds…”
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A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis by Tenland, Erik, Krishnan, Nitya, Rönnholm, Anna, Kalsum, Sadaf, Puthia, Manoj, Mörgelin, Matthias, Davoudi, Mina, Otrocka, Magdalena, Alaridah, Nader, Glegola-Madejska, Izabela, Sturegård, Erik, Schmidtchen, Artur, Lerm, Maria, Robertson, Brian D., Godaly, Gabriela

“…Tuberculosis has been reaffirmed as the infectious disease causing most deaths in the world. Co-infection with HIV and the increase in multi-drug resistant…”
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In Situ Target Engagement Studies in Adherent Cells by Axelsson, Hanna, Almqvist, Helena, Otrocka, Magdalena, Vallin, Michaela, Lundqvist, Sara, Hansson, Pia, Karlsson, Ulla, Lundbäck, Thomas, Seashore-Ludlow, Brinton

“…A prerequisite for successful drugs is effective binding of the desired target protein in the complex environment of a living system. Drug–target engagement…”
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Reprint of: A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth by Pinheiro, Tiago, Otrocka, Magdalena, Seashore-Ludlow, Brinton, Rraklli, Vilma, Holmberg, Johan, Forsberg-Nilsson, Karin, Simon, András, Kirkham, Matthew

“…Glioblastoma (GBM) is regarded as the most common malignant brain tumor but treatment options are limited. Thus, there is an unmet clinical need for compounds…”
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High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in SHH-medulloblastoma by Zhou, Leilei, van Bree, Niek, Boutin, Lola, Ryu, Jinhye, Moussaud, Simon, Liu, Mingzhi, Otrocka, Magdalena, Olsson, Magnus, Falk, Anna, Wilhelm, Margareta

“…Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Current treatments have increased overall survival but can lead to…”
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Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening by Engen, Karin, Rosenström, Ulrika, Axelsson, Hanna, Konda, Vivek, Dahllund, Leif, Otrocka, Magdalena, Sigmundsson, Kristmundur, Nikolaou, Alexandros, Vauquelin, Georges, Hallberg, Mathias, Jenmalm Jensen, Annika, Lundbäck, Thomas, Larhed, Mats

“…Intracerebroventricular injection of angiotensin IV, a ligand of insulin-regulated aminopeptidase (IRAP), has been shown to improve cognitive functions in…”
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Small molecule PGC-1 alpha 1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration by Pettersson-Klein, A. T., Izadi, M., Ferreira, D. M. S., Cervenka, I., Correia, J. C., Martinez-Redondo, V., Southern, M., Cameron, M., Kamenecka, T., Agudelo, L. Z., Porsmyr-Palmertz, M., Martens, Ulf, Lundgren, Bo, Otrocka, M., Jenmalm-Jensen, A., Griffin, P. R., Ruas, J. L.

“…Objective : The peroxisome proliferator-activated receptor-gamma coactivator-1 alpha 1 (PGC-1 alpha 1) regulates genes involved in energy metabolism…”
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The use of TrkA-PathHunter assay in high-throughput screening to identify compounds that affect nerve growth factor signaling by Forsell, Pontus, Almqvist, Helena, Hillertz, Per, Akerud, Tomas, Otrocka, Magdalena, Eisele, Lina, Sun, Kai, Andersson, Henrik, Trivedi, Shephali, Wollberg, Anna Ridderstad, Dekker, Niek, Rottici, Didier, Sandberg, Kristian

“…The TrkA-PathHunter cell-based assay was used in high-throughput screening (HTS) to identify compounds that inhibit nerve growth factor (NGF)/TrkA signaling…”
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The effect of methotrexate on actin and invasiveness of hepatoma Morris 5123 cells in culture by Otrocka, M, Verschueren, H, Malicka-Błaszkiewicz, M

“…Monomeric (G), total (T) and filamentous (F) actin and the state of actin polymerisation (F:G) were determined and actin filaments were visualized in hepatoma…”
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