Search Results - "Othman, Moneeb A. K."

Complex rearrangement in acute myeloid leukemia M2 with RUNX1/RUNX1T1 fusion involving chromosomes 8, 17 and 21 by Mishra, Shiba Ranjan, Rawal, Leena, Othman, Moneeb A. K, Thatai, Atul, Sarkar, Aditi, Lal, Vandana, Bhattacharya, Saurabh Kumar

“…Abstract Background The translocation t(8;21)(q22;q22) is one of the most frequent chromosomal abnormalities associated with acute myeloid leukemia (AML) sub…”
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An acquired stable variant of a dicentric dic(9;20) and complex karyotype in a Syrian childhood B-acute lymphoblastic leukemia case by Wafa, Abdulsamad, Jarjour, Rami A, Aljapawe, Abdulmunim, ALmedania, Suher, Liehr, Thomas, Melo, Joana B, Carreira, Isabel M, Othman, Moneeb A K, Al-Achkar, Walid

“…About 25 years ago, the acquired chromosome abnormality dicentric dic(9;20)(p11 ~ 13;q11) was seen described as a non-random aberration in B-cell precursor…”
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A new childhood ALL case with an extremely complex karyotype and acute spontaneous tumor lysis syndrome by Wafa, Abdulsamad, Jarjour, Rami A, Alolabi, Doaa, Liehr, Thomas, Hamdan, Othman, Melo, Joana B, Carreira, Isabel M, Othman, Moneeb A K, Al-Achkar, Walid

“…B cell precursor acute lymphoblastic leukemia (B-ALL) is the most common malignancy of childhood, with, after corresponding treatment, an overall complete…”
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Parental origin of deletions and duplications - about the necessity to check for cryptic inversions by Liehr, Thomas, Schreyer, Isolde, Kuechler, Alma, Manolakos, Emmanouil, Singer, Sylke, Dufke, Andreas, Wilhelm, Kathleen, Jančušková, Tereza, Čmejla, Radek, Othman, Moneeb A K, Al-Rikabi, Ahmed H, Mrasek, Kristin, Ziegler, Monika, Kankel, Stefanie, Kreskowski, Katharina, Weise, Anja

“…Copy number variants (CNVs) are the genetic bases for microdeletion/ microduplication syndromes (MMSs). Couples with an affected child and desire to have…”
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The current state of molecular cytogenetics in cancer diagnosis by Liehr, Thomas, Othman, Moneeb A K, Rittscher, Katharina, Alhourani, Eyad

“…Cytogenetics and molecular cytogenetics are and will continue to be indispensable tools in cancer diagnostics. Leukemia and lymphoma diagnostics are still…”
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A cryptic three-way translocation t(10;19;11)(p12.31;q13.31;q23.3) with a derivative Y-chromosome in an infant with acute myeloblastic leukemia (M5b) by Othman, Moneeb A.K., Vujić, Dragana, Zecević, Zeljko, Đurišić, Marina, Slavković, Bojana, Meyer, Britta, Liehr, Thomas

“…Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the malignant transformation of hematopoietic precursors to a pathogenic cell clone…”
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A new adult AML case with an extremely complex karyotype, remission and relapse combined with high hyperdiploidy of a normal chromosome set in secondary AML by Wafa, Abdulsamad, ALmedania, Suher, Aljapawe, Abdulmunim, Liehr, Thomas, Soulaiman, Soulaiman E, Mouna, Raja, Othman, Moneeb A K, ALachkar, Walid

“…Chromosomal abnormalities are diagnostic and prognostic key factors in acute myeloid leukemia (AML) patients, as they play a central role for risk…”
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High rates of submicroscopic aberrations in karyotypically normal acute lymphoblastic leukemia by Othman, Moneeb A K, Melo, Joana B, Carreira, Isabel M, Rincic, Martina, Glaser, Anita, Grygalewicz, Beata, Gruhn, Bernd, Wilhelm, Kathleen, Rittscher, Katharina, Meyer, Britta, Silva, Maria Luiza Macedo, de Jesus Marques Salles, Terezinha, Liehr, Thomas

“…Acute lymphoblastic leukemia (ALL) is not a single uniform disease. It consists of several subgroups with different cytogenetic and molecular genetic…”
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A unique set of complex chromosomal abnormalities in an infant with myeloid leukemia associated with Down syndrome by de Souza, Daiane Correa, de Figueiredo, Amanda Faria, Ney Garcia, Daniela R, da Costa, Elaine Sobral, Othman, Moneeb A K, Liehr, Thomas, Abdelhay, Eliana, Silva, Maria Luiza Macedo, de Souza Fernandez, Teresa

“…Children with Down syndrome (DS) have an enhanced risk of developing acute leukemia, with the most common subtype being acute megakaryoblastic leukemia (AMKL)…”
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Molecular cytogenetic studies characterizing a novel complex karyotype with an uncommon 5q22 deletion in childhood acute myeloid leukemia by de Figueiredo, Amanda Faria, Capela de Matos, Roberto Rodrigues, Othman, Moneeb A K, Liehr, Thomas, da Costa, Elaine Sobral, Land, Marcelo Geradin Poirot, Ribeiro, Raul C, Abdelhay, Eliana, Silva, Maria Luiza Macedo

“…Deletions in the long arm of chromosome 5 or loss of the whole chromosome are rare in childhood Acute Myeloid Leukemia (AML) patients. It is also unknown if…”
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Multicolor Karyotyping and Fluorescence In Situ Hybridization-Banding (MCB/mBAND) by Liehr, Thomas, Othman, Moneeb A K, Rittscher, Katharina

“…Multicolor fluorescence in situ hybridization (mFISH) approaches are routine applications in tumor as well as clinical cytogenetics nowadays. The first…”
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A Novel Cryptic Three-Way Translocation t(2;9;18)(p23.2;p21.3;q21.33) with Deletion of Tumor Suppressor Genes in 9p21.3 and 13q14 in a T-Cell Acute Lymphoblastic Leukemia by Othman, Moneeb A. K., Rincic, Martina, Melo, Joana B., Carreira, Isabel M., Alhourani, Eyad, Hunstig, Friederike, Glaser, Anita, Liehr, Thomas

“…Acute leukemia often presents with pure chromosomal resolution; thus, aberrations may not be detected by banding cytogenetics. Here, a case of 26-year-old male…”
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An Original Complex Rearrangement Involving Chromosomes 9, 11, and 14, Harboring a Complex KMT2A Gene Rearrangement in an Infant With Mixed-phenotype Acute Leukemia by Monteso, Kelly C.d.A., Othman, Moneeb A.K., Capela de Matos, Roberto R., Ney Garcia, Daniela R., da Rocha, Moisés M., de Souza, Mariana T., Albagli, Luiza F., Liehr, Thomas, Land, Marcelo G.P., Silva, Maria Luiza M., Costa, Elaine S.

“…KMT2A gene rearrangements represent the most frequent group of abnormalities in childhood leukemia (~70% of cases), with over 120 rearrangements described. The…”
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Complex karyotype with cryptic FUS gene rearrangement and deletion of NR3C1 and VPREB1 genes in childhood B-cell acute lymphoblastic leukemia: A case report by Othman, Moneeb A K, Đurišić, Marina, Samardzija, Gordana, Vujić, Dragana, Lakic, Nina, Zecevic, Zeljko, Al-Shaheri, Fawaz, Aroutiounian, Rouben, Melo, Joana B, Carreira, Isabel M, Meyer, Britta, Liehr, Thomas

“…B-cell acute lymphoblastic leukemia (B-ALL) is a hematopoietic malignancy characterized by overproduction of immature B-lymphoblasts. B-ALL is the most common…”
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Novel Cryptic Rearrangements in Adult B-Cell Precursor Acute Lymphoblastic Leukemia Involving the MLL Gene by Othman, Moneeb A. K., Grygalewicz, Beata, Pienkowska-Grela, Barbara, Rincic, Martina, Rittscher, Katharina, Melo, Joana B., Carreira, Isabel M., Meyer, Britta, Marzena, Watek, Liehr, Thomas

“…MLL (mixed-lineage-leukemia) gene rearrangements are typical for acute leukemia and are associated with an aggressive course of disease, with a worse outcome…”
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Molecular cytogenetic pilot study on pleomorphic adenomas of salivary glands by Thielker, Jovanna, Weise, Anja, Othman, Moneeb A K, Carreria, Isabel M, Melo, Joana B, Von Eggeling, Ferdinand, Guntinas-Lichius, Orlando, Ziegler, Monika, Liehr, Thomas

“…Pleomorphic adenomas (PAs) of salivary glands are the most frequent entity of solid parotid tumors. Nonetheless, their genetics is not yet well understood…”
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BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients by ALHOURANI, EYAD, OTHMAN, MONEEB A.K, MELO, JOANA B, CARREIRA, ISABEL M, GRYGALEWICZ, BEATA, VUJIĆ, DRAGANA, ZECEVIĆ, ZELJKO, JOKSIĆ, GORDANA, GLASER, ANITA, POHLE, BEATE, SCHLIE, CORDULA, HAUKE, SVEN, LIEHR, THOMAS

“…Deletions within chromosome 11q22-23, are considered among the most common chromosomal aberrations in chronic lymphocytic leukemia (CLL), and are associated…”
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Molecular characterization of KMT2A fusion partner genes in 13 cases of pediatric leukemia with complex or cryptic karyotypes by Ney Garcia, Daniela R., Souza, Mariana T., Figueiredo, Amanda F., Othman, Moneeb A. K., Rittscher, Katharina, Abdelhay, Eliana, Capela de Matos, Roberto R., Meyer, Claus, Marschalek, Rolf, Land, Marcelo G. P., Liehr, Thomas, Ribeiro, Raul C., Silva, Maria Luiza Macedo

“…In pediatric acute leukemias, reciprocal chromosomal translocations frequently cause gene fusions involving the lysine (K)‐specific methyltransferase 2A gene…”
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GAS6 Oncogene and Reverse MLLT3-KMT2A Duplications in an Infant with Acute Myeloid Leukemia and a Novel Complex Hyperdiploid Karyotype: Detailed High-Resolution Molecular Cytogenetic Studies by Capela de Matos, Roberto R, Ney Garcia, Daniela R, Cifoni, Elaine, Othman, Moneeb A K, Tavares de Souza, Mariana, Carboni, Edna K, Ferreira, Gerson M, Liehr, Thomas, Ribeiro, Raul C, M Silva, Maria Luiza

“…Pediatric acute myeloid leukemia (AML) is a highly heterogeneous disease, presenting cytogenetic and molecular abnormalities which turned out to be critical…”
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MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report by OTHMAN, MONEEB A.K, MELO, JOANA B, CARREIRA, ISABEL M, RINCIC, MARTINA, ALHOURANI, EYAD, WILHELM, KATHLEEN, GRUHN, BERND, GLASER, ANITA, LIEHR, THOMAS

“…Cytogenetic classification of acute lymphoblastic leukemia (ALL) is primarily based on numerical and structural chromosomal abnormalities. In T-cell ALL…”
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