Search Results - "Othman, Iekhsan"

Role of Inflammatory Mediators, Macrophages, and Neutrophils in Glioma Maintenance and Progression: Mechanistic Understanding and Potential Therapeutic Applications by Basheer, Abdul Samad, Abas, Faridah, Othman, Iekhsan, Naidu, Rakesh

“…Gliomas are the most common, highly malignant, and deadliest forms of brain tumors. These intra-cranial solid tumors are comprised of both cancerous and…”
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Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer by Ismail, Nor Isnida, Othman, Iekhsan, Abas, Faridah, H Lajis, Nordin, Naidu, Rakesh

“…Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality rate worldwide. It is estimated that about over than 1.1 million of…”
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HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction by Paudel, Yam Nath, Shaikh, Mohd Farooq, Chakraborti, Ayanabha, Kumari, Yatinesh, Aledo-Serrano, Ángel, Aleksovska, Katina, Alvim, Marina Koutsodontis Machado, Othman, Iekhsan

“…High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein released by glia and neurons upon inflammasome activation and activates receptor for…”
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Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting by Paudel, Yam Nath, Angelopoulou, Efthalia, Piperi, Christina, Othman, Iekhsan, Aamir, Khurram, Shaikh, Mohd Farooq

“…Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a leading cause of dementia, with accumulation of amyloid-beta (Aβ) and…”
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Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer's Disease-Like Condition in a Rat Model by Bhuvanendran, Saatheeyavaane, Kumari, Yatinesh, Othman, Iekhsan, Shaikh, Mohd Farooq

“…Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) is one of the active components (2.3%) found in Burm fruits. As determined via AChE inhibition assay,…”
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HMGB1-Mediated Neuroinflammatory Responses in Brain Injuries: Potential Mechanisms and Therapeutic Opportunities by Paudel, Yam Nath, Angelopoulou, Efthalia, Piperi, Christina, Othman, Iekhsan, Shaikh, Mohd Farooq

“…Brain injuries are devastating conditions, representing a global cause of mortality and morbidity, with no effective treatment to date. Increased evidence…”
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Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties by Siddiqui, Aisha, Shah, Zahoor, Jahan, Rao Nargis, Othman, Iekhsan, Kumari, Yatinesh

“…The resin/gum of Boswellia species belonging to the family of Burseraceae is a naturally occurring mixture of bioactive compounds, which was traditionally used…”
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Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer by Sudhesh Dev, Sareshma, Zainal Abidin, Syafiq Asnawi, Farghadani, Reyhaneh, Othman, Iekhsan, Naidu, Rakesh

“…Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like…”
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Zebrafish as a Model for Epilepsy-Induced Cognitive Dysfunction: A Pharmacological, Biochemical and Behavioral Approach by Kundap, Uday P, Kumari, Yatinesh, Othman, Iekhsan, Shaikh, Mohd Farooq

“…Epilepsy is a neuronal disorder allied with distinct neurological and behavioral alterations characterized by recurrent spontaneous epileptic seizures…”
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Anti-Cancer Mechanisms of Diarylpentanoid MS17 (1,5-Bis(2-hydroxyphenyl)-1,4-pentadiene-3-one) in Human Colon Cancer Cells: A Proteomics Approach by Hon, Kha Wai, Zainal Abidin, Syafiq Asnawi, Abas, Faridah, Othman, Iekhsan, Naidu, Rakesh

“…Diarylpentanoids are synthesized to overcome curcumin's poor bioavailability and low stability to show enhanced anti-cancer effects. Little is known about the…”
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The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer by Hon, Kha Wai, Zainal Abidin, Syafiq Asnawi, Othman, Iekhsan, Naidu, Rakesh

“…Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC…”
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Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer by Abd Wahab, Nurul Azwa, Lajis, Nordin H, Abas, Faridah, Othman, Iekhsan, Naidu, Rakesh

“…Prostate cancer (PCa) is a heterogeneous disease and ranked as the second leading cause of cancer-related deaths in males worldwide. The global burden of PCa…”
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Flavonoids as receptor tyrosine kinase inhibitors in lung cancer by Sudhesh Dev, Sareshma, Farghadani, Reyhaneh, Zainal Abidin, Syafiq Asnawi, Othman, Iekhsan, Naidu, Rakesh

“…[Display omitted] •Flavonoids exert anti-lung cancer effects via RTK modulation.•Flavonoids mainly inhibit signalling pathways like MAPK, PI3K/Akt and…”
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The Curcumin Analogue, MS13 (1,5-Bis(4-hydroxy-3- methoxyphenyl)-1,4-pentadiene-3-one), Inhibits Cell Proliferation and Induces Apoptosis in Primary and Metastatic Human Colon Cancer Cells by Ismail, Nor Isnida, Othman, Iekhsan, Abas, Faridah, H Lajis, Nordin, Naidu, Rakesh

“…The cytotoxic and apoptotic effects of turmeric (Curcuma longa) on colon cancer have been well documented but specific structural modifications of curcumin…”
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Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways by Siddiqui, Aisha, Akhtar, Sayeed, Shah, Zahoor, Othman, Iekhsan, Kumari, Yatinesh

“…It is a known fact that inflammation affects several physiological processes, including the functioning of the central nervous system. Additionally, impairment…”
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Potential economic and clinical implications of improving access to snake antivenom in five ASEAN countries: A cost-effectiveness analysis by Patikorn, Chanthawat, Ismail, Ahmad Khaldun, Zainal Abidin, Syafiq Asnawi, Othman, Iekhsan, Chaiyakunapruk, Nathorn, Taychakhoonavudh, Suthira

“…Despite domestic production of antivenoms in the Association of Southeast Asian Nations (ASEAN) countries, not all victims with snakebite envenomings indicated…”
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Anti-High Mobility Group Box-1 Monoclonal Antibody Attenuates Seizure-Induced Cognitive Decline by Suppressing Neuroinflammation in an Adult Zebrafish Model by Paudel, Yam Nath, Othman, Iekhsan, Shaikh, Mohd Farooq

“…Epilepsy is a chronic brain disease afflicting around 70 million global population and is characterized by persisting predisposition to generate epileptic…”
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Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish by Paudel, Yam Nath, Kumari, Yatinesh, Abidin, Syafiq Asnawi Zainal, Othman, Iekhsan, Shaikh, Mohd Farooq

“…Epilepsy is a devastating neurological condition exhibited by repeated spontaneous and unpredictable seizures afflicting around 70 million people globally. The…”
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Animal Venoms as Potential Source of Anticonvulsants [version 1; peer review: 3 approved] by Zainal Abidin, Syafiq Asnawi, Liew, Anthony Kin Yip, Othman, Iekhsan, Shaikh, Farooq

“…Abstract* Epilepsy affects millions of people worldwide, and there is an urgent need to develop safe and effective therapeutic agents. Animal venoms contain…”
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In Vitro neurotoxicity and myotoxicity of Malaysian Naja sumatrana and Naja kaouthia venoms: Neutralization by monovalent and Neuro Polyvalent Antivenoms from Thailand by Zukifli, Nor Asyikin, Ibrahim, Zalikha, Othman, Iekhsan, Ismail, Ahmad Khaldun, Chaisakul, Janeyuth, Hodgson, Wayne C, Ahmad Rusmili, Muhamad Rusdi

“…Naja sumatrana and Naja kaouthia are medically important elapids species found in Southeast Asia. Snake bite envenoming caused by these species may lead to…”
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