Search Results - "Otero Marcos, Ana R."

Active Site Mutations in DNA Topoisomerase I Distinguish the Cytotoxic Activities of Camptothecin and the Indolocarbazole, Rebeccamycin by Woo, Michael H., Vance, John R., Marcos, Ana R. Otero, Bailly, Christian, Bjornsti, Mary-Ann

“…DNA topoisomerase I (Top1p) catalyzes topological changes in DNA and is the cellular target of the antitumor agent camptothecin (CPT). Non-CPT drugs that…”
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A Novel Active DNA Topoisomerase I in Leishmania donovani by Villa, Héctor, Otero Marcos, Ana R., Reguera, Rosa M., Balaña-Fouce, Rafael, Garcı́a-Estrada, Carlos, Pérez-Pertejo, Yolanda, Tekwani, Babu L., Myler, Peter J., Stuart, Kenneth D., Bjornsti, Mary-Ann, Ordóñez, David

“…A common feature shared by type I DNA topoisomerases is the presence of a “serine, lysine, X,X, tyrosine” motif as conventional enzyme active site. Preliminary…”
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