Search Results - "Otero Espinar, Francisco"

Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations by Varela-Fernández, Rubén, Díaz-Tomé, Victoria, Luaces-Rodríguez, Andrea, Conde-Penedo, Andrea, García-Otero, Xurxo, Luzardo-Álvarez, Asteria, Fernández-Ferreiro, Anxo, Otero-Espinar, Francisco J

“…The treatment of the posterior-segment ocular diseases, such as age-related eye diseases (AMD) or diabetic retinopathy (DR), present a challenge for…”
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Current Situation and Challenges in Vitreous Substitutes by Mondelo‐García, Cristina, Bandín‐Vilar, Enrique, García‐Quintanilla, Laura, Castro‐Balado, Ana, del Amo, Eva M., Gil‐Martínez, María, Blanco‐Teijeiro, María José, González‐Barcia, Miguel, Zarra‐Ferro, Irene, Fernández‐Ferreiro, Anxo, Otero‐Espinar, Francisco J.

“…Vitreo‐retinal disorders constitute a significant portion of treatable ocular diseases. These pathologies often require vitreo‐retinal surgery and, as a…”
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3D printed tacrolimus suppositories for the treatment of ulcerative colitis by Seoane-Viaño, Iria, Ong, Jun Jie, Luzardo-Álvarez, Asteria, González-Barcia, Miguel, Basit, Abdul W., Otero-Espinar, Francisco J., Goyanes, Alvaro

“…Ulcerative colitis is a global health problem, affecting millions of individuals worldwide. As an inflammatory condition localised in the large intestine,…”
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Cyclodextrin based rotaxanes, polyrotaxanes and polypseudorotaxanes and their biomedical applications by García-Río, Luis, Otero-Espinar, Francisco J, Luzardo-Alvarez, Asteria, Blanco-Méndez, José

“…For years, great efforts have been made by scientists to construct various novel interlocked supramolecular systems. A wide range of pseudorotaxanes and…”
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Plasma Proteomic Analysis in Morquio A Disease by Álvarez, José V, Bravo, Susana B, Chantada-Vázquez, María Pilar, Barbosa-Gouveia, Sofía, Colón, Cristóbal, López-Suarez, Olalla, Tomatsu, Shunji, Otero-Espinar, Francisco J, Couce, María L

“…Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal disease caused by mutations in the gene encoding the enzyme -acetylgalactosamine-6-sulfate sulfatase…”
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Enhancement in corneal permeability of riboflavin using cyclodextrin derivates complexes as a previous step to transepithelial cross-linking by Conde Penedo, Andrea, Díaz Tomé, Victoria, Fernández Ferreiro, Anxo, González Barcia, Miguel, Otero Espinar, Francisco J.

“…[Display omitted] Corneal cross-linking has been described as an effective treatment to slow the progression of keratoconus. The standard protocol entails…”
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Efficacy and safety of a new medicated nail hydrolacquer in the treatment of adults with toenail onychomycosis: A randomised clinical trial by Zalacain‐Vicuña, Antonio J., Nieto, Carlos, Picas, Jordi, Martínez, Helena, Bermejo, Rafael, Corrales, Adrián, Campos, Francisco Fernández, Igea, Soledad Anguiano, Otero‐Espinar, Francisco Javier, Briones, Vicente García‐Patos

“…Background A new water‐soluble formulation with ciclopirox has shown a higher penetration than other ciclopirox nail lacquers currently marketed, thus…”
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PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor by Fernandes, Carlos, Martins, Cláudia, Fonseca, André, Nunes, Rute, Matos, Maria João, Silva, Renata, Garrido, Jorge, Sarmento, Bruno, Remião, Fernando, Otero-Espinar, Francisco J, Uriarte, Eugenio, Borges, Fernanda

“…Despite research efforts to discover new drugs for Parkinson treatment, the majority of candidates fail in preclinical and clinical trials due to inadequate…”
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Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers by Cutrín-Gómez, Elena, Anguiano-Igea, Soledad, Delgado-Charro, M Begoña, Gómez-Amoza, José Luis, Otero-Espinar, Francisco J

“…Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low permeability of drugs in the nail plaque precludes the efficacy of local…”
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Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration by García-Quintanilla, Laura, Luaces-Rodríguez, Andrea, Gil-Martínez, María, Mondelo-García, Cristina, Maroñas, Olalla, Mangas-Sanjuan, Víctor, González-Barcia, Miguel, Zarra-Ferro, Irene, Aguiar, Pablo, Otero-Espinar, Francisco J, Fernández-Ferreiro, Anxo

“…Intravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has become the standard treatment for Age-Related Macular…”
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Morquio A Syndrome: Identification of Differential Patterns of Molecular Pathway Interactions in Bone Lesions by Álvarez, J Victor, Bravo, Susana B, Chantada-Vázquez, María Pilar, Pena, Carmen, Colón, Cristóbal, Tomatsu, Shunji, Otero-Espinar, Francisco J, Couce, María L

“…Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome) is a rare autosomal recessive lysosomal storage disease (LSD) caused by deficiency of a hydrolase…”
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Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers by Cutrín-Gómez, Elena, Conde-Penedo, Andrea, Anguiano-Igea, Soledad, Gómez-Amoza, José Luis, Otero-Espinar, Francisco J

“…Cyclodextrin/poloxamer-soluble polypseudorotaxane-based nail lacquers have demonstrated significant capacity for promoting the permeation of drugs into the…”
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Clinical Effectiveness, Safety, and Compliance of Two Compounded Formulations of Tacrolimus Eye Drops: An Open-Label, Sequential Prospective Study by Puente-Iglesias, María, Cuartero-Martínez, Andrea, Touriño-Peralba, Rosario, Rodríguez-Ares, María Teresa, Giráldez, María Jesús, Yebra-Pimentel, Eva, García-Quintanilla, Laura, García-Otero, Xurxo, González-Barcia, Miguel, Zarra-Ferro, Irene, Otero-Espinar, Francisco J, Fernández-Ferreiro, Anxo, Castro-Balado, Ana

“…Ophthalmic tacrolimus compounded formulations are usually made from the commercial intravenous presentation, which contains ethanol as a solubilizer due to the…”
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Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer by Cutrín-Gómez, Elena, Anguiano-Igea, Soledad, Delgado-Charro, M Begoña, Gómez-Amoza, José Luis, Otero-Espinar, Francisco J

“…Aqueous-based nail lacquers have shown potential in promoting the diffusion of drugs into the nail. In our laboratory, we have recently developed a transungual…”
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Fighting type 2 diabetes: Formulation strategies for peptide-based therapeutics by Bendicho-Lavilla, Carlos, Seoane-Viaño, Iria, Otero-Espinar, Francisco J., Luzardo-Álvarez, Asteria

“…Diabetes mellitus is a major health problem with increasing prevalence at a global level. The discovery of insulin in the early 1900s represented a major…”
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Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy by Moles-Aranda, Cristina, Calpena-Campmany, Ana C, Halbaut-Bellowa, Lyda, Díaz-Tomé, Victoria, Otero-Espinar, Francisco J, Morales-Molina, José A, Clares-Naveros, Beatriz

“…Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are two techniques used in the resection of gastrointestinal mucosal polyps. The…”
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The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment by Seoane-Viaño, Iria, Seoane-Gigirey, Mariola, Bendicho-Lavilla, Carlos, Gigirey, Luz M, Otero-Espinar, Francisco J, Seoane-Trigo, Santiago

“…Despite the high success rates of dental implants, peri-implantitis is currently the most common complication in dental implantology. Peri-implantitis has an…”
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Characterization of New Proteomic Biomarker Candidates in Mucopolysaccharidosis Type IVA by Álvarez, Víctor J, Bravo, Susana B, Chantada-Vazquez, Maria Pilar, Colón, Cristóbal, De Castro, María J, Morales, Montserrat, Vitoria, Isidro, Tomatsu, Shunji, Otero-Espinar, Francisco J, Couce, María L

“…Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the -acetylgalactosamine-6-sulfatase ( ) gene. Skeletal…”
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Mucoadhesive Tablets for Controlled Release of Acyclovir by Ruiz-Caro, Roberto, Gago-Guillan, Manuel, Otero-Espinar, Francisco Javier, Veiga, María Dolores

“…Mucoadhesive chitosan (CS) and/or hydroxypropyl-methylcellulose (HPMC) tablets for gastric drug delivery of acyclovir (ACV) have been developed in order to…”
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3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of Inflammatory Bowel Disease by Seoane-Viaño, Iria, Gómez-Lado, Noemí, Lázare-Iglesias, Héctor, García-Otero, Xurxo, Antúnez-López, José Ramón, Ruibal, Álvaro, Varela-Correa, Juan Jesús, Aguiar, Pablo, Basit, Abdul W, Otero-Espinar, Francisco J, González-Barcia, Miguel, Goyanes, Alvaro, Luzardo-Álvarez, Asteria, Fernández-Ferreiro, Anxo

“…The aim of this study was to fabricate novel self-supporting tacrolimus suppositories using semisolid extrusion 3-dimensional printing (3DP) and to investigate…”
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