Search Results - "Otero, José M."

A New Solid-State Proton Conductor: The Salt Hydrate Based on Imidazolium and 12-Tungstophosphate by Martinelli, Anna, Otero-Mato, José M, Garaga, Mounesha N, Elamin, Khalid, Rahman, Seikh Mohammad Habibur, Zwanziger, Josef W, Werner-Zwanziger, Ulrike, Varela, Luis M

“…We report the structure and charge transport properties of a novel solid-state proton conductor obtained by acid–base chemistry via proton transfer from…”
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Structure of the bacteriophage T4 long tail fiber receptor-binding tip by Bartual, Sergio G., Otero, José M., Garcia-Doval, Carmela, Llamas-Saiz, Antonio L., Kahn, Richard, Fox, Gavin C., van Raaij, Mark J., King, Jonathan A.

“…Bacteriophages are the most numerous organisms in the biosphere. In spite of their biological significance and the spectrum of potential applications, little…”
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Implementation of QbD for the development of a vaccine candidate by Haas, Jennifer, Franklin, Andrew, Houser, Matthew, Maraldo, David, Mikola, Mark, Ortiz, Roberto, Sullivan, Elizabeth, Otero, José M

“…Abstract This case study provides an example of how Quality by Design (QbD) principles were applied to accelerate process development to manufacture a vaccine…”
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Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct by González-Bello, Concepción, Tizón, Lorena, Lence, Emilio, Otero, José M, van Raaij, Mark J, Martinez-Guitian, Marta, Beceiro, Alejandro, Thompson, Paul, Hawkins, Alastair R

“…The first example of an ammonium derivative that causes a specific modification of the active site of type I dehydroquinase (DHQ1), a dehydratase enzyme that…”
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Structure of the Receptor-Binding Carboxy-Terminal Domain of the Bacteriophage T5 L-Shaped Tail Fibre with and without Its Intra-Molecular Chaperone by Garcia-Doval, Carmela, Castón, José R, Luque, Daniel, Granell, Meritxell, Otero, José M, Llamas-Saiz, Antonio L, Renouard, Madalena, Boulanger, Pascale, van Raaij, Mark J

“…Bacteriophage T5, a Siphovirus belonging to the order Caudovirales, has a flexible, three-fold symmetric tail, to which three L-shaped fibres are attached…”
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Inhibiting and Reversing Amyloid-β Peptide (1-40) Fibril Formation with Gramicidin S and Engineered Analogues by Luo, Jinghui, Otero, José M., Yu, Chien-Hung, Wärmländer, Sebastian K. T. S., Gräslund, Astrid, Overhand, Mark, Abrahams, Jan Pieter

“…In Alzheimer’s disease, amyloid‐β (Aβ) peptides aggregate into extracellular fibrillar deposits. Although these deposits may not be the prime cause of the…”
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6-Deoxyhexoses from l-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology by Liu, Zilei, Yoshihara, Akihide, Kelly, Ciarán, Heap, John T., Marqvorsen, Mikkel H. S., Jenkinson, Sarah F., Wormald, Mark R., Otero, José M., Estévez, Amalia, Kato, Atsushi, Fleet, George W. J., Estévez, Ramón J., Izumori, Ken

“…In the search for alternative non‐metabolizable inducers in the l‐rhamnose promoter system, the synthesis of fifteen 6‐deoxyhexoses from l‐rhamnose…”
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A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors by Tizón, Lorena, Otero, José M, Prazeres, Verónica F. V, Llamas-Saiz, Antonio L, Fox, Gavin C, van Raaij, Mark J, Lamb, Heather, Hawkins, Alastair R, Ainsa, José A, Castedo, Luis, González-Bello, Concepción

“…The synthesis of high-affinity reversible competitive inhibitors of Mycobacterium tuberculosis type II dehydroquinase, an essential enzyme in Mycobacterium…”
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An Adamantyl Amino Acid Containing Gramicidin S Analogue with Broad Spectrum Antibacterial Activity and Reduced Hemolytic Activity by Kapoerchan, Varsha V., Knijnenburg, Annemiek D., Niamat, Miquel, Spalburg, Emile, de Neeling, Albert J., Nibbering, Peter H., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…The cyclic cationic antimicrobial peptide gramicidin S (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis)…”
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Exploring the Conformational and Biological Versatility of β-Turn-Modified Gramicidin S by Using Sugar Amino Acid Homologues that Vary in Ring Size by Knijnenburg, Annemiek D., Tuin, Adriaan W., Spalburg, Emile, de Neeling, Albert J., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…Monobenzylated sugar amino acids (SAAs) that differ in ether ring size (containing an oxetane, furanoid, and pyranoid ring) were synthesized and incorporated…”
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On a Possible Neutral Charge State for the Catalytic Dyad in β-Secretase When Bound to Hydroxyethylene Transition State Analogue Inhibitors by Sussman, Fredy, Otero, José M, Villaverde, M. Carmen, Castro, Marian, Domínguez, José L, González-Louro, Lucía, Estévez, Ramón J, Estévez, J. Carlos

“…β-Secretase is one of the aspartic proteases involved in the formation of amyloid plaques in Alzheimer’s disease patients. Our previous results using a…”
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Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)‑2-Benzyl-3-dehydroquinic Acids by Lence, Emilio, Tizón, Lorena, Otero, José M, Peón, Antonio, Prazeres, Verónica F. V, Llamas-Saiz, Antonio L, Fox, Gavin C, van Raaij, Mark J, Lamb, Heather, Hawkins, Alastair R, González-Bello, Concepción

“…The structural changes caused by the substitution of the aromatic moiety in (2S)-2-benzyl-3-dehydroquinic acids and its epimers in C2 by electron-withdrawing…”
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‘Inverted’ analogs of the antibiotic gramicidin S with an improved biological profile by Kapoerchan, Varsha V., Knijnenburg, Annemiek D., Keizer, Peter, Spalburg, Emile, de Neeling, Albert J., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…A series of gramicidin S derivatives 4–15 are presented that have four ornithine residues as polar protonated side chains and two central hydrophobic amino…”
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Design, Synthesis, and Structural Analysis of Turn Modified cyclo-(αβ3αβ2α)2 Peptide Derivatives toward Crystalline Hexagon-Shaped Cationic Nanochannel Assemblies by Otero, José M, van der Knaap, Matthijs, Llamas-Saiz, Antonio L, van Raaij, Mark J, Amorín, Manuel, Granja, Juan R, Filippov, Dmitri V, van der Marel, Gijsbert A, Overkleeft, Herman S, Overhand, Mark

“…Intrigued by the not fully extended hairpin monomeric structure of the previously reported cyclo-(αβ3αβ2α)2 peptide 2, as well as its nanochannel…”
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Gramicidin S Derivatives Containing cis- and trans-Morpholine Amino Acids (MAAs) as Turn Mimetics by Kapoerchan, Varsha V., Spalburg, Emile, de Neeling, Albert. J., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Ferraces-Casais, Patricia, Llamas-Saiz, Antonio L., van Raaij, Mark J., van Doorn, Joop, van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…The cyclic decapeptide gramicidin S (GS) was used as a model for the evaluation of four turn mimetics. For this purpose, one of the D‐Phe‐Pro two‐residue turn…”
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Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives by Knijnenburg, Annemiek D., Kapoerchan, Varsha V., Grotenbreg, Gijsbert M., Spalburg, Emile, de Neeling, Albert J., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., Ravensbergen, Bep, Nibbering, Peter H., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…In this paper, we describe the crystal structure of previously reported ring-extended gramicidin S (GS) derivative 2 (GS14K4), containing a d-amino acid…”
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Bisphosphine-Functionalized Cyclic Decapeptides Based on the Natural Product Gramicidin S: A Potential Scaffold for Transition-Metal Coordination by Burck, Sebastian, van Assema, Sander G. A., Lastdrager, Bas, Slootweg, J. Chris, Ehlers, Andreas W., Otero, José M., Dacunha-Marinho, Bruno, Llamas-Saiz, Antonio L., Overhand, Mark, van Raaij, Mark J., Lammertsma, Koop

“…The natural product Gramicidin S is a promising scaffold for novel oligopeptide‐based bisphosphine ligands, combining the advantageous rigid chiral backbone…”
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Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction by Kryshtafovych, Andriy, Moult, John, Bartual, Sergio G., Bazan, J. Fernando, Berman, Helen, Casteel, Darren E., Christodoulou, Evangelos, Everett, John K., Hausmann, Jens, Heidebrecht, Tatjana, Hills, Tanya, Hui, Raymond, Hunt, John F., Seetharaman, Jayaraman, Joachimiak, Andrzej, Kennedy, Michael A., Kim, Choel, Lingel, Andreas, Michalska, Karolina, Montelione, Gaetano T., Otero, José M., Perrakis, Anastassis, Pizarro, Juan C., van Raaij, Mark J., Ramelot, Theresa A., Rousseau, Francois, Tong, Liang, Wernimont, Amy K., Young, Jasmine, Schwede, Torsten

“…One goal of the CASP community wide experiment on the critical assessment of techniques for protein structure prediction is to identify the current state of…”
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Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified d-phenylalanine residues by van der Knaap, Matthijs, Engels, Eefje, Busscher, Henk J., Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., Mars-Groenendijk, Roos H., Noort, Daan, van der Marel, Gijsbert A., Overkleeft, Herman S., Overhand, Mark

“…The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified d-phenylalanine residue, their antibacterial properties…”
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Understanding the Key Factors that Control the Inhibition of Type II Dehydroquinase by (2R)-2-Benzyl-3-dehydroquinic Acids by Peón, Antonio, Otero, José M., Tizón, Lorena, Prazeres, Verónica F. V., Llamas-Saiz, Antonio L., Fox, Gavin C., van Raaij, Mark J., Lamb, Heather, Hawkins, Alastair R., Gago, Federico, Castedo, Luis, González-Bello, Concepción

“…The binding mode of several substrate analogues, (2R)‐2‐benzyl‐3‐dehydroquinic acids 4, which are potent reversible competitive inhibitors of type II…”
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