Search Results - "Otaki, Shizuo"
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Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1
Published in Journal of molecular biology (04-05-2007)“…Removal of the fucose residue from the oligosaccharides attached to Asn297 of human immunoglobulin G1 (IgG1) results in a significant enhancement of…”
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UCS1025A and B, New Antitumor Antibiotics from the Fungus Acremonium Species
Published in Organic letters (12-12-2002)“…UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The…”
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Discovery and Structure−Activity Relationships of Novel Piperidine Inhibitors of Farnesyltransferase
Published in Journal of medicinal chemistry (05-06-2003)“…A novel piperidine series of farnesyltransferase (FTase) inhibitors is described. Systematic medicinal chemistry studies starting with the lead compound,…”
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Unique binding pocket for KW-4679 in the histamine H1 receptor
Published in European journal of pharmacology (12-03-1998)“…The histamine H1 receptor has an aspartate (Asp) residue in transmembrane helix 3 (TM3), which is well-conserved among biogenic amine receptors. The Asp…”
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Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives
Published in Journal of medicinal chemistry (01-05-1992)“…A new series of 11-substituted 6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid derivatives was synthesized and demonstrated to be orally active antiallergic…”
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A Facile Synthesis of the Substituted Tetrahydronapthalenes by the Banzo-Peterson Reaction
Published in Heterocycles (1985)Get full text
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The total synthesis of (+)-sikkimotoxin via the Benzo-Peterson reaction
Published in Heterocycles (1987)Get full text
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Unique binding pocket for KW-4679 in the histamine H 1 receptor
Published in European journal of pharmacology (12-03-1998)“…The histamine H 1 receptor has an aspartate (Asp) residue in transmembrane helix 3 (TM3), which is well-conserved among biogenic amine receptors. The Asp…”
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