Search Results - "Ota, Yasunori"

Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial by Todo, Tomoki, Ito, Hirotaka, Ino, Yasushi, Ohtsu, Hiroshi, Ota, Yasunori, Shibahara, Junji, Tanaka, Minoru

“…This investigator-initiated, phase 2, single-arm trial primarily assessed the efficacy of G47∆, a triple-mutated, third-generation oncolytic herpes simplex…”
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Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation by Taya, Yuki, Ota, Yasunori, Wilkinson, Adam C., Kanazawa, Ayano, Watarai, Hiroshi, Kasai, Masataka, Nakauchi, Hiromitsu, Yamazaki, Satoshi

“…A specialized bone marrow microenvironment (niche) regulates hematopoietic stem cell (HSC) self-renewal and commitment. For successful donor-HSC engraftment,…”
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Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation by Nagase, Reina, Inoue, Daichi, Pastore, Alessandro, Fujino, Takeshi, Hou, Hsin-An, Yamasaki, Norimasa, Goyama, Susumu, Saika, Makoto, Kanai, Akinori, Sera, Yasuyuki, Horikawa, Sayuri, Ota, Yasunori, Asada, Shuhei, Hayashi, Yasutaka, Kawabata, Kimihito Cojin, Takeda, Reina, Tien, Hwei-Fang, Honda, Hiroaki, Abdel-Wahab, Omar, Kitamura, Toshio

“…( ) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic…”
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Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation by Maeda, Daichi, Akiyama, Yoshiyuki, Morikawa, Teppei, Kunita, Akiko, Ota, Yasunori, Katoh, Hiroto, Niimi, Aya, Nomiya, Akira, Ishikawa, Shumpei, Goto, Akiteru, Igawa, Yasuhiko, Fukayama, Masashi, Homma, Yukio

“…Interstitial cystitis (IC) is a chronic bladder disease with urinary frequency, bladder discomfort or bladder pain of unknown etiology. Based on cystoscopic…”
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CHIP‐associated mutant ASXL1 in blood cells promotes solid tumor progression by Liu, Xiaoxiao, Sato, Naru, Shimosato, Yuko, Wang, Teh‐Wei, Denda, Tamami, Chang, Yu‐Hsuan, Yabushita, Tomohiro, Fujino, Takeshi, Asada, Shuhei, Tanaka, Yosuke, Fukuyama, Tomofusa, Enomoto, Yutaka, Ota, Yasunori, Sakamoto, Takeharu, Kitamura, Toshio, Goyama, Susumu

“…Clonal hematopoiesis of indeterminate potential (CHIP) is an age‐associated phenomenon characterized by clonal expansion of blood cells harboring somatic…”
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Diffuse Large B-cell Lymphoma with Adrenal Involvement Presenting as Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorders: Sustained Remission with Methotrexate Termination Alone in Two Cases by Yasuda, Hajime, Ando, Jun, Yoshida, Sayako, Ota, Yasunori, Komatsu, Norio, Ando, Miki

“…Methotrexate-associated lymphoproliferative disorders (MTX-LPDs) with diffuse large B-cell lymphoma (DLBCL) pathology present with high rates of spontaneous…”
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Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice by Kon, Ayana, Yamazaki, Satoshi, Nannya, Yasuhito, Kataoka, Keisuke, Ota, Yasunori, Nakagawa, Masahiro Marshall, Yoshida, Kenichi, Shiozawa, Yusuke, Morita, Maiko, Yoshizato, Tetsuichi, Sanada, Masashi, Nakayama, Manabu, Koseki, Haruhiko, Nakauchi, Hiromitsu, Ogawa, Seishi

“…Splicing factor mutations are characteristic of myelodysplastic syndromes (MDS) and related myeloid neoplasms and implicated in their pathogenesis, but their…”
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Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA‐A24‐positive pancreatic adenocarcinoma by Shima, Hiroaki, Tsurita, Giichiro, Wada, Satoshi, Hirohashi, Yoshihiko, Yasui, Hiroshi, Hayashi, Hiroshi, Miyakoshi, Takashi, Watanabe, Kazue, Murai, Aiko, Asanuma, Hiroko, Tokita, Serina, Kubo, Terufumi, Nakatsugawa, Munehide, Kanaseki, Takayuki, Tsukahara, Tomohide, Nakae, Yutaka, Sugita, Osamu, Ito, Yoichi M., Ota, Yasunori, Kimura, Yasutoshi, Kutomi, Goro, Hirata, Koichi, Mizuguchi, Toru, Imai, Kohzoh, Takemasa, Ichiro, Sato, Noriyuki, Torigoe, Toshihiko

“…The prognosis of advanced pancreatic adenocarcinoma is still extremely poor. This study sought to determine the efficacy of, and immunological response to,…”
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Ultrasonographic evaluation of intravenous lobular capillary hemangioma in the cephalic vein by Yabunaka, Koichi, Oshima, Haruka, Ota, Yasunori, Matsuzaki, Masayo

“…A 60-year-old man presented with focal swelling on the dorsal surface of the left wrist. The sonographic exam revealed the presence of a smoothly rounded…”
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Case report: Irinotecan-induced interstitial lung disease in an advanced colorectal cancer patient resurfacing decades after allogeneic bone marrow transplantation for aplastic anemia; a case report and narrative review of literature by Baba, Keisuke, Matsubara, Yasuo, Hirata, Yoshihiro, Ota, Yasunori, Takahashi, Satoshi, Boku, Narikazu

“…Two mechanisms of drug-induced interstitial lung disease (DILD) have been reported: 1) direct injury of lung epithelial cells and/or endothelial cells in lung…”
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Pharmacological targeting of plasmin prevents lethality in a murine model of macrophage activation syndrome by Shimazu, Hiroshi, Munakata, Shinya, Tashiro, Yoshihiko, Salama, Yousef, Dhahri, Douaa, Eiamboonsert, Salita, Ota, Yasunori, Onoda, Haruo, Tsuda, Yuko, Okada, Yoshio, Nakauchi, Hiromitsu, Heissig, Beate, Hattori, Koichi

“…Macrophage activation syndrome (MAS) is a life-threatening disorder characterized by a cytokine storm and multiorgan dysfunction due to excessive immune…”
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Identification of odontogenic ameloblast associated as a novel target gene of the Wnt/β‐catenin signaling pathway by Yamaguchi, Kiyoshi, Horie, Chiaki, Takane, Kiyoko, Ikenoue, Tsuneo, Nakagawa, Saya, Isobe, Yumiko, Ota, Yasunori, Ushiku, Tetsuo, Tanaka, Mariko, Fujishiro, Jun, Hoshino, Noriko, Arisue, Atsuhiro, Nishizuka, Satoshi, Aikou, Susumu, Shida, Dai, Furukawa, Yoichi

“…The Wnt/β‐catenin signaling pathway plays a key role in development and carcinogenesis. Although some target genes of this signaling have been identified in…”
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Safe Use of Nivolumab in a Patient with Epipharyngeal Carcinoma and Preexisting Ulcerative Colitis: A Histologically Proven Case Report by Hijikata, Yasuki, Matsubara, Yasuo, Ota, Yasunori, Lim, Lay Ahyoung, Tani, Kenzaburo, Hirata, Yoshihiro, Yotsuyanagi, Hiroshi

“…Nivolumab, an antibody against human programmed cell death 1 (PD-1), enhances pre-existing immune responses and has antitumor activity. However, it may also…”
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An interspecies barrier to tetraploid complementation and chimera formation by Yamaguchi, Tomoyuki, Sato, Hideyuki, Kobayashi, Toshihiro, Kato-itoh, Megumi, Goto, Teppei, Hara, Hiromasa, Mizuno, Naoaki, Yanagida, Ayaka, Umino, Ayumi, Hamanaka, Sanae, Suchy, Fabian, Masaki, Hideki, Ota, Yasunori, Hirabayashi, Masumi, Nakauchi, Hiromitsu

“…To study development of the conceptus in xenogeneic environments, we assessed interspecies chimera formation as well as tetraploid complementation between…”
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Gastrointestinal lesion in adult-onset Langerhans cell histiocytosis by Matsubara, Yasuo, Kobayashi, Masayuki, Hijikata, Yasuki, Ota, Yasunori, Hirata, Yoshihiro, Lim, Lay Ahyoung, Yotsuyanagi, Hiroshi, Tojo, Arinobu

“…Background Langerhans cell histiocytosis (LCH) is a rare disease primarily occurring in children, and commonly involves the bone and skin; gastrointestinal…”
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Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma by Hirano, Mitsuhito, Imai, Yoichi, Kaito, Yuta, Murayama, Takahiko, Sato, Kota, Ishida, Tadao, Yamamoto, Junichi, Ito, Takumi, Futami, Muneyoshi, Ri, Masaki, Yasui, Hiroshi, Denda, Tamami, Tanaka, Yukihisa, Ota, Yasunori, Nojima, Masanori, Kamikubo, Yasuhiko, Gotoh, Noriko, Iida, Shinsuke, Handa, Hiroshi, Tojo, Arinobu

“…Multiple myeloma (MM) is an incurable disease. The acquisition of resistance to drugs, including immunomodulatory drugs (IMiDs), has a negative effect on its…”
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Gain‐of‐function mutations and copy number increases of Notch2 in diffuse large B‐cell lymphoma by Lee, Suk‐young, Kumano, Keiki, Nakazaki, Kumi, Sanada, Masashi, Matsumoto, Akihiko, Yamamoto, Go, Nannya, Yasuhito, Suzuki, Ritsuro, Ota, Satoshi, Ota, Yasunori, Izutsu, Koji, Sakata‐Yanagimoto, Mamiko, Hangaishi, Akira, Yagita, Hideo, Fukayama, Masashi, Seto, Masao, Kurokawa, Mineo, Ogawa, Seishi, Chiba, Shigeru

“…Signaling through the Notch1 receptor has a pivotal role in early thymocyte development. Gain of Notch1 function results in the development of T‐cell acute…”
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Primary Central Nervous System Post-transplant Lymphoproliferative Disorder Diagnosed by Peripheral Facial Nerve Palsy by Imafuku, Aya, Tanaka, Kiho, Marui, Yuji, Ubara, Yoshifumi, Takaichi, Kenmei, Tomikawa, Shinji, Ota, Yasunori, Fujii, Takeshi, Ishii, Yasuo

“…Although primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) causes various symptoms depending on the tumor region, there…”
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MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis by Hayashi, Yasutaka, Kawabata, Kimihito C, Tanaka, Yosuke, Uehara, Yasufumi, Mabuchi, Yo, Murakami, Koichi, Nishiyama, Akira, Kiryu, Shigeru, Yoshioka, Yusuke, Ota, Yasunori, Sugiyama, Tatsuki, Mikami, Keiko, Tamura, Moe, Fukushima, Tsuyoshi, Asada, Shuhei, Takeda, Reina, Kunisaki, Yuya, Fukuyama, Tomofusa, Yokoyama, Kazuaki, Uchida, Tomoyuki, Hagihara, Masao, Ohno, Nobuhiro, Usuki, Kensuke, Tojo, Arinobu, Katayama, Yoshio, Goyama, Susumu, Arai, Fumio, Tamura, Tomohiko, Nagasawa, Takashi, Ochiya, Takahiro, Inoue, Daichi, Kitamura, Toshio

“…Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells (HSCs), characterized by ineffective hematopoiesis and frequent progression to…”
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Formation of a Colo-colonic Fistula Communicating with the Transverse Colon in Cecal Cancer: A Case Report by Onoyama, Haruna, Kojima, Shigehiro, Ahiko, Yuka, Sakuyama, Naoki, Monma, Satoko, Aikou, Susumu, Ota, Yasunori, Shida, Dai

“…Although colorectal cancer frequently invades adjacent organs, colon-to-colon invasion is rarely observed, and colo-colonic fistula formation due to colorectal…”
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