Search Results - "Oszmiana, Anna"
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A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models
Published in Biomaterials (01-12-2019)“…Epithelial cells experience constant mechanical forces, including fluid shear stress (FSS) on their apical surface. These forces alter both structure and…”
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2
Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow
Published in The Journal of clinical investigation (01-06-2020)“…The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The…”
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3
The Size of Activating and Inhibitory Killer Ig-like Receptor Nanoclusters Is Controlled by the Transmembrane Sequence and Affects Signaling
Published in Cell reports (Cambridge) (31-05-2016)“…Super-resolution microscopy has revealed that immune cell receptors are organized in nanoscale clusters at cell surfaces and immune synapses. However,…”
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NsaRS is a cell-envelope-stress-sensing two-component system of Staphylococcus aureus
Published in Microbiology (Society for General Microbiology) (01-08-2011)“…Staphylococcus aureus possesses 16 two-component systems (TCSs), two of which (GraRS and NsaRS) belong to the intramembrane-sensing histidine kinase (IM-HK)…”
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5
A "prime-pull" vaccine strategy has a modest effect on local and systemic antibody responses to HIV gp140 in mice
Published in PloS one (19-11-2013)“…One potential strategy for the prevention of HIV infection is to induce virus specific mucosal antibody that can act as an immune barrier to prevent…”
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Journal Article -
6
Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye
Published in PLoS pathogens (01-05-2018)“…Recent outbreaks of Ebola and Zika have highlighted the possibility that viruses may cause enduring infections in tissues like the eye, including the neural…”
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7
When form meets function: the cells and signals that shape the lymphatic vasculature during development
Published in Development (Cambridge) (01-06-2021)“…ABSTRACT The lymphatic vasculature is an integral component of the cardiovascular system. It is essential to maintain tissue fluid homeostasis, direct immune…”
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8
A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature
Published in Nature (London) (09-02-2023)“…Transcriptional enhancer elements are responsible for orchestrating the temporal and spatial control over gene expression that is crucial for programming cell…”
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An actin cytoskeletal barrier inhibits lytic granule release from natural killer cells in patients with Chediak-Higashi syndrome
Published in Journal of allergy and clinical immunology (01-09-2018)“…Chediak-Higashi syndrome (CHS) is a rare disorder caused by biallelic mutations in the lysosomal trafficking regulator gene (LYST), resulting in formation of…”
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10
Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity
Published in Blood (06-06-2013)“…Rituximab, which binds CD20 on B cells, is one of the best-characterized antibodies used in the treatment of B-cell malignancies and autoimmune diseases…”
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11
The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse
Published in Immunological reviews (01-11-2013)“…Summary Natural killer (NK) cells discriminate between healthy and unhealthy target cells through a balance of activating and inhibitory signals at direct…”
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Journal Article -
12
Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow
Published in The Journal of clinical investigation (01-06-2020)“…The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The…”
Get full text
Journal Article -
13
Superresolution microscopy reveals nanometer-scale reorganization of inhibitory natural killer cell receptors upon activation of NKG2D
Published in Science signaling (23-07-2013)“…Natural killer (NK) cell responses are regulated by a dynamic equilibrium between activating and inhibitory receptor signals at the immune synapse (or…”
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Journal Article -
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Nanometre-Scale Organization of the Natural Killer Cell Receptors KIR2DL1 and KIR2DS1 and Its Implications for Signalling
Published 01-01-2016“…Human Natural Killer (NK) cells are regulated by a variety of germ-line encoded activating and inhibitory receptors. Broadly, activating receptors detect…”
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Dissertation -
15
A "Prime-Pull" Vaccine Strategy Has a Modest Effect on Local and Systemic Antibody Responses to HIV gp140 in Mice: e80559
Published in PloS one (01-11-2013)“…One potential strategy for the prevention of HIV infection is to induce virus specific mucosal antibody that can act as an immune barrier to prevent…”
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Journal Article