Search Results - "Ostrow, J Donald"

Bilirubin chemistry and metabolism; harmful and protective aspects by Vítek, Libor, Ostrow, J Donald

“…Unconjugated bilirubin (UCB), the principal mammalian bile pigment, is the end product of heme catabolism. Both belong to the superfamily of tetrapyrrolic…”
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Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat by Gazzin, Silvia, Berengeno, Andrea Lorena, Strazielle, Nathalie, Fazzari, Francesco, Raseni, Alan, Ostrow, J Donald, Wennberg, Richard, Ghersi-Egea, Jean-François, Tiribelli, Claudio

“…Accumulation of unconjugated bilirubin (UCB) in the brain causes bilirubin encephalopathy. Pgp (ABCb1) and Mrp1 (ABCc1), highly expressed in the blood-brain…”
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Unbound (Free) Bilirubin: Improving the Paradigm for Evaluating Neonatal Jaundice by Ahlfors, Charles E, Wennberg, Richard P, Ostrow, J. Donald, Tiribelli, Claudio

“…The serum or plasma total bilirubin concentration (B(T)) has long been the standard clinical laboratory test for evaluating neonatal jaundice, despite studies…”
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Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces by Gazzin, Silvia, Strazielle, Nathalie, Schmitt, Charlotte, Fevre-Montange, Michelle, Ostrow, J. Donald, Tiribelli, Claudio, Ghersi-Egea, Jean-François

“…Cerebral homeostasis results from the presence of the protective blood‐brain and blood‐cerebrospinal fluid barriers located respectively at the brain capillary…”
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Kinetics and Specificity of Feline Leukemia Virus Subgroup C Receptor (FLVCR) Export Function and Its Dependence on Hemopexin by Yang, Zhantao, Philips, John D., Doty, Raymond T., Giraudi, Pablo, Ostrow, J. Donald, Tiribelli, Claudio, Smith, Ann, Abkowitz, Janis L.

“…The feline leukemia virus subgroup C receptor (FLVCR) is a heme export protein that is required for proerythroblast survival and facilitates macrophage heme…”
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Physico-chemical characterization of bilirubin-10-sulfonate and comparison of its acid–base behavior with unconjugated bilirubin by Čepa, Adam, Dejmková, Veronika, Lešetický, Ladislav, Jelínek, Ivan, Smrček, Stanislav, Štícha, Martin, Jašprová, Jana, Urbanová, Marie, Goncharova, Iryna, Dračínský, Martin, Procházková, Eliška, Ostrow, Donald J., Vítek, Libor

“…Unconjugated bilirubin (UCB) is the end-product of heme catabolism in the intravascular compartment. Although beneficial for human health when mildly elevated…”
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Highly sensitive method for quantitative determination of bilirubin in biological fluids and tissues by Zelenka, Jaroslav, Leníček, Martin, Muchová, Lucie, Jirsa, Milan, Kudla, Michal, Balaž, Peter, Zadinová, Marie, Ostrow, J. Donald, Wong, Ronald J., Vítek, Libor

“…Unconjugated bilirubin (UCB) exhibits potent antioxidant and cytoprotective properties, but causes apoptosis and cytotoxicity at pathologically elevated…”
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The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1 by Corich, Lucia, Aranda, Alejandro, Carrassa, Laura, Bellarosa, Cristina, Ostrow, J Donald, Tiribelli, Claudio

“…In vitro and in vivo studies have demonstrated that UCB (unconjugated bilirubin) is neurotoxic. Although previous studies suggested that both MRP1 (multidrug…”
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The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin by Rigato, Igino, Pascolo, Lorella, Fernetti, Cristina, Ostrow, J Donald, Tiribelli, Claudio

“…Results of previous studies have suggested that UCB (unconjugated bilirubin) may be transported by MRP1/Mrp1 (multidrug-resistance-associated protein 1). To…”
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Bilirubin Protects Astrocytes from Its Own Toxicity by Inducing Up-Regulation and Translocation of Multidrug Resistance-Associated Protein 1 (Mrp1) by Gennuso, Florinda, Fernetti, Cristina, Tirolo, Cataldo, Testa, Nuccio, L'Episcopo, Francesca, Caniglia, Salvo, Morale, Maria Concetta, Ostrow, J. Donald, Pascolo, Lorella, Tiribelli, Claudio, Marchetti, Bianca, Schmid, Rudi

“…Unconjugated bilirubin (UCB) causes encephalopathy in severely jaundiced neonates by damaging astrocytes and neurons. Astrocytes, which help defend the brain…”
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Reassessment of the unbound concentrations of unconjugated bilirubin in relation to neurotoxicity in vitro by OSTROW, J. Donald, PASCOLO, Lorella, TIRIBELLI, Claudio

“…Most studies of the cellular toxicity of unconjugated bilirubin (UCB) have been performed at concentrations of unbound UCB (BF) that exceed those in the plasma…”
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Mortality outcomes after busulfan-containing conditioning treatment and haemopoietic cell transplantation in patients with Gilbert's syndrome: a retrospective cohort study by McDonald, George B, Prof, Evans, Ashley T, MD, McCune, Jeannine S, Prof, Schoch, Gary, BSc, Ostrow, J Donald, Prof, Gooley, Ted A, Prof

“…Summary Background Gilbert's syndrome is a common inherited disorder of bilirubin metabolism, characterised by mild, unconjugated hyperbilirubinaemia. However,…”
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Bilirubin and the risk of common non-hepatic diseases by Rigato, Igino, Ostrow, J. Donald, Tiribelli, Claudio

“…Bilirubin is a potent antioxidant but can be toxic at high concentrations. This article critically reviews the reported relationships of plasma bilirubin…”
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Effect of bilirubin on cytochrome c oxidase activity of mitochondria from mouse brain and liver by Malik, Safarina G, Irwanto, K Astrid, Ostrow, J Donald, Tiribelli, Claudio

“…The unbound, free concentration (Bf) of unconjugated bilirubin (UCB), and not the total UCB level, has been shown to correlate with bilirubin cytotoxicity, but…”
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Mechanisms of bilirubin neurotoxicity by Ostrow, J. Donald, Pascolo, Lorella, Tiribelli, Claudio

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Vagaries of impaired transporter function in PFIC 2 and 3 by Ostrow, J Donald, Tiribelli, Claudio

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Molecular basis of bilirubin-induced neurotoxicity by Ostrow, J Donald, Pascolo, Lorella, Brites, Dora, Tiribelli, Claudio

“…Unconjugated bilirubin (UCB), at slightly elevated unbound concentrations, is toxic to astrocytes and neurons, damaging mitochondria (causing impaired energy…”
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The molecular basis of bilirubin encephalopathy and toxicity: Report of an EASL Single Topic Conference, Trieste, Italy, 1–2 October, 2004 by Tiribelli, Claudio, Ostrow, J. Donald

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Cytotoxicity is predicted by unbound and not total bilirubin concentration by CALLIGARIS, Sebastian D, BELLAROSA, Cristina, GIRAUDI, Pablo, WENNBERG, Richard P, OSTROW, J. Donald, TIRIBELLI, Claudio

“…Although it has been suggested that the unbound, free, (B(f)) rather than total (B(T)) bilirubin level correlates with cell toxicity, direct experimental…”
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Intestinal flora and bilirubin by Tiribelli, Claudio, Ostrow, J. Donald

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