Search Results - "Ostrovskaia, R U"

The original nootropic and neuroprotective drug noopept potentiates the anticonvulsant activity of valproate in mice by Kravchenko, E V, Ponteleeva, I V, Trofimov, S S, Lapa, V I, Ostrovskaia, R U, Voronina, T A

“…The influence of the original dipeptide drug noopept, known to possess nootrope, neuroprotector, and anxiolytic properties, on the anticonvulsant activity of…”
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Hypocoagulant effect of the novel dipeptide NGF mimetic GK-2 by Ozerova, I V, Liutova, L V, Ostrovskaia, R U, Gudasheva, T A, Seredenin, S B

“…The effect of an original dimeric dipeptide NGF mimetic, GK-2 (hexamethylenediamide bis-N-monosuccinyl-L-glutamyl-L-lysine, designed on the basis of the…”
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The study of procognitive effect of the potential antipsychotic, Dilept and its main metabolite, GZR-125 at the novel objects recognition test in rats by Gorelov, P I, Ostrovskaia, R U, Sazonova, N M

“…The effect of dipeptidal neurotensine mimetic, N-caproyl-L-prolyl-L-tyrosine methyl ester (GZR-123, Dilept) and its main metabolite…”
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The search of small molecules with antipsychotic activity on the background of neurotensin by Ostrovskaia, R U, Gudasheva, T A, Krupina, N A, Seredin, S B

“…Tridecapeptide neurotensin (NT) is known to exert the neuroleptic-like effects in case of its intracerebral administration. The group of systemically active…”
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The efficacy of human NGF dipeptide mimetic on the streptozotocin-induced model of diabetes in rats by Ozerova, I V, Povarnina, P Iu, Ostrovskaia, R U, Gudasheva, T A, Voronina, T A, Seredin, S B

“…The effect of a new dimeric dipeptide mimetic GK-2 of the loop-4 human NGF (hexamethylendiamide-bis-N-monosuccinyl-glycil-L-lysine) was investigated for the…”
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Evolution of the neuroprotection concept by Ostrovskaia, R U

“…Although the modern concept of neuroprotection has been formulated quite recently, the basis of this approach was laid about four decades ago when Zakusov…”
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Effect of the novel nootropic and neuroprotective dipeptide noopept on the streptozotocin-induced model of sporadic Alzheimer disease in rats by Ostrovskaia, R U, Tsaplina, A P, Vakhitova, Iu V, Salimgareeva, M Kh, Iamidanov, R S

“…Streptozotocin-intracerebroventricularly treated rats are proposed as an experimental model of sporadic Alzheimer disease (AD). Diabetogenic toxin…”
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Neuroprotective effects of a dipeptide mimetic on the GK-2 nerve growth factor in model of permanent common carotid artery occlusion in rats by Povarina, P Iu, Gudasheva, T A, Vorontsova, O N, Nikolaev, S V, Antipova, T A, Ostrovskaia, R U, Seredin, S B

“…The behavioral and biochemical effects of a new dipeptide mimetic of the GK-2 nerve growth factor (NGF) have been studied on a model of chronic cerebral…”
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Neurotensine dipeptide analog dilept decreases the deficiency of prestimulus startle reflex inhibition: a prognostic sign of antipsychotic activity by Ostrovskaia, R U, Krupina, N A, Gudasheva, T A, Voronina, T A, Seredenin, S B

“…The antipsychotic properties of dilept, a new drug representing substituted dipeptide based on a beta-rotational structure of the main metabolite of endogenous…”
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Analysis of passive avoidance learning in a modified three-compartment setup by Inozemtsev, A N, Bel'nik, A P, Ostrovskaia, R U

“…Passive avoidance conditioning is analyzed in a three-compartment apparatus comprising the central light compartment, the dark dangerous compartment in which…”
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Effect of dipeptide neurotensin analog dilept on extracellular concentrations of glutamate, GABA and HVA in N. accumbens of rat brain by Shubenina, E V, Kudrin, V S, Klodt, P M, Narkevich, V B, Gudasheva, T A, Ostrovskaia, R U

“…The influence of dilept (GZR-123, N-caproyl-L-prolyl-L-tyrosine methyl ester)--a dipeptide analog of neurotensin (NT)--on extracellular concentration of…”
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On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines by Ostrovskaia, R U, Vakhitova, Iu V, Salimgareeva, M Kh, Iamidanov, R S, Sadovnikov, S V, Kapitsa, I G, Seredenin, S B

“…The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of…”
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Experimental pharmacokinetics of the new neurotensine-derived antipsychotic drug dilept by Zherdev, V P, Boĭko, S S, Mesonzhnik, N V, Appolonova, S A, Rodchenkov, G N, Ostrovskaia, R U, Gudasheva, T A, Seredenin, S B

“…The metabolism and pharmacokinetics of a new neurotensine-derived dipeptide drug dilept (N-caproyl-L-prolyltyrosine methyl ester) and its tentative metabolites…”
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Behavior of mice from different strains: modifications produced by noopept by Bel'nik, A P, Ostrovskaia, R U, Poletaeva, I I

“…Genotype-dependent behavioral effects were demonstrated in BALB/c, C57BL/6J [Russian character: see text] DBA/2J mice after injections of nootropic drug…”
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Genotype-dependent mice behavior in cognitive tasks. Effect of noopept by Bel'nik, A P, Ostrovskaia, R U, Poletaeva, I I

“…The interstrain differences in performance of C57BL/6J, BALB/c and DBA/2J male mice in two cognitive tasks were found. Mice C57BL/6J showed good learning…”
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Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept by Shubenina, E B, Kudrin, V S, Klodt, P M, Pokrovskiĭ, A A, Gudasheva, T A, Voronina, T A, Ostrovskaia, R U

“…We have performed a comparative study of the content of glutamate (Glu), aspartate (Asp), taurine (Tau), glycine (Gly) and gamma-amino-butyric acid (GABA) in…”
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Neuroprotective activity of the proline-containing dipeptide noopept on the model of brain ischemia induced by the middle cerebral artery occlusion by Gavrilova, S A, Us, K S, Ostrovskaia, R U, Koshelev, V B

“…The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) on the extent of ischemic cortical stroke was investigated in experiments on…”
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The new tripeptoid neurotensin analog dilept selectively affects dopamine turnover in nucleus accumbens and hypothalamus by Retiunskaia, M V, Kudrin, V S, Klodt, P M, Us, K S, Gudasheva, T A, Ostrovskaia, R U

“…The effects of dilept (N-caproyl-L-prolyl-L-tyrosine methyl ester) - a new peptidomimetic of neurotensine - on the level of monoamines and their main…”
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Decrease in the glutamate release may contribute to the neuroprotective action of the novel neuroleptic drug dilept by Us, K S, Klodt, P M, Kudrin, V S, Arkhipenko, N V, Gudasheva, T A, Ostrovskaia, R U

“…Dilept (GZR-123, N-caproyl-L-prolyl-L-tyrosine methyl ester), designed and synthesized at the Zakusov Institute of Pharmacology, was chosen as one of the most…”
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Dilept: a tripeptoid neurotensin analog combining neuroleptic activity with positive mnemotropic action by Ostrovskaia, R U, Retiunskaia, M V, Guzevatykh, L S, Gudasheva, T A, Voronina, T A, Seredin, S B

“…The effect of N-caproyl-L-prolyl-L-tyrosine methyl ester (GZR-123, Dilept), a new antipsychotic drug with a dipeptide structure, on cognitive functions was…”
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