Search Results - "Ostroff, Linnaea E."

Molecular Mechanisms of Fear Learning and Memory by Johansen, Joshua P., Cain, Christopher K., Ostroff, Linnaea E., LeDoux, Joseph E.

“…Pavlovian fear conditioning is a particularly useful behavioral paradigm for exploring the molecular mechanisms of learning and memory because a well-defined…”
Get full text

CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation by De Rubeis, Silvia, Pasciuto, Emanuela, Li, Ka Wan, Fernández, Esperanza, Di Marino, Daniele, Buzzi, Andrea, Ostroff, Linnaea E., Klann, Eric, Zwartkruis, Fried J.T., Komiyama, Noboru H., Grant, Seth G.N., Poujol, Christel, Choquet, Daniel, Achsel, Tilmann, Posthuma, Danielle, Smit, August B., Bagni, Claudia

“…The CYFIP1/SRA1 gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia…”
Get full text

Inhibition of fear by learned safety signals: a mini-symposium review by Christianson, John P, Fernando, Anushka B P, Kazama, Andy M, Jovanovic, Tanja, Ostroff, Linnaea E, Sangha, Susan

“…Safety signals are learned cues that predict the nonoccurrence of an aversive event. As such, safety signals are potent inhibitors of fear and stress…”
Get full text

Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP by Smith, Heather L, Bourne, Jennifer N, Cao, Guan, Chirillo, Michael A, Ostroff, Linnaea E, Watson, Deborah J, Harris, Kristen M

“…Mitochondria support synaptic transmission through production of ATP, sequestration of calcium, synthesis of glutamate, and other vital functions…”
Get full text

Synapses lacking astrocyte appear in the amygdala during consolidation of pavlovian threat conditioning by Ostroff, Linnaea E., Manzur, Mustfa K., Cain, Christopher K., Ledoux, Joseph E.

“…ABSTRACT There is growing evidence that astrocytes, long held to merely provide metabolic support in the adult brain, participate in both synaptic plasticity…”
Get full text

Shifting patterns of polyribosome accumulation at synapses over the course of hippocampal long‐term potentiation by Ostroff, Linnaea E., Watson, Deborah J., Cao, Guan, Parker, Patrick H., Smith, Heather, Harris, Kristen M.

“…Hippocampal long‐term potentiation (LTP) is a cellular memory mechanism. For LTP to endure, new protein synthesis is required immediately after induction and…”
Get full text

Fear and safety learning differentially affect synapse size and dendritic translation in the lateral amygdala by Ostroff, Linnaea E, Cain, Christopher K, Bedont, Joseph, Monfils, Marie H, LeDoux, Joseph E

“…Fear learning is associated with changes in synapse strength in the lateral amygdala (LA). To examine changes in LA dendritic spine structure with learning, we…”
Get full text

Automated classification of estrous stage in rodents using deep learning by Wolcott, Nora S., Sit, Kevin K., Raimondi, Gianna, Hodges, Travis, Shansky, Rebecca M., Galea, Liisa A. M., Ostroff, Linnaea E., Goard, Michael J.

“…The rodent estrous cycle modulates a range of biological functions, from gene expression to behavior. The cycle is typically divided into four stages, each…”
Get full text

Stability of presynaptic vesicle pools and changes in synapse morphology in the amygdala following fear learning in adult rats by Ostroff, Linnaea E., Cain, Christopher K., Jindal, Neha, Dar, Najia, Ledoux, Joseph E.

“…Changes in synaptic strength in the lateral amygdala (LA) that occur with fear learning are believed to mediate memory storage, and both presynaptic and…”
Get full text

Persistent Up-Regulation of Polyribosomes at Synapses during Long-Term Memory, Reconsolidation, and Extinction of Associative Memory by Ostroff, Linnaea E, Cain, Christopher K

“…Local protein synthesis at synapses can provide a rapid supply of proteins to support synaptic changes during consolidation of new memories, but its role in…”
Get full text

Track-by-Day: A standardized approach to estrous cycle monitoring in biobehavioral research by Raimondi, Gianna M, Eng, Ashley K, Kenny, Murphy P, Britting, Madison A, Ostroff, Linnaea E

“…Despite known sex differences in brain function, female subjects are underrepresented in preclinical neuroscience research. This is driven in part by concerns…”
Get full text

Rehydration of Freeze Substituted Brain Tissue for Pre-embedding Immunoelectron Microscopy by Pérez-Garza, Janeth, Parrish-Mulliken, Emily, Deane, Zachary, Ostroff, Linnaea E

“…Electron microscopy (EM) volume reconstruction is a powerful tool for investigating the fundamental structure of brain circuits, but the full potential of this…”
Get more information

Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation by Ostroff, Linnaea E, Botsford, Benjamin, Gindina, Sofya, Cowansage, Kiriana K, LeDoux, Joseph E, Klann, Eric, Hoeffer, Charles

“…Translation in dendrites is believed to support synaptic changes during memory consolidation. Although translational control mechanisms are fundamental…”
Get full text

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala by Ostroff, Linnaea E, Santini, Emanuela, Sears, Robert, Deane, Zachary, Kanadia, Rahul N, LeDoux, Joseph E, Lhakhang, Tenzin, Tsirigos, Aristotelis, Heguy, Adriana, Klann, Eric

“…Local translation can support memory consolidation by supplying new proteins to synapses undergoing plasticity. Translation in adult forebrain dendrites is an…”
Get full text

The Track-by-Day Method for Monitoring the Rodent Estrous Cycle by Raimondi, Gianna M, Tripp, Rebecca, Ostroff, Linnaea E

“…The exclusion of female subjects from preclinical neuroscience research has traditionally been justified in part by concerns about potential effects of cycling…”
Get more information

Polyribosomes Redistribute from Dendritic Shafts into Spines with Enlarged Synapses during LTP in Developing Rat Hippocampal Slices by Ostroff, Linnaea E, Fiala, John C, Allwardt, Brenda, Harris, Kristen M

“…The presence of polyribosomes in dendritic spines suggests a potential involvement of local protein synthesis in the modification of synapses. Dendritic spine…”
Get full text

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala by Ostroff, Linnaea E, Santini, Emanuela, Sears, Robert, Deane, Zachary, Kanadia, Rahul N, LeDoux, Joseph E, Lhakhang, Tenzin, Tsirigos, Aristotelis, Heguy, Adriana, Klann, Eric

“…Local translation can support memory consolidation by supplying new proteins to synapses undergoing plasticity. Translation in adult forebrain dendrites is an…”
Get full text

Molecular Mechanisms of Fear Learning and Memory by Johansen, Joshua P., Cain, Christopher K., Ostroff, Linnaea E., LeDoux, Joseph E.

Get full text

Cover Image, Volume 28, Issue 6 by Ostroff, Linnaea E., Watson, Deborah J., Cao, Guan, Parker, Patrick H., Smith, Heather, Harris, Kristen M.

Get full text