Microstructural and strength evaluation of regenerate tissue during the consolidation period after vertical mandibular ramus distraction

Microstructural and strength evaluation of regenerate tissue during the consolidation period after vertical mandibular ramus distraction

Mandibular ramus height restoration by distraction osteogenesis (DO) is a key procedure in mandibular hypoplasia reconstruction. The objective of this study was to evaluate short-term skeletal changes in the regenerated bone after vertical mandibular ramus DO using a buried distraction device. Eight...

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Bibliographic Details
Published in:The Journal of craniofacial surgery Vol. 16; no. 5; pp. 805 - 811
Main Authors: Gomez, David F, Sant'Anna, Eduardo F, Leven, Robert M, Ostric, Sjdran A, Figueroa, Alvaro A, Royston, Thomas J, Sumner, Dale R, Polley, John W
Format: Journal Article
Language:English
Published: United States 01-09-2005
Subjects:
Animals
Bone Density - physiology
Bone Regeneration - physiology
Calcification, Physiologic - physiology
Dentistry
Dogs
Internal Fixators
Male
Mandible - physiology
Mandible - surgery
Mandible - ultrastructure
Mandibular Nerve - anatomy & histology
Microradiography
Models, Animal
Osteogenesis - physiology
Osteogenesis, Distraction - instrumentation
Stress, Mechanical
Time Factors
Tomography, X-Ray Computed - methods
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Summary:Mandibular ramus height restoration by distraction osteogenesis (DO) is a key procedure in mandibular hypoplasia reconstruction. The objective of this study was to evaluate short-term skeletal changes in the regenerated bone after vertical mandibular ramus DO using a buried distraction device. Eight subadult beagle dogs underwent bilateral vertical mandibular ramus DO. After a 7-day latency period, distraction was performed at a rate of 0.5 mm twice a day for 12 days. Four dogs were killed at 1 month and four dogs at 2 months after the end of distraction. One intact beagle was included as an unoperated control. After sacrifice, micro computed tomography (muCT) and mechanical testing of distracted sites were used to measure bone volume (BV), total volume (TV), and mechanical peak load strength, respectively. The muCT images showed wide variation in the response, with some animals demonstrating considerable bone formation and reconstitution of the canal for the inferior alveolar nerve. Quantitatively, BV was no more than 67% and BV/TV was less than 25% of the intact control, and strength was approximately 33% of the intact control value. The 1 and 2 month values were similar. These results suggest that internal distractors can successfully reconstitute bone but that the regenerated tissue did not regain structural and mechanical characteristics of native bone within the 2 month study period.
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ISSN:1049-2275
DOI:10.1097/01.scs.0000179663.76289.78