Search Results - "Ostrem, M"

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design by Ostrem, Jonathan M. L., Shokat, Kevan M.

“…Key Points The small GTPase KRAS is among the most frequently activated proteins in cancer. Despite this, extensive efforts to target KRAS over the past…”
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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions by Ostrem, Jonathan M., Peters, Ulf, Sos, Martin L., Wells, James A., Shokat, Kevan M.

“…Small molecules are developed that irreversibly bind to the common G12C mutant of K-Ras but not the wild-type protein; crystallographic studies reveal the…”
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Direct RAS inhibitors turn 10 by Ostrem, Jonathan M. L., Peters, Ulf, Shokat, Kevan M.

“…RAS proteins, central drivers of cancer, appeared ‘undruggable’ for almost 30 years. Here we provide a personal perspective on the effort leading to our…”
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Bioremediation and microbial metabolism of benzo(a)pyrene by Ostrem Loss, Erin M., Yu, Jae‐Hyuk

“…Summary The growing release of organic contaminants into the environment due to industrial processes has inevitably increased the incidence of their exposure…”
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Systematic Dissection of the Evolutionarily Conserved WetA Developmental Regulator across a Genus of Filamentous Fungi by Wu, Ming-Yueh, Mead, Matthew E, Lee, Mi-Kyung, Ostrem Loss, Erin M, Kim, Sun-Chang, Rokas, Antonis, Yu, Jae-Hyuk

“…Asexual sporulation is fundamental to the ecology and lifestyle of filamentous fungi and can facilitate both plant and human infection. In , the production of…”
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A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region by Schroeder, Courtney M, Ostrem, Jonathan M L, Hertz, Nicholas T, Vale, Ronald D

“…Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means of its light intermediate chain (LIC). In this study, we…”
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Cytochrome P450 Monooxygenase-Mediated Metabolic Utilization of Benzo[ a ]Pyrene by Aspergillus Species by Ostrem Loss, Erin M, Lee, Mi-Kyung, Wu, Ming-Yueh, Martien, Julia, Chen, Wanping, Amador-Noguez, Daniel, Jefcoate, Colin, Remucal, Christina, Jung, Seunho, Kim, Sun-Chang, Yu, Jae-Hyuk

“…Soil-dwelling fungal species possess the versatile metabolic capability to degrade complex organic compounds that are toxic to humans, yet the mechanisms they…”
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Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations by Liu, Shuang, Tong, Bingqi, Mason, Jeremy W., Ostrem, Jonathan M., Tutter, Antonin, Hua, Bruce K., Tang, Sunny A., Bonazzi, Simone, Briner, Karin, Berst, Frédéric, Zécri, Frédéric J., Schreiber, Stuart L.

“…The hallmark of a molecular glue is its ability to induce cooperative protein–protein interactions, leading to the formation of a ternary complex, despite…”
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Microbial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut by Quinn-Bohmann, Nick, Wilmanski, Tomasz, Sarmiento, Katherine Ramos, Levy, Lisa, Lampe, Johanna W., Gurry, Thomas, Rappaport, Noa, Ostrem, Erin M., Venturelli, Ophelia S., Diener, Christian, Gibbons, Sean M.

“…Microbially derived short-chain fatty acids (SCFAs) in the human gut are tightly coupled to host metabolism, immune regulation and integrity of the intestinal…”
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4CPS-266 Detection and follow-up of drug-related problems for patients with cardiovascular disease: a study of the Medicine Start Service in hospital pharmacies by Cuevas-Østrem, ML, Bøvre, K, Andersson, Y, Bjerknes, K

“…Background and importanceMedication treatment of cardiovascular disease (CVD) commonly consists of multiple drugs in long-term use, which efficiently reduces…”
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Differential cell adhesion to vocal fold extracellular matrix constituents by Fuja, Tannin J., Ostrem, Erin M., Probst-Fuja, Megan N., Titze, Ingo R.

“…The human vocal folds are a complex layering of cells and extracellular matrix. Vocal fold extracellular matrix uniquely contributes to the biomechanical…”
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Pricing Strategies in the Restaurant Industry by Heide, Morten, White, Camilla, Grønhaug, Kjell, Østrem, Terje M.

“…Pricing is known by economists and managers to be an important tool for increasing revenue and thereby ensuring the success of the company. However, practical…”
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Cytochrome P450 Monooxygenase-Mediated Metabolic Utilization of Benzo[ italic toggle="yes">a /italic>]Pyrene by italic toggle="yes">Aspergillus /italic> Species by Erin M. Ostrem Loss, Mi-Kyung Lee, Ming-Yueh Wu, Julia Martien, Wanping Chen, Daniel Amador-Noguez, Colin Jefcoate, Christina Remucal, Seunho Jung, Sun-Chang Kim, Jae-Hyuk Yu

“…ABSTRACT Soil-dwelling fungal species possess the versatile metabolic capability to degrade complex organic compounds that are toxic to humans, yet the…”
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Targeting KRAS G12C with Covalent Inhibitors by Ostrem, Jonathan M.L, Shokat, Kevan M

“…KRAS is the most frequently mutated oncogene in cancer. Following numerous attempts to inhibit KRAS spanning multiple decades, recent efforts aimed at…”
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Mapping and Measuring Social Disparities in Premature Mortality: The Impact of Census Tract Poverty within and Across Boston Neighborhoods, 1999–2001 by Chen, J T, Rehkopf, D H, Waterman, P D, Subramanian, S V, Coull, B A, Cohen, B, Ostrem, M, Krieger, N

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Abstract A180: Selective inhibition of K-Ras G12C through allosteric control of GTP affinity and effector interactions by Peters, Ulf, Ostrem, Jonathan M., Sos, Martin L., Wells, James A., Shokat, Kevan M.

“…Abstract Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor…”
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Abstract PL04-03: Selective inhibition of K-Ras G12C through allosteric control of GTP affinity and effector interactions by Ostrem, Jonathan M., Peters, Ulf, Sos, Martin L., Wells, James A., Shokat, Kevan M.

“…Abstract Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor…”
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Abstract LB-311: Development of mutant-specific small molecule inhibitors of K-Ras by Ostrem, Jonathan M., Peters, Ulf, Ren, Pingda, Liu, Yi, Wells, James A., Shokat, Kevan M.

“…Abstract Activating mutations in K-Ras are among the most common lesions found in human cancer, and such mutations are generally associated with poor…”
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The Prevalence of Blood Pressure and Cholesterol Monitoring in Boston Among Non-Hispanic Blacks, Hispanics, and Non-Hispanic Whites by Stuart-Shor, Eileen M., Nannini, Angela, Ostrem, Mary, Russell, Gail E., Mittleman, Murray A.

“…Racial and ethnic minorities are at increased risk for hypertension and hypercholesterolemia. Appropriate blood pressure and cholesterol monitoring is a…”
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Analyzing teenage births by school district by Gould, J.B, Ostrem, M, Davey, B

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