Search Results - "Ostrega, D"

Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism by Zhou, Y P, Teng, D, Dralyuk, F, Ostrega, D, Roe, M W, Philipson, L, Polonsky, K S

“…This study investigated the role of intracellular free Ca2+ concentration ([Ca2+]i) in apoptosis in MIN6 cells, an insulin secreting cell line, and in mouse…”
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Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance by Reaven, G M, Chen, Y D, Hollenbeck, C B, Sheu, W H, Ostrega, D, Polonsky, K S

“…Conventional immunoassays to quantify insulin concentration do not differentiate between insulin and proinsulin. Thus, previous conclusions as to the…”
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Calpains Play a Role in Insulin Secretion and Action by SREENAN, Seamus K, ZHOU, Yun-Ping, COX, Nancy J, HANIS, Craig L, BURANT, Charles F, FOX, Aaron P, BELL, Graeme I, POLONSKY, Kenneth S, OTANI, Kenichi, HANSEN, Polly A, CURRIE, Kevin P. M, PAN, Chien-Yuan, LEE, Jean-Pyo, OSTREGA, Diane M, PUGH, William, HORIKAWA, Yukio

“…Calpains Play a Role in Insulin Secretion and Action Seamus K. Sreenan 1 , Yun-Ping Zhou 1 , Kenichi Otani 1 8 , Polly A. Hansen 6 , Kevin P.M. Currie 2 ,…”
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Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat by Sturis, J, Pugh, W.L, Tang, J, Ostrega, D.M, Polonsky, J.S, Polonsky, K.S

“…Insulin secretion from the isolated perfused pancreas is characterized by pulses occurring every 5-15 min. The present experiments were performed to explore…”
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Measurement of proinsulin and intermediates. Validation of immunoassay methods by high-performance liquid chromatography by Ostrega, D., Polonsky, K., Nagi, D., Yudkin, J., Cox, L. J., Clark, P. M., Hales, C. N.

“…Measurement of proinsulin and intermediates. Validation of immunoassay methods by high-performance liquid chromatography. D Ostrega , K Polonsky , D Nagi , J…”
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Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes by Cockburn, B. N., Ostrega, D. M., Sturis, J., Kubstrup, C., Polonsky, K. S., Bell, G. I.

“…Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes. B N Cockburn , D M Ostrega , J…”
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Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes by COCKBURN, B. N, OSTREGA, D. M, STURIS, J, KUBSTRUP, C, POLONSKY, K. S, BELL, G. I

“…We examined changes in high- and low-Km glucose phosphorylating activity in pancreatic islet extracts from the prediabetic Zucker diabetic fatty (ZDF) rat…”
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Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM by Polonsky, K. S., Gumbiner, B., Ostrega, D., Griver, K., Tager, H., Henry, R. R.

“…Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM. K S Polonsky , B Gumbiner , D Ostrega , K Griver , H Tager and…”
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Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice by SREENAN, S. K, COCKBURN, B. N, BALDWIN, A. C, OSTREGA, D. M, LEVISETTI, M, GRUPE, A, BELL, G. I, STEWART, T. A, ROE, M. W, POLONSKY, K. S

“…Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice. S K Sreenan , B N Cockburn , A C Baldwin , D M Ostrega , M Levisetti , A…”
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Islet isolation under cGMP conditions: replacing the coil by Garfinkel, M.R, Connors, M, Ostrega, D, Jarosz, J, Philipson, L, Millis, J.M

“…Clinical islet transplantation is increasingly regulated, with isolation standards defined under current good manufacturing practices (cGMPs). cGMP requires…”
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Alterations in the patterns of insulin secretion before and after diagnosis of IDDM by O'MEARA, N. M, STURIS, J, HEROLD, K. C, OSTREGA, D. M, POLONSKY, K. S

“…Alterations in the patterns of insulin secretion before and after diagnosis of IDDM. N M O'Meara , J Sturis , K C Herold , D M Ostrega and K S Polonsky…”
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Encapsulation of pancreatic islets within nano-thin functional polyethylene glycol coatings for enhanced insulin secretion by Kizilel, Seda, Scavone, Andrew, Liu, Xiang, Nothias, Jean-Manuel, Ostrega, Diane, Witkowski, Piotr, Millis, Michael

“…Covalent attachment of polymers to cells and tissues could be used to solve a variety of problems associated with cellular therapies. Insulin-dependent…”
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Hypoglycemia due to surreptitious injection of insulin. Identification of insulin species by high-performance liquid chromatography by B D Given, D M Ostrega, K S Polonsky, D Baldwin, Jr, R I Kelley, A H Rubenstein

“…Hypoglycemia due to surreptitious injection of insulin. Identification of insulin species by high-performance liquid chromatography. B D Given , D M Ostrega ,…”
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Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice by Pontoglio, M, Sreenan, S, Roe, M, Pugh, W, Ostrega, D, Doyen, A, Pick, A J, Baldwin, A, Velho, G, Froguel, P, Levisetti, M, Bonner-Weir, S, Bell, G I, Yaniv, M, Polonsky, K S

“…Mutations in the gene for the transcription factor hepatocyte nuclear factor (HNF) 1alpha cause maturity-onset diabetes of the young (MODY) 3, a form of…”
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Ingestion of a mixed meal does not affect the metabolic clearance rate of biosynthetic human C-peptide by Licinio-Paixao, J, Polonsky, K S, Given, B D, Pugh, W, Ostrega, D, Frank, B F, Rubenstein, A H

“…The validity of C-peptide as a peripheral marker of insulin secretion during different physiological conditions depends on the demonstration that C-peptide…”
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Defective Pancreatic β-Cell Glycolytic Signaling in Hepatocyte Nuclear Factor-1α-deficient Mice by Dukes, Iain D., Sreenan, Seamus, Roe, Michael W., Levisetti, Matteo, Zhou, Yun-Ping, Ostrega, Diane, Bell, Graeme I., Pontoglio, Marco, Yaniv, Moshe, Philipson, Louis, Polonsky, Kenneth S.

“…Mutations in the hepatocyte nuclear factor-1α (HNF-1α) gene cause maturity onset diabetes of the young type 3, a form of type 2 diabetes mellitus. In mice…”
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Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion by Zhou, Y P, Pena, J C, Roe, M W, Mittal, A, Levisetti, M, Baldwin, A C, Pugh, W, Ostrega, D, Ahmed, N, Bindokas, V P, Philipson, L H, Hanahan, D, Thompson, C B, Polonsky, K S

“…To study effects of Bcl-x(L) in the pancreatic beta-cell, two transgenic lines were produced using different forms of the rat insulin promoter. Bcl-x(L)…”
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A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin by Zhou, Yun-Ping, Sreenan, Seamus, Pan, Chien-Yuan, Currie, Kevin P.M., Bindokas, Vytautas P., Horikawa, Yukio, Lee, Jean-Pyo, Ostrega, Diane, Ahmed, Noreen, Baldwin, Aaron C., Cox, Nancy J., Fox, Aaron P., Miller, Richard J., Bell, Graeme I., Polonsky, Kenneth S.

“…Genetic variation in the gene for a cytosolic cysteine protease, calpain-10, increases the susceptibility to type 2 diabetes apparently by altering levels of…”
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Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM by POLONSKY, K. S, GUMBINER, B, OSTREGA, D, GRIVER, K, TAGER, H, HENRY, R. R

“…Subjects with overt non-insulin-dependent diabetes mellitus (NIDDM) were studied in comparison to obese nondiabetic control subjects and patients with…”
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A novel point mutation in the insulin gene giving rise to hyperproinsulinemia by WARREN-PERRY, M. G, MANLEY, S. E, OSTREGA, D, POLONSKY, K, MUSSETT, S, BROWN, P, TURNER, R. C

“…A 58-yr-old obese white Caucasian male type 2 diabetic, entered into the UK Prospective Diabetes Study, was found to have raised fasting total proinsulin…”
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