Search Results - "Ostrand‐Rosenberg, Suzanne"

Frontline Science: High fat diet and leptin promote tumor progression by inducing myeloid‐derived suppressor cells by Clements, Virginia K., Long, Tiha, Long, Ramses, Figley, Chas, Smith, Daniel M.C., Ostrand‐Rosenberg, Suzanne

“…Obesity is a risk factor for cancer incidence and cancer mortality. The association of obesity and cancer is attributed to multiple factors, but the tightest…”
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Cross‐talk among myeloid‐derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors by Beury, Daniel W., Parker, Katherine H., Nyandjo, Maeva, Sinha, Pratima, Carter, Kayla A., Ostrand‐Rosenberg, Suzanne

“…Interactions between MDSC, macrophages, and tumor cells alter the cytokine milieu, impacting inflammation in the tumor microenvironment. MDSC and macrophages…”
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Frontline Science: Myeloid‐derived suppressor cells (MDSCs) facilitate maternal–fetal tolerance in mice by Ostrand‐Rosenberg, Suzanne, Sinha, Pratima, Figley, Chas, Long, Ramses, Park, DoHwan, Carter, Darryl, Clements, Virginia K.

“…MDSC sustain allogeneic pregnancy in mice by reducing T cell activation, and their induction supports successful implantation and pregnancy in mice compromised…”
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Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4 by Bunt, Stephanie K., Clements, Virginia K., Hanson, Erica M., Sinha, Pratima, Ostrand‐Rosenberg, Suzanne

“…Myeloid‐derived suppressor cells (MDSC) are potent inhibitors of anti‐tumor immunity that facilitate tumor progression by blocking the activation of CD4+ and…”
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Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer by Ostrand-Rosenberg, Suzanne, Sinha, Pratima

“…Many cancer immunotherapies developed in experimental animals have been tested in clinical trials. Although some have shown modest clinical effects, most have…”
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Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity by Pawelec, Graham, Verschoor, Chris P, Ostrand-Rosenberg, Suzanne

“…Since the realization that immature myeloid cells are powerful modulators of the immune response, many studies on "myeloid-derived suppressor cells" (MDSCs)…”
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The programmed death-1 immune-suppressive pathway: barrier to antitumor immunity by Ostrand-Rosenberg, Suzanne, Horn, Lucas A, Haile, Samuel T

“…Programmed death ligand 1 (PD-L1, also known as B7 homolog 1 or CD274) is a major obstacle to antitumor immunity because it tolerizes/anergizes tumor-reactive…”
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Understanding the tumor immune microenvironment (TIME) for effective therapy by Binnewies, Mikhail, Roberts, Edward W., Kersten, Kelly, Chan, Vincent, Fearon, Douglas F., Merad, Miriam, Coussens, Lisa M., Gabrilovich, Dmitry I., Ostrand-Rosenberg, Suzanne, Hedrick, Catherine C., Vonderheide, Robert H., Pittet, Mikael J., Jain, Rakesh K., Zou, Weiping, Howcroft, T. Kevin, Woodhouse, Elisa C., Weinberg, Robert A., Krummel, Matthew F.

“…The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen…”
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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards by Bronte, Vincenzo, Brandau, Sven, Chen, Shu-Hsia, Colombo, Mario P., Frey, Alan B., Greten, Tim F., Mandruzzato, Susanna, Murray, Peter J., Ochoa, Augusto, Ostrand-Rosenberg, Suzanne, Rodriguez, Paulo C., Sica, Antonio, Umansky, Viktor, Vonderheide, Robert H., Gabrilovich, Dmitry I.

“…Myeloid-derived suppressor cells (MDSC) are a heterogeneous population expanded in cancer and other chronic inflammatory conditions. Here the authors identify…”
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High‐mobility group box protein 1 promotes the survival of myeloid‐derived suppressor cells by inducing autophagy by Parker, Katherine H., Horn, Lucas A., Ostrand‐Rosenberg, Suzanne

“…HMGB1 promotes autophagy in MDSC, thereby increasing their survival in the tumor microenvironment. Myeloid‐derived suppressor cells are immune‐suppressive…”
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Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract by Sinha, Pratima, Ostrand-Rosenberg, Suzanne

“…Myeloid cells play a crucial role in tumor progression. The most common tumor-infiltrating myeloid cells are myeloid-derived suppressor cells (MDSC) and…”
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Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells by SINHA, Pratima, CLEMENTS, Virginia K, FULTON, Amy M, OSTRAND-ROSENBERG, Suzanne

“…A causative relationship between chronic inflammation and cancer has been postulated for many years, and clinical observations and laboratory experiments…”
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Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells by Sinha, Pratima, Okoro, Chinonyerem, Foell, Dirk, Freeze, Hudson H, Ostrand-Rosenberg, Suzanne, Srikrishna, Geetha

“…Chronic inflammation is a complex process that promotes carcinogenesis and tumor progression; however, the mechanisms by which specific inflammatory mediators…”
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HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells by Parker, Katherine H, Sinha, Pratima, Horn, Lucas A, Clements, Virginia K, Yang, Huan, Li, Jianhua, Tracey, Kevin J, Ostrand-Rosenberg, Suzanne

“…Chronic inflammation often precedes malignant transformation and later drives tumor progression. Likewise, subversion of the immune system plays a role in…”
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Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response by Sinha, Pratima, Clements, Virginia K, Bunt, Stephanie K, Albelda, Steven M, Ostrand-Rosenberg, Suzanne

“…Although the immune system has the potential to protect against malignancies, many individuals with cancer are immunosuppressed. Myeloid-derived suppressor…”
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Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression by BUNT, Stephanie K, LINGLIN YANG, SINHA, Pratima, CLEMENTS, Virginia K, LEIPS, Jeff, OSTRAND-ROSENBERG, Suzanne

“…Chronic inflammation is frequently associated with malignant growth and is thought to promote and enhance tumor progression, although the mechanisms which…”
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Radiotherapy Both Promotes and Inhibits Myeloid-Derived Suppressor Cell Function: Novel Strategies for Preventing the Tumor-Protective Effects of Radiotherapy by Ostrand-Rosenberg, Suzanne, Horn, Lucas A, Ciavattone, Nicholas G

“…Cancer immunotherapies aimed at neutralizing the programmed death-1 (PD-1) immune suppressive pathway have yielded significant therapeutic efficacy in a subset…”
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Tumor‐induced myeloid‐derived suppressor cell function is independent of IFN‐γ and IL‐4Rα by Sinha, Pratima, Parker, Katherine H., Horn, Lucas, Ostrand‐Rosenberg, Suzanne

“…Myeloid‐derived suppressor cells (MDSCs) are present in most cancer patients and experimental animals where they exert a profound immune suppression and are a…”
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Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2 by Beury, Daniel W, Carter, Kayla A, Nelson, Cassandra, Sinha, Pratima, Hanson, Erica, Nyandjo, Maeva, Fitzgerald, Phillip J, Majeed, Amry, Wali, Neha, Ostrand-Rosenberg, Suzanne

“…Tumor-induced myeloid-derived suppressor cells (MDSC) contribute to immune suppression in tumor-bearing individuals and are a major obstacle to effective…”
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The terminology issue for myeloid-derived suppressor cells by Gabrilovich, Dmitry I, Bronte, Vincenzo, Chen, Shu-Hsia, Colombo, Mario P, Ochoa, Augusto, Ostrand-Rosenberg, Suzanne, Schreiber, Hans

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