Search Results - "Ostling, P."

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion by Björkman, M, Östling, P, Härmä, V, Virtanen, J, Mpindi, J-P, Rantala, J, Mirtti, T, Vesterinen, T, Lundin, M, Sankila, A, Rannikko, A, Kaivanto, E, Kohonen, P, Kallioniemi, O, Nees, M

“…Our understanding of key epigenetic regulators involved in specific biological processes and cancers is still incomplete, despite great progress in genome-wide…”
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Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ by Jin, S, Mutvei, A P, Chivukula, I V, Andersson, E R, Ramsköld, D, Sandberg, R, Lee, K L, Kronqvist, P, Mamaeva, V, Östling, P, Mpindi, J-P, Kallioniemi, O, Screpanti, I, Poellinger, L, Sahlgren, C, Lendahl, U

“…Notch signaling is frequently hyperactivated in breast cancer, but how the enhanced signaling contributes to the tumor process is less well understood. In this…”
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Novel precision medicine approaches and treatment strategies in hematological malignancies by Rosenquist, Richard, Bernard, Elsa, Erkers, Tom, Scott, David W, Itzykson, Raphael, Rousselot, Philippe, Soulier, Jean, Hutchings, Martin, Östling, Päivi, Cavelier, Lucia, Fioretos, Thoas, Smedby, Karin E

“…Genetic testing has been applied for decades in clinical routine diagnostics of hematological malignancies to improve disease (sub)classification,…”
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Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKb by Jin, S, Mutvei, AP, Chivukula, IV, Andersson, ER, Ramskold, D, Sandberg, R, Lee, KL, Kronqvist, P, Mamaeva, V, Ostling, P

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Targeting SAMHD1 with hydroxyurea in first‐line cytarabine‐based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT‐AML trial by Jädersten, Martin, Lilienthal, Ingrid, Tsesmetzis, Nikolaos, Lourda, Magda, Bengtzén, Sofia, Bohlin, Anna, Arnroth, Cornelia, Erkers, Tom, Seashore‐Ludlow, Brinton, Giraud, Géraldine, Barkhordar, Giti S., Tao, Sijia, Fogelstrand, Linda, Saft, Leonie, Östling, Päivi, Schinazi, Raymond F., Kim, Baek, Schaller, Torsten, Juliusson, Gunnar, Deneberg, Stefan, Lehmann, Sören, Rassidakis, Georgios Z., Höglund, Martin, Henter, Jan‐Inge, Herold, Nikolas

“…Background Treatment of newly diagnosed acute myeloid leukaemia (AML) is based on combination chemotherapy with cytarabine (ara‐C) and anthracyclines…”
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High‐content screening of drug combinations of an mPGES‐1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance by Zaghmi, Ahlem, Aybay, Erdem, Jiang, Long, Shang, Mingmei, Steinmetz‐Späh, Julia, Wermeling, Fredrik, Kogner, Per, Korotkova, Marina, Östling, Päivi, Jakobsson, Per‐Johan, Seashore‐Ludlow, Brinton, Larsson, Karin

“…High‐throughput drug screening enables the discovery of new anticancer drugs. Although monolayer cell cultures are commonly used for screening, their limited…”
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Precision systems medicine in urological Tumors – Molecular profiling and functional testing by Saeed, K., Ojamies, P., Pellinen, T., Rahkama, V., Eldfors, S., Paavolainen, L., Turkki, R., Horvath, P., Lundin, J., Nisen, H., af Hällström, T.M., Rannikko, A., Mirtti, T., Kallioniemi, O., Östling, P.

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miR-183 in Prostate Cancer Cells Positively Regulates Synthesis and Serum Levels of Prostate-specific Antigen by Larne, Olivia, Östling, Päivi, Haflidadóttir, Benedikta S, Hagman, Zandra, Aakula, Anna, Kohonen, Pekka, Kallioniemi, Olli, Edsjö, Anders, Bjartell, Anders, Lilja, Hans, Lundwall, Åke, Ceder, Yvonne

“…Abstract Background Factors affecting serum prostate-specific antigen (PSA) levels in men are clinically important, but apart from effects mediated through the…”
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The drug efficacy testing in 3D cultures platform identifies effective drugs for ovarian cancer patients by Åkerlund, Emma, Gudoityte, Greta, Moussaud-Lamodière, Elisabeth, Lind, Olina, Bwanika, Henri Colyn, Lehti, Kaisa, Salehi, Sahar, Carlson, Joseph, Wallin, Emelie, Fernebro, Josefin, Östling, Päivi, Kallioniemi, Olli, Joneborg, Ulrika, Seashore-Ludlow, Brinton

“…Most patients with advanced ovarian cancer (OC) relapse and progress despite systemic therapy, pointing to the need for improved and tailored therapy options…”
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Differential drug sensitivity score (DSS) for indolent and aggressive prostate cancer cell lines by Suominen, M.I, Mäki-Jouppila, J, Bernoulli, J, Tuomela, J, Halleen, J.M, Timonen, S, Huovari, E, Suomi, K, Potdar, S, Ostling, P, Saarela, J, Fagerlund, K.M

“…Background: Prostate cancer (PC) is the most common malignancy in men and the second leading cause of cancer-related deaths. The majority of the PCs are…”
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273: Androgen receptor interacting protein HSPBAP1 facilitates growth of prostate cancer cells in androgen-deficient conditions by Ostling, P, Saeed, K, Björkman, M, Mirtti, T, Vesterinen, T, Lundin, J, Rannikko, A, Mpindi, J.P, Kallioniemi, O, Rantala, J

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684: Helsinki Urological Biobank (HUB): A new-generation integrated biobank for facilitating precision medicine and translational research in urological cancers by Af Hällström, T, Mirtti, T, Saeed, K, Rahkama, V, Puhka, M, Ostling, P, Vesterinen, T, Pitkänen, K, Kallioniemi, O, Rannikko, A

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Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines by Leivonen, S-K, Mäkelä, R, Östling, P, Kohonen, P, Haapa-Paananen, S, Kleivi, K, Enerly, E, Aakula, A, Hellström, K, Sahlberg, N, Kristensen, V N, Børresen-Dale, A-L, Saviranta, P, Perälä, M, Kallioniemi, O

“…Predicting the impact of microRNAs (miRNAs) on target proteins is challenging because of their different regulatory effects at the transcriptional and…”
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Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression by Chang, Yunhua, Ostling, Päivi, Akerfelt, Malin, Trouillet, Diane, Rallu, Murielle, Gitton, Yorick, El Fatimy, Rachid, Fardeau, Vivienne, Le Crom, Stéphane, Morange, Michel, Sistonen, Lea, Mezger, Valérie

“…Heat-shock factors (HSFs) are associated with multiple developmental processes, but their mechanisms of action in these processes remain largely enigmatic…”
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Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines by Leo, Isabelle Rose, Aswad, Luay, Stahl, Matthias, Kunold, Elena, Post, Frederik, Erkers, Tom, Struyf, Nona, Mermelekas, Georgios, Joshi, Rubin Narayan, Gracia-Villacampa, Eva, Östling, Päivi, Kallioniemi, Olli P., Tamm, Katja Pokrovskaja, Siavelis, Ioannis, Lehtiö, Janne, Vesterlund, Mattias, Jafari, Rozbeh

“…Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Although standard-of-care chemotherapeutics are sufficient for most ALL cases, there…”
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Screening out irrelevant cell-based models of disease by Horvath, Peter, Aulner, Nathalie, Bickle, Marc, Davies, Anthony M., Nery, Elaine Del, Ebner, Daniel, Montoya, Maria C., Östling, Päivi, Pietiäinen, Vilja, Price, Leo S., Shorte, Spencer L., Turcatti, Gerardo, von Schantz, Carina, Carragher, Neil O.

“…Traditional cell-based disease models often fail to adequately represent key disease characteristics, increasing the risk of subsequent attrition in clinical…”
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Breeze: an integrated quality control and data analysis application for high-throughput drug screening by Potdar, Swapnil, Ianevski, Aleksandr, Mpindi, John-Patrick, Bychkov, Dmitrii, Fiere, Clément, Ianevski, Philipp, Yadav, Bhagwan, Wennerberg, Krister, Aittokallio, Tero, Kallioniemi, Olli, Saarela, Jani, Östling, Päivi

“…Abstract Summary High-throughput screening (HTS) enables systematic testing of thousands of chemical compounds for potential use as investigational and…”
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Prediction model for drug response of acute myeloid leukemia patients by Trac, Quang Thinh, Pawitan, Yudi, Mou, Tian, Erkers, Tom, Östling, Päivi, Bohlin, Anna, Österroos, Albin, Vesterlund, Mattias, Jafari, Rozbeh, Siavelis, Ioannis, Bäckvall, Helena, Kiviluoto, Santeri, Orre, Lukas M., Rantalainen, Mattias, Lehtiö, Janne, Lehmann, Sören, Kallioniemi, Olli, Vu, Trung Nghia

“…Despite some encouraging successes, predicting the therapy response of acute myeloid leukemia (AML) patients remains highly challenging due to tumor…”
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ALDH1A1‐related stemness in high‐grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR‐PI3K/aurora kinase inhibitors by Kaipio, Katja, Chen, Ping, Roering, Pia, Huhtinen, Kaisa, Mikkonen, Piia, Östling, Päivi, Lehtinen, Laura, Mansuri, Naziha, Korpela, Taina, Potdar, Swapnil, Hynninen, Johanna, Auranen, Annika, Grénman, Seija, Wennerberg, Krister, Hautaniemi, Sampsa, Carpén, Olli

“…Poor chemotherapy response remains a major treatment challenge for high‐grade serous ovarian cancer (HGSC). Cancer stem cells are the major contributors to…”
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Consistency in drug response profiling by Mpindi, John Patrick, Yadav, Bhagwan, Östling, Päivi, Gautam, Prson, Malani, Disha, Murumägi, Astrid, Hirasawa, Akira, Kangaspeska, Sara, Wennerberg, Krister, Kallioniemi, Olli, Aittokallio, Tero

“…The comparative analysis by Haibe-Kains et al.1 concluded that data from two large-scale studies of cancer cell lines2,3 showed highly discordant results for…”
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