$Optimizing periprosthetic fracture management and in-hospital outcome: insights from the PIPPAS multicentric study of 1387 cases in Spain$
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Optimizing periprosthetic fracture management and in-hospital outcome: insights from the PIPPAS multicentric study of 1387 cases in Spain

Background The incidence of all periprosthetic fractures (PPF), which require complex surgical treatment associated with high morbidity and mortality, is predicted to increase. The evolving surgical management has created a knowledge gap regarding its impact on immediate outcomes. This study aimed t...

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Bibliographic Details
Published in:	Journal of orthopaedics and traumatology Vol. 25; no. 1; p. 13
Main Authors:	Aguado, Héctor J., Castillón-Bernal, Pablo, Teixidor-Serra, Jordi, García-Sánchez, Yaiza, Muñoz-Vives, Josep M., Camacho-Carrasco, Pilar, Jornet-Gibert, Montsant, Ojeda-Thies, Cristina, García-Portabella, Pablo, Pereda-Manso, Adela, Mateos-Álvarez, Elvira, Manzano-Mozo, Javier, Carrillo-Gómez, Raquel, País-Ortega, Sergio, García-Virto, Virginia, Noriega-González, David, Álvarez-Ramos, Begoña Aránzazu, Ganso-Pérez, Abel, Cervera-Díaz, Carmen, Plata-García, María, Ortega-Briones, Alina, Berrocal-Cuadrado, Juan, Criado del Rey-Machimbarrena, Diego, Salvador, Jordi, Rey, Laura, Tomás-Hernández, Jordi, Selga-Marsà, Jordi, Andrés-Peiró, José Vicente, Querolt-Coll, Jordi, Triana, Guillermo, Vives-Barquiel, Marian, Renau-Cerrillo, Marina, Campuzano-Bitterling, Borja, Hernández, José M, Ostilla, Ricardo, Carreras-Castañer, Anna, Torner, Pere, Díaz-Suárez, Rebeca, Fernández, Eliam Ajuria, Olaya-González, Carlos, Fernández-Villán, María, García de Cortázar, Unai, Arrieta, Mirentxu, Escobar, Daniel, Castrillo, Estíbaliz, Balvis, Patricia, Rodríguez-Arenas, Mónica, García-Pérez, Ángela, Moreta, Jesús, Bidea, Iñigo, Jiménez-Urrutia, Xabier, Olías-López, Beatriz, Boluda-Mengod, Juan, González-Martín, David, Bárcena-Goitiandia, Leopoldo, López-Dorado, Daniel, Borrás-Cebrián, Juan Carlos, García-Aguilera, David, Freile-Pazmiño, Patricio Andrés, Suárez-Suárez, Miguel Ángel, Lanuza-Lagunilla, Lucía, García-Arias, Antonio, Sánchez-Saz, Jaime, García-Coiradas, Javier, Valle-Cruz, José, Mora-Fernández, Jesús, Cano-Leira, María Ángeles, Rieiro, Guillermo, Benjumea-Carrasco, Antonio, Priego-Sánchez, Rodrigo Jesús, Sánchez-Pérez, Coral, Guadilla-Arsuaga, Jorge, Fernández-Juan, Alexis, Sánchez, Plácido, Ricón, Javier, Fuentes-Díaz, Alfonso, García-García, Elena M., Cuadrado-Abajo, Francisco, García-Portal, Gonzalo, del PozoManrique, Pedro, Castillo del Pozo, Virginia, Garcia-Navas, Francisco Manuel, García-Paredero, Ester, Beteta-Robles, Teresa, Guijarro-Valtueña, Ainhoa, Gutiérrez-Baiget, Gonzalo, Alonso-García, Noelia, Navas-Pernía, Inés, Ariza-Herrera, Diana, Vilanova, Joan, Videla-Cés, Miquel, Serra-Porta, Teresa, Vázquez-García, César, Carrasco-Becerra, Carmen, Pena-Paz, Silvia, Otero-Naveiro, Víctor, Fernández-Billón-Castrillo, Inés, Martínez-Menduiña, Amaia, Hernández-Galera, Carolina, Fernández-Dorado, Fátima
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 07-03-2024 Springer Nature B.V SpringerOpen
Subjects:	Aged Aged, 80 and over Ankle Arthroplasty Biomedical materials Cognitive ability Comorbidity Conservative Orthopedics Constrictions Disease management Elbow Elbow (anatomy) Epidemiology Femoral components Femur Fracture fixation Fractures Frailty Geriatric co-management Hip Hospitals Humans Joint surgery Knee Medicine Medicine & Public Health Morbidity Mortality NCT NCT04663893 Observational studies Original Article Orthopedics Outcome Patients Periprosthetic fracture Periprosthetic Fractures - epidemiology Periprosthetic Fractures - etiology Periprosthetic Fractures - surgery Prospective Studies Prostheses Regression models Replacement Revisions Rheumatology Spain - epidemiology Sports Medicine Statistical analysis Surgical Orthopedics Survival analysis Traumatic Surgery Weight Spain Periprosthetic fracture Outcome Mortality Fracture fixation Frailty Replacement Management Geriatric co-management Epidemiology Incidence
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Summary:	Background The incidence of all periprosthetic fractures (PPF), which require complex surgical treatment associated with high morbidity and mortality, is predicted to increase. The evolving surgical management has created a knowledge gap regarding its impact on immediate outcomes. This study aimed to describe current management strategies for PPF and their repercussions for in-hospital outcomes as well as to evaluate their implications for the community. Methods PIPPAS (Peri-Implant PeriProsthetic Survival Analysis) was a prospective multicentre observational study of 1387 PPF performed during 2021. Descriptive statistics summarized the epidemiology, fracture characteristics, management, and immediate outcomes. A mixed-effects logistic regression model was employed to evaluate potential predictors of in-hospital mortality, complications, discharge status, and weight-bearing restrictions. Results The study encompassed 32 (2.3%) shoulder, 4 (0.3%) elbow, 751 (54.1%) hip, 590 (42.5%) knee, and 10 (0.7%) ankle PPF. Patients were older (median 84 years, IQR 77–89), frail [median clinical frailty scale (CFS) 5, IQR 3–6], presented at least one comorbidity [median Charlson comorbidity index (CCI) 5, IQR 4–7], were community dwelling (81.8%), and had outdoor ambulation ability (65.6%). Femoral knee PPF were most frequently associated with uncemented femoral components, while femoral hip PPF occurred equally in cemented and uncemented stems. Patients were managed surgically (82%), with co-management (73.9%), through open approaches (85.9%) after almost 4 days (IQR, 51.9–153.6 h), with prosthesis revision performed in 33.8% of femoral hip PPF and 6.5% of femoral knee PPF. For half of the patients, the discharge instructions mandated weight-bearing restrictions. In-hospital mortality rates were 5.2% for all PPF and 6.2% for femoral hip PPF. Frailty, age > 84 years, mild cognitive impairment, CFS > 3, CCI > 3, and non-geriatric involvement were candidate predictors for in-hospital mortality, medical complications, and discharge to a nursing care facility. Management involving revision arthroplasty by experienced surgeons favoured full weight-bearing, while an open surgical approach favoured weight-bearing restrictions. Conclusions Current arthroplasty fixation check and revision rates deviate from established guidelines, yet full weight-bearing is favoured. A surgical delay of over 100 h and a lack of geriatric co-management were related to in-hospital mortality and medical complications. This study recommends judicious hypoaggressive approaches. Addressing complications and individualizing the surgical strategy can lead to enhanced functional outcomes, alleviating the economic and social burdens upon hospital discharge. Level of Evidence Level IV case series. Trial registration : registered at ClinicalTrials.gov (NCT04663893), protocol ID: PI 20-2041. Graphical abstract
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1590-9999 1590-9921 1590-9999
DOI:	10.1186/s10195-024-00746-6