Search Results - "Osterreicher, Christoph H"

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth by Grivennikov, Sergei I., Wang, Kepeng, Mucida, Daniel, Stewart, C. Andrew, Schnabl, Bernd, Jauch, Dominik, Taniguchi, Koji, Yu, Guann-Yi, Österreicher, Christoph H., Hung, Kenneth E., Datz, Christian, Feng, Ying, Fearon, Eric R., Oukka, Mohamed, Tessarollo, Lino, Coppola, Vincenzo, Yarovinsky, Felix, Cheroutre, Hilde, Eckmann, Lars, Trinchieri, Giorgio, Karin, Michael

“…In a mouse model of colorectal cancer, barrier deterioration results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which…”
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Hepatocytes do not undergo epithelial‐mesenchymal transition in liver fibrosis in mice by Taura, Kojiro, Miura, Kouichi, Iwaisako, Keiko, Österreicher, Christoph H., Kodama, Yuzo, Penz‐Österreicher, Melitta, Brenner, David A.

“…The origin of fibrogenic cells in liver fibrosis remains controversial. We assessed the emerging concept that hepatocytes contribute to production of…”
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Genomics of liver fibrosis and cirrhosis by Osterreicher, Christoph H, Stickel, Felix, Brenner, David A

“…Hepatic fibrosis is the response to chronic injury from viral, toxic, metabolic, cholestatic, or autoimmune liver injury. However, only a minority of affected…”
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TLR4 enhances TGF-β signaling and hepatic fibrosis by Seki, Ekihiro, De Minicis, Samuele, Brenner, David A, Osawa, Yosuke, Schwabe, Robert F, Österreicher, Christoph H, Kluwe, Johannes

“…Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products. Here we report that the intestinal…”
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Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression by Park, Eek Joong, Lee, Jun Hee, Yu, Guann-Yi, He, Guobin, Ali, Syed Raza, Holzer, Ryan G., Österreicher, Christoph H., Takahashi, Hiroyuki, Karin, Michael

“…Epidemiological studies indicate that overweight and obesity are associated with increased cancer risk. To study how obesity augments cancer risk and…”
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Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice by Meng, Fanli, Wang, Kai, Aoyama, Tomonori, Grivennikov, Sergei I, Paik, YongHan, Scholten, David, Cong, Min, Iwaisako, Keiko, Liu, Xiao, Zhang, Mingjun, Österreicher, Christoph H, Stickel, Felix, Ley, Klaus, Brenner, David A, Kisseleva, Tatiana

“…Background & Aims Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis. We examined the role of IL-17 signaling in the pathogenesis of…”
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Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice by Scholten, David, Österreicher, Christoph H, Scholten, Anjali, Iwaisako, Keiko, Gu, Guoqiang, Brenner, David A, Kisseleva, Tatiana

“…Background & Aims Chronic injury changes the fate of certain cellular populations, inducing epithelial cells to generate fibroblasts by…”
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Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition by Kluwe, Johannes, Pradere, Jean–Philippe, Gwak, Geum–Youn, Mencin, Ali, De Minicis, Samuele, Österreicher, Christoph H, Colmenero, Jordi, Bataller, Ramon, Schwabe, Robert F

“…Background & Aims c-Jun N-terminal kinase (JNK) is activated by multiple profibrogenic mediators; JNK activation occurs during toxic, metabolic, and autoimmune…”
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c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice by Kodama, Yuzo, Kisseleva, Tatiana, Iwaisako, Keiko, Miura, Kouichi, Taura, Kojiro, De Minicis, Samuele, Österreicher, Christoph H, Schnabl, Bernd, Seki, Ekihiro, Brenner, David A

“…Background & Aims c-Jun N-terminal kinase (JNK) plays a pivotal role in the development of the metabolic syndrome including nonalcoholic fatty liver disease…”
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Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis by Inokuchi, Sayaka, Aoyama, Tomonori, Miura, Kouichi, Österreicher, Christoph H, Kodama, Yuzo, Miyai, Katsumi, Akira, Shizuo, Brenner, David A, Seki, Ekihiro

“…TGF-β-activated kinase 1 (TAK1) is a MAP3K family member that activates NF-κB and JNK via Toll-like receptors and the receptors for IL-1, TNF-α, and TGF-β…”
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Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis by Taura, Kojiro, De Minicis, Samuele, Seki, Ekihiro, Hatano, Etsuro, Iwaisako, Keiko, Osterreicher, Christoph H, Kodama, Yuzo, Miura, Kouichi, Ikai, Iwao, Uemoto, Shinji, Brenner, David A

“…Background & Aims Although angiogenesis is closely associated with liver fibrosis, the angiogenic factors involved in liver fibrosis are not well…”
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The genetics of nonalcoholic fatty liver disease by Osterreicher, Christoph H, Brenner, David A

“…The increasing prevalence of obesity in Western countries has led to a significant increase of nonalcoholic fatty liver disease (NAFLD) over the past decades…”
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Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis by Baghdasaryan, Anna, Fuchs, Claudia D, Österreicher, Christoph H, Lemberger, Ursula J, Halilbasic, Emina, Påhlman, Ingrid, Graffner, Hans, Krones, Elisabeth, Fickert, Peter, Wahlström, Annika, Ståhlman, Marcus, Paumgartner, Gustav, Marschall, Hanns-Ulrich, Trauner, Michael

“…Graphical abstract…”
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Resolution of liver fibrosis requires myeloid cell–driven sinusoidal angiogenesis by Kantari‐Mimoun, Chahrazade, Castells, Magali, Klose, Ralph, Meinecke, Anna‐Katharina, Lemberger, Ursula J., Rautou, Pierre‐Emmanuel, Pinot‐Roussel, Hélène, Badoual, Cécile, Schrödter, Katrin, Österreicher, Christoph H., Fandrey, Joachim, Stockmann, Christian

“…Angiogenesis is a key feature of liver fibrosis. Although sinusoidal remodeling is believed to contribute to fibrogenesis, the impact of sinusoidal…”
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Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver by Österreicher, Christoph H, Penz-Österreicher, Melitta, Grivennikov, Sergei I, Guma, Monica, Koltsova, Ekaterina K, Datz, Christian, Sasik, Roman, Hardiman, Gary, Karin, Michael, Brenner, David A

“…Cirrhosis is the end result of chronic liver disease. Hepatic stellate cells (HSC) are believed to be the major source of collagen-producing myofibroblasts in…”
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24- nor -ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis by Sombetzki, Martina, Fuchs, Claudia D, Fickert, Peter, Österreicher, Christoph H, Mueller, Michaela, Claudel, Thierry, Loebermann, Micha, Engelmann, Robby, Langner, Cord, Sahin, Emine, Schwinge, Dorothee, Guenther, Nina D, Schramm, Christoph, Mueller-Hilke, Brigitte, Reisinger, Emil C, Trauner, Michael

“…Graphical abstract…”
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Angiotensin‐converting‐enzyme 2 inhibits liver fibrosis in mice by Österreicher, Christoph H., Taura, Kojiro, De Minicis, Samuele, Seki, Ekihiro, Penz‐Österreicher, Melitta, Kodama, Yuzo, Kluwe, Johannes, Schuster, Manfred, Oudit, Gavin Y., Penninger, Josef M., Brenner, David A.

“…The renin‐angiotensin system (RAS) plays a major role in liver fibrosis. Recently, a homolog of angiotensin‐converting‐enzyme 1 (ACE1), termed ACE2, has been…”
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Genetic polymorphisms of manganese-superoxide dismutase and glutathione-S-transferase in chronic alcoholic pancreatitis by Österreicher, Christoph H., Schultheiss, Jürgen, Wehler, Markus, Homann, Nils, Hellerbrand, Claus, Künzli, Beat, Friess, Helmut, Seitz, Helmut K., Stickel, Felix

“…Chronic alcohol consumption is a major risk factor for the development of chronic pancreatitis. However, chronic pancreatitis occurs only in a minority of…”
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Fibrosis in Autoimmune and Cholestatic Liver Disease by Penz-Österreicher, Melitta, M.D, Österreicher, Christoph H., M.D, Trauner, Michael, M.D

“…Autoimmune and cholestatic liver disease account for a significant part of end-stage liver disease and are leading indications for liver transplantation…”
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Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis by De Minicis, Samuele, Seki, Ekihiro, Paik, Yong‐Han, Österreicher, Christoph H., Kodama, Yuzo, Kluwe, Johannes, Torozzi, Luciano, Miyai, Katsumi, Benedetti, Antonio, Schwabe, Robert F., Brenner, David A.

“…Reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate oxidase (NOX) is required for liver fibrosis. This study investigates…”
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