Search Results - "Ostermaier, K"

Functional map of arrestin-1 at single amino acid resolution by Ostermaier, Martin K., Peterhans, Christian, Jaussi, Rolf, Deupi, Xavier, Standfuss, Jörg

“…Arrestins function as adapter proteins that mediate G protein-coupled receptor (GPCR) desensitization, internalization, and additional rounds of signaling…”
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RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle by Albert, Benjamin, Léger-Silvestre, Isabelle, Normand, Christophe, Ostermaier, Martin K, Pérez-Fernández, Jorge, Panov, Kostya I, Zomerdijk, Joost C.B.M, Schultz, Patrick, Gadal, Olivier

“…RNA polymerase I (Pol I) produces large ribosomal RNAs (rRNAs). In this study, we show that the Rpa49 and Rpa34 Pol I subunits, which do not have counterparts…”
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AAscan, PCRdesign and MutantChecker: a suite of programs for primer design and sequence analysis for high-throughput scanning mutagenesis by Sun, Dawei, Ostermaier, Martin K, Heydenreich, Franziska M, Mayer, Daniel, Jaussi, Rolf, Standfuss, Joerg, Veprintsev, Dmitry B

“…Scanning mutagenesis is a powerful protein engineering technique used to study protein structure-function relationship, map binding sites and design more…”
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Immunodeficiency in Down Syndrome: Revisiting Recurrent Infections in the Post-Pneumococcal Vaccination Era by Ram, G, Ostermaier, K, Hanson, I.C, Chinen, J

“…Frequency of RI was significantly associated with history of allergic rhinitis/asthma (odds ratio [OR]:15.8 [95% confidence interval [CI]:4.3-58.5]), GERD…”
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A Road Map for Academic Developmental-Behavioral Pediatric Practices to Increase Access by Godwin, Dinah L., Cervantes, Jennifer, Torres, Jennifer Y., Ostermaier, Kathryn K., Berry, Leandra N., Voigt, Robert G.

“…There are currently at least 19 million children and adolescents in the United States with disorders of development (learning disorders,…”
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Incidence of Celiac Disease in Down Syndrome: A Longitudinal, Population-Based Birth Cohort Study by Ostermaier, Kathryn K., Weaver, Amy L., Myers, Scott M., Stoeckel, Ruth E., Katusic, Slavica K., Voigt, Robert G.

“…American Academy of Pediatrics (AAP) guidelines for children with Down syndrome (DS) include assessment for celiac disease (CD), although data to support this…”
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Insights into congenital stationary night blindness based on the structure of G90D rhodopsin by Singhal, Ankita, Ostermaier, Martin K, Vishnivetskiy, Sergey A, Panneels, Valérie, Homan, Kristoff T, Tesmer, John J G, Veprintsev, Dmitry, Deupi, Xavier, Gurevich, Vsevolod V, Schertler, Gebhard F X, Standfuss, Joerg

“…We present active‐state structures of the G protein‐coupled receptor (GPCRs) rhodopsin carrying the disease‐causing mutation G90D. Mutations of G90 cause…”
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Immobilization of arrestin-3 on different biosensor platforms for evaluating GPCR binding by Avsar, Saziye Yorulmaz, Kapinos, Larisa E, Schoenenberger, Cora-Ann, Schertler, Gebhard F X, Mühle, Jonas, Meger, Benoit, Lim, Roderick Y H, Ostermaier, Martin K, Lesca, Elena, Palivan, Cornelia G

“…G protein-coupled receptors (GPCRs) are a large and ubiquitous family of membrane receptors of great pharmacological interest. Cell-based assays are the…”
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Functional map of arrestin binding to phosphorylated opsin, with and without agonist by Peterhans, Christian, Lally, Ciara C. M., Ostermaier, Martin K., Sommer, Martha E., Standfuss, Jörg

“…Arrestins desensitize G protein-coupled receptors (GPCRs) and act as mediators of signalling. Here we investigated the interactions of arrestin-1 with two…”
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Molecular mechanism of phosphorylation-dependent arrestin activation by Ostermaier, Martin K, Schertler, Gebhard FX, Standfuss, Joerg

“…•Novel structures provide insight into the arrestin activation mechanism.•Arrestins are pre-activated by a C-tail exchange mechanism.•Functional data for…”
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Arrestin-1 engineering facilitates complex stabilization with native rhodopsin by Haider, Raphael S., Wilhelm, Florian, Rizk, Aurélien, Mutt, Eshita, Deupi, Xavier, Peterhans, Christian, Mühle, Jonas, Berger, Philipp, Schertler, Gebhard F. X., Standfuss, Jörg, Ostermaier, Martin K.

“…Arrestin-1 desensitizes the activated and phosphorylated photoreceptor rhodopsin by forming transient rhodopsin−arrestin-1 complexes that eventually decay to…”
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Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding by Vishnivetskiy, Sergey. A., Ostermaier, Martin K., Singhal, Ankita, Panneels, Valerie, Homan, Kristoff T., Glukhova, Alisa, Sligar, Stephen G., Tesmer, John J.G., Schertler, Gebhard F.X., Standfuss, Joerg, Gurevich, Vsevolod V.

“…The effects of activating mutations associated with night blindness on the stoichiometry of rhodopsin interactions with G protein-coupled receptor kinase 1…”
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Teaching Pediatric Residents to Assess for Autism Spectrum Disorders by Monteiro, Sonia A., MD, Ostermaier, Kathryn K., MD, Godwin, Dinah, MSW, Voigt, Robert, MD

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Association of copper-zinc superoxide dismutase (SOD1) and manganese superoxide dismutase (SOD2) genes with nonsyndromic myelomeningocele by Kase, Benjamin A., Northrup, Hope, Morrison, Alanna C., Davidson, Christina M., Goiffon, Amanda M., Fletcher, Jack M., Ostermaier, Kathryn K., Tyerman, Gayle H., Au, Kit Sing

“…BACKGROUND A common and severe neural tube defect (NTD) phenotype, myelomeningocele (MM), results from the defective closure of the caudal end of the neural…”
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Association of folate receptor (folr1, folr2, folr3) and reduced folate carrier (slc19a1) genes with meningomyelocele by O'Byrne, Michelle R., Au, Kit Sing, Morrison, Alanna C., Lin, Jone-Ing, Fletcher, Jack M., Ostermaier, Kathryn K., Tyerman, Gayle H., Doebel, Sabine, Northrup, Hope

“…Background Meningomyelocele (MM) results from lack of closure of the neural tube during embryologic development. Periconceptional folic acid supplementation is…”
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Corrigendum: Functional map of arrestin binding to phosphorylated opsin, with and without agonist by Peterhans, Christian, Lally, Ciara C M, Ostermaier, Martin K, Sommer, Martha E, Standfuss, Jörg

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Association of retinoic acid receptor genes with meningomyelocele by Tran, Phong X., Au, Kit Sing, Morrison, Alanna C., Fletcher, Jack M., Ostermaier, Kathryn K., Tyerman, Gayle H., Northrup, Hope

“…BACKGROUND Neural tube defects (NTDs) occur in as many as 0.5–2 per 1000 live births in the United States. One of the most common and severe neural tube…”
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Characteristics of a spina bifida population including North American Caucasian and Hispanic individuals by Au, Kit Sing, Tran, Phong X., Tsai, Chester C., O'Byrne, Michelle R., Lin, Jone-Ing, Morrison, Alanna C., Hampson, Amy W., Cirino, Paul, Fletcher, Jack M., Ostermaier, Kathryn K., Tyerman, Gayle H., Doebel, Sabine, Northrup, Hope

“…BACKGROUND: Meningomyelocele (MM) is a common human birth defect. MM is a disorder of neural development caused by contributions from genes and environmental…”
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A Road Map for Academic Developmental-Behavioral Pediatric Practices to Increase Access by Godwin, Dinah L., Cervantes, Jennifer, Torres, Jennifer Y., Ostermaier, Kathryn K., Berry, Leandra N., Voigt, Robert G.

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Correction: Corrigendum: Functional map of arrestin binding to phosphorylated opsin, with and without agonist by Peterhans, Christian, Lally, Ciara C. M., Ostermaier, Martin K., Sommer, Martha E., Standfuss, Jörg

“…Scientific Reports 6: Article number: 28686; published online: 28 June 2016; updated: 22 July 2016 In this Article, Martin K. Ostermaier is incorrectly listed…”
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