Search Results - "Osterloh, Jeannette M"
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dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
Published in Science (American Association for the Advancement of Science) (27-07-2012)“…Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to…”
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Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly
Published in Neuron (Cambridge, Mass.) (05-07-2017)“…Axon degeneration is a hallmark of neurodegenerative disease and neural injury. Axotomy activates an intrinsic pro-degenerative axon death signaling cascade…”
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Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy
Published in Cell (21-01-2021)“…The December 2019 outbreak of a novel respiratory virus, SARS-CoV-2, has become an ongoing global pandemic due in part to the challenge of identifying…”
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Manipulating cell fate while confronting reproducibility concerns
Published in Biochemical pharmacology (01-05-2018)“…[Display omitted] Biomedical research is being transformed by the discovery and use of human pluripotent stem cells (hPSCs). Remarkable progress has been made,…”
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Neuronal death or dismemberment mediated by Sox14
Published in Nature neuroscience (01-12-2009)“…The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis,…”
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Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis
Published in Human molecular genetics (01-11-2018)“…Axon degeneration occurs in all neurodegenerative diseases, but the molecular pathways regulating axon destruction during neurodegeneration are poorly…”
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