Search Results - "Osterloh, Jeannette"
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Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy
Published in Cell (21-01-2021)“…The December 2019 outbreak of a novel respiratory virus, SARS-CoV-2, has become an ongoing global pandemic due in part to the challenge of identifying…”
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dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
Published in Science (American Association for the Advancement of Science) (27-07-2012)“…Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to…”
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Manipulating cell fate while confronting reproducibility concerns
Published in Biochemical pharmacology (01-05-2018)“…[Display omitted] Biomedical research is being transformed by the discovery and use of human pluripotent stem cells (hPSCs). Remarkable progress has been made,…”
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Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly
Published in Neuron (Cambridge, Mass.) (05-07-2017)“…Axon degeneration is a hallmark of neurodegenerative disease and neural injury. Axotomy activates an intrinsic pro-degenerative axon death signaling cascade…”
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Neuronal death or dismemberment mediated by Sox14
Published in Nature neuroscience (01-12-2009)“…The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis,…”
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Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens
Published in Biology (Basel, Switzerland) (05-12-2012)“…Forward genetic screens in Drosophila melanogaster using ethyl methanesulfonate (EMS) mutagenesis are a powerful approach for identifying genes that modulate…”
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Results of Single-Arm, Phase 1b Study of Anti-C1q Treatment (ANX009) Show that the Classical Pathway Is a Key Driver of Complement Activation and Consumption in Patients with Active Lupus Nephritis: SA-PO878
Published in Journal of the American Society of Nephrology (01-11-2023)Get full text
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Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis
Published in Human molecular genetics (01-11-2018)“…Axon degeneration occurs in all neurodegenerative diseases, but the molecular pathways regulating axon destruction during neurodegeneration are poorly…”
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Formation of a Bioactive Layer on a Conductive Polymer
Published in The FASEB journal (01-03-2006)“…Phage display panning techniques were used to isolate peptides that bind specifically to the polymer Poly [2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylenevinylene]…”
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