Search Results - "Ostergaard, A"

The Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease by Tan, Sih Min, Snelson, Matthew, Østergaard, Jakob A, Coughlan, Melinda T

“…The metabolic disorder, diabetes mellitus, results in microvascular complications, including diabetic kidney disease (DKD), which is partly believe to involve…”
Get more information

Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease by Østergaard, Jakob A, Jha, Jay C, Sharma, Arpeeta, Dai, Aozhi, Choi, Judy S Y, de Haan, Judy B, Cooper, Mark E, Jandeleit-Dahm, Karin

“…Activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome has been reported in diabetic…”
Get more information

Mannan-Binding Lectin Is Associated with Inflammation and Kidney Damage in a Mouse Model of Type 2 Diabetes by Dørflinger, Gry H, Holt, Charlotte B, Thiel, Steffen, Bech, Jesper N, Østergaard, Jakob A, Bjerre, Mette

“…Autoreactivity of the complement system may escalate the development of diabetic nephropathy. We used the BTBR OB mouse model of type 2 diabetes to investigate…”
Get full text

High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-(13)C]pyruvate magnetic resonance imaging by Laustsen, Christoffer, Lycke, Sara, Palm, Fredrik, Østergaard, Jakob A, Bibby, Bo M, Nørregaard, Rikke, Flyvbjerg, Allan, Pedersen, Michael, Ardenkjaer-Larsen, Jan H

“…The kidneys account for about 10% of the whole body oxygen consumption, whereas only 0.5% of the total body mass. It is known that intrarenal hypoxia is…”
Get more information

Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy by Jepsen, Malene R., Østergaard, Jakob A., Conover, Cheryl A., Wogensen, Lise, Birn, Henrik, Krag, Søren P., Fenton, Robert A., Oxvig, Claus

“…Diabetic nephropathy (DN) is a serious complication of diabetes and a common cause of end stage renal failure. Insulin-like growth factor (IGF)-signaling has…”
Get full text

Geographic aggregation and wind power output variance in Denmark by OSTERGAARD, Poul A

“…At modest penetration, wind power merely substitutes electricity generated typically at thermal power plants. In this case, wind power only provides economic…”
Get full text

Treatment of Type 2 Diabetes With GLP-1 Receptor Agonists Among Patients With CKD by Østergaard, Jakob A., Cooper, Mark E.

Get full text

Effect of dipeptidyl peptidase‐4 inhibitors on complement activation by Hoffmann‐Petersen, Ingeborg T., Holt, Charlotte B., Jensen, Lisbeth, Hage, Camilla, Mellbin, Linda G., Thiel, Steffen, Hansen, Troels K., Østergaard, Jakob A.

“…Background Adverse activation of the complement cascade in the innate immune system appears to be involved in development of vascular complications in…”
Get full text

The Discordance Between the Renal Histopathology and Clinical Presentation of Diabetic Nephropathy Calls for Novel Approaches for the Prediction and Monitoring of Kidney Failure in Diabetes by Østergaard, Jakob A., Cooper, Mark E.

Get full text

Increased all-cause mortality in patients with type 1 diabetes and high-expression mannan-binding lectin genotypes: a 12-year follow-up study by Østergaard, Jakob A, Thiel, Steffen, Lajer, Maria, Steffensen, Rudi, Parving, Hans-Henrik, Flyvbjerg, Allan, Rossing, Peter, Tarnow, Lise, Hansen, Troels K

“…Mannan-binding lectin (MBL) is a complement-activating carbohydrate-recognizing molecule associated with diabetic nephropathy. MBL is associated with all-cause…”
Get full text

Association of the pattern recognition molecule H-ficolin with incident microalbuminuria in an inception cohort of newly diagnosed type 1 diabetic patients: an 18 year follow-up study by Østergaard, Jakob A., Thiel, Steffen, Hovind, Peter, Holt, Charlotte B., Parving, Hans-Henrik, Flyvbjerg, Allan, Rossing, Peter, Hansen, Troels K.

“…Aims/hypothesis Increasing evidence links complement activation through the lectin pathway to diabetic nephropathy. Adverse complement recognition of proteins…”
Get full text

Heat Roadmap Europe: Combining district heating with heat savings to decarbonise the EU energy system by Connolly, D., Lund, H., Mathiesen, B.V., Werner, S., Möller, B., Persson, U., Boermans, T., Trier, D., Østergaard, P.A., Nielsen, S.

“…Six different strategies have recently been proposed for the European Union (EU) energy system in the European Commission's report, Energy Roadmap 2050. The…”
Get full text

Mg(2+) binding to the Gla domain of factor X influences the interaction with tissue factor by Persson, E, Ostergaard, A

Get full text

Diabetes‐induced Changes in Mannan‐binding Lectin Levels and Complement Activation in a Mouse Model of Type 1 Diabetes by Østergaard, J. A., Bjerre, M., Dagnæs‐Hansen, F., Hansen, T. K., Thiel, S., Flyvbjerg, A.

“…Circulating mannan‐binding lectin (MBL) levels are elevated in type 1 diabetes. Further, high MBL levels are associated with the development of diabetic…”
Get full text

Latent autoimmune diabetes of the adult: current knowledge and uncertainty by Laugesen, E., Østergaard, J. A., Leslie, R. D. G.

“…Patients with adult‐onset autoimmune diabetes have less Human Leucocyte Antigen (HLA)‐associated genetic risk and fewer diabetes‐associated autoantibodies…”
Get full text

Sentinel-1 antenna model validation: Pattern prediction vs. PNFS measurements by Hees, A., Koch, P., Rostan, F., Huchler, M., Croci, R., Østergaard, A.

“…The C-SAR Antenna Subsystem (SAS) of the European Radar Observatory Sentinel-1 is comprised of an active dual-polarized phased array consisting of 280…”
Get full text

Association between endogenous complement inhibitor and myocardial salvage in patients with myocardial infarction by Holt, Charlotte B, Thiel, Steffen, Munk, Kim, Østergaard, Jakob A, Bøtker, Hans E, Hansen, Troels K

“…Background: Many pathogenic processes and diseases are the result of an erroneous activation of the complement cascade and a number of inhibitors of complement…”
Get full text

Fatal 3-Nitropropionic Acid Poisoning after Consuming Coconut Water by Birkelund, Thomas, Johansen, Rakel F, Illum, Dorte G, Dyrskog, Stig Eric, Østergaard, Jakob A, Falconer, Travis M, Andersen, Chris, Fridholm, Helena, Overballe-Petersen, Søren, Jensen, Jørgen S

“…We describe the fatal course of a patient with initial symptoms of vomiting and nausea who developed symptoms of dystonia, encephalopathy, and coma. The cause…”
Get full text

Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways by Jha, Jay C, Dai, Aozhi, Garzarella, Jessica, Charlton, Amelia, Urner, Sofia, Østergaard, Jakob A, Okabe, Jun, Holterman, Chet E, Skene, Alison, Power, David A, Ekinci, Elif I, Coughlan, Melinda T, Schmidt, Harald H H W, Cooper, Mark E, Touyz, Rhian M, Kennedy, Chris R, Jandeleit-Dahm, Karin

“…Excessive production of renal reactive oxygen species (ROS) plays a major role in diabetic kidney disease (DKD). Here, we provide key findings demonstrating…”
Get full text

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes by Brouwers, Olaf, Niessen, Petra M. G., Miyata, Toshio, Østergaard, Jakob A., Flyvbjerg, Allan, Peutz-Kootstra, Carine J., Sieber, Jonas, Mundel, Peter H., Brownlee, Michael, Janssen, Ben J. A., De Mey, Jo G. R., Stehouwer, Coen D. A., Schalkwijk, Casper G.

“…Aims/hypothesis In diabetes, advanced glycation end-products (AGEs) and the AGE precursor methylglyoxal (MGO) are associated with endothelial dysfunction and…”
Get full text