Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review

Background. Systemic sclerosis (SSc) is a chronic multisystem autoimmune condition defined by a complex pathobiology, comprising excessive fibrosis of skin and internal organs, peripheral vasculopathy with endothelial cell dysfunction, inadequate vascular repair and neovascularization, and aberrant...

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Published in:	Journal of immunology research Vol. 2021; pp. 9782994 - 15
Main Authors:	Diaconu, Alexandra-Diana, Ostafie, Iustina, Ceasovschih, Alexandr, Șorodoc, Victorița, Lionte, Cătălina, Ancuța, Codrina, Șorodoc, Laurențiu
Format:	Journal Article
Language:	English
Published:	Egypt Hindawi 29-11-2021 Hindawi Limited
Subjects:	Autoimmune diseases Bone turnover Calcium homeostasis Cytokines Dietary Supplements Endothelial cells Fibrosis Growth factors Homeostasis Humans Immunology Immunomodulation Kidneys Literature reviews Patients Pediatrics Phenotypes Review Scleroderma Scleroderma, Systemic - blood Scleroderma, Systemic - diagnosis Scleroderma, Systemic - diet therapy Scleroderma, Systemic - immunology Severity of Illness Index Skin Systematic review Systemic sclerosis Ulcers Vascular diseases Vascularization Vitamin D Vitamin D - administration & dosage Vitamin D - blood Vitamin D - immunology Vitamin D Deficiency - blood Vitamin D Deficiency - diagnosis Vitamin D Deficiency - immunology Vitamin deficiency
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Summary:	Background. Systemic sclerosis (SSc) is a chronic multisystem autoimmune condition defined by a complex pathobiology, comprising excessive fibrosis of skin and internal organs, peripheral vasculopathy with endothelial cell dysfunction, inadequate vascular repair and neovascularization, and aberrant immunity. Vitamin D is a steroid hormone with pleiotropic effects beyond its traditional role in calcium and bone homeostasis. Since vitamin D has immunomodulatory, cardioprotective, and antifibrotic properties, it could potentially interfere with SSc pathogenesis. Suboptimal vitamin D levels are classically recognized in scleroderma, irrespective of clinical and serological phenotype. Aim. This systematic review is aimed at investigating and clarifying the role of vitamin D in SSc and emphasizing the association of vitamin D status with different clinical settings. Methods and Results. A systematic online search was performed, using PubMed databases to collect articles on the topic of vitamin D in SSc. The final analysis included 40 eligible articles. Conclusions. Hypovitaminosis D is common in SSc patients and could be associated with clinical and serologic patterns of the disease. Intervention for low serum vitamin D levels in SSc pathogenesis remains controversial, as well as the significance of vitamin D supplementation in such patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Academic Editor: Vlad Padureanu
ISSN:	2314-8861 2314-7156
DOI:	10.1155/2021/9782994