Search Results - "Osta, Mike A."

The mosquito melanization response is implicated in defense against the entomopathogenic fungus Beauveria bassiana by Yassine, Hassan, Kamareddine, Layla, Osta, Mike A

“…Mosquito immunity studies have focused mainly on characterizing immune effector mechanisms elicited against parasites, bacteria and more recently, viruses…”
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The mosquito melanization response requires hierarchical activation of non-catalytic clip domain serine protease homologs by El Moussawi, Layla, Nakhleh, Johnny, Kamareddine, Layla, Osta, Mike A

“…Serine protease cascades regulate important insect immune responses namely melanization and Toll pathway activation. An important component of these cascades…”
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CLIPA7 Exhibits Pleiotropic Roles in the Anopheles gambiae Immune Response by Zakhia, Renée, Osta, Mike A.

“…Abstract Clip domain serine proteases and clip domain serine protease homologs (cSPHs) are key components of serine protease cascades that drive the…”
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Late sporogonic stages of Plasmodium parasites are susceptible to the melanization response in Anopheles gambiae mosquitoes by Zeineddine, Suheir, Jaber, Sana, Saab, Sally A, Nakhleh, Johnny, Dimopoulos, George, Osta, Mike A

“…The malaria-causing parasites have to complete a complex infection cycle in the mosquito vector that also involves attack by the insect's innate immune system,…”
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The Route of Infection Influences the Contribution of Key Immunity Genes to Antibacterial Defense in Anopheles gambiae by Dekmak, Amira San, Yang, Xiaowei, Zu Dohna, Heinrich, Buchon, Nicolas, Osta, Mike A.

“…Insect systemic immune responses to bacterial infections have been mainly studied using microinjections, whereby the microbe is directly injected into the…”
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The CLIP-domain serine protease homolog SPCLIP1 regulates complement recruitment to microbial surfaces in the malaria mosquito Anopheles gambiae by Povelones, Michael, Bhagavatula, Lavanya, Yassine, Hassan, Tan, Lee Aun, Upton, Leanna M, Osta, Mike A, Christophides, George K

“…The complement C3-like protein TEP1 of the mosquito Anopheles gambiae is required for defense against malaria parasites and bacteria. Two forms of TEP1 are…”
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CLIPB10 is a Terminal Protease in the Regulatory Network That Controls Melanization in the African Malaria Mosquito Anopheles gambiae by Zhang, Xin, Li, Miao, El Moussawi, Layla, Saab, Sally, Zhang, Shasha, Osta, Mike A, Michel, Kristin

“…Humoral immune responses in animals are often tightly controlled by regulated proteolysis. This proteolysis is exerted by extracellular protease cascades,…”
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CLIPB4 Is a Central Node in the Protease Network that Regulates Humoral Immunity in Anopheles gambiae Mosquitoes by Zhang, Xiufeng, Zhang, Shasha, Kuang, Junyao, Sellens, Kathleen A., Morejon, Bianca, Saab, Sally A., Li, Miao, Metto, Eve C., An, Chunju, Culbertson, Christopher T., Osta, Mike A., Scoglio, Caterina, Michel, Kristin

“…Abstract Insect humoral immune responses are regulated in part by protease cascades, whose components circulate as zymogens in the hemolymph. In mosquitoes,…”
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Two C-type Lectins Cooperate to Defend Anopheles gambiae against Gram-negative Bacteria by Schnitger, Anna K.D., Yassine, Hassan, Kafatos, Fotis C., Osta, Mike A.

“…C-type lectins (CTLs) are a family of proteins that share a common structural motif, the carbohydrate recognition domain, and may act as receptors in pathogen…”
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The Melanization Reaction Is Not Required for Survival of Anopheles gambiae Mosquitoes after Bacterial Infections by Schnitger, Anna K.D., Kafatos, Fotis C., Osta, Mike A.

“…The melanization reaction of insects requires activation of pro-phenoloxidase by a proteolytic cascade leading to melanin production. Studies in adult…”
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The Roles of Two Clip Domain Serine Proteases in Innate Immune Responses of the Malaria Vector Anopheles gambiae by Volz, Jennifer, Osta, Mike A., Kafatos, Fotis C., Müller, Hans-Michael

“…The malaria vector Anopheles gambiae is capable of multiple immune responses against Plasmodium ookinetes. Accumulating evidence in several insect species…”
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Expression of trypsin modulating oostatic factor (TMOF) in an entomopathogenic fungus increases its virulence towards Anopheles gambiae and reduces fecundity in the target mosquito by Kamareddine, Layla, Fan, Yanhua, Osta, Mike A, Keyhani, Nemat O

“…BACKGROUND: Adult and larval mosquitoes regulate food digestion in their gut with trypsin modulating oostatic factor (TMOF), a decapeptide hormone synthesized…”
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Insecticide resistance to organophosphates in Culex pipiens complex from Lebanon by Osta, Mike A, Rizk, Zeinab J, Labbé, Pierrick, Weill, Mylène, Knio, Khouzama

“…BACKGROUND: Analysis of Culex pipiens mosquitoes collected from a single site in Lebanon in 2005, revealed an alarming frequency of ace-1 alleles conferring…”
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Insight into the structural hierarchy of the protease cascade that regulates the mosquito melanization response by Saab, Sally A, Zhang, Xiufeng, Zeineddine, Suheir, Morejon, Bianca, Michel, Kristin, Osta, Mike A

“…Serine protease cascades regulate important insect immune responses, including melanization and Toll pathway activation. In the context of melanization,…”
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The serine protease homolog CLIPA14 modulates the intensity of the immune response in the mosquito Anopheles gambiae by Nakhleh, Johnny, Christophides, George K., Osta, Mike A.

“…Clip domain serine protease homologs (SPHs) are positive and negative regulators of Anopheles gambiae immune responses mediated by the complement-like protein…”
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Functional Interaction between Apolipophorins and Complement Regulate the Mosquito Immune Response to Systemic Infections by Kamareddine, Layla, Nakhleh, Johnny, Osta, Mike A.

“…The complement-like protein thioester-containing protein 1 (TEP1) is the hallmark effector molecule against Plasmodium ookinetes in the malaria vector…”
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The environment and species affect gut bacteria composition in laboratory co-cultured Anopheles gambiae and Aedes albopictus mosquitoes by Saab, Sally A., Dohna, Heinrich zu, Nilsson, Louise K. J., Onorati, Piero, Nakhleh, Johnny, Terenius, Olle, Osta, Mike A.

“…The midgut microbiota of disease vectors plays a critical role in the successful transmission of human pathogens. The environment influences the microbiota…”
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Anopheles gambiae innate immunity by Yassine, Hassan, Osta, Mike A.

“…Summary The successful development of Plasmodium in Anopheles mosquitoes is governed by complex molecular and cellular interactions that we are just beginning…”
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Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes by Waterhouse, Robert M, Kriventseva, Evgenia V, Meister, Stephan, Xi, Zhiyong, Alvarez, Kanwal S, Bartholomay, Lyric C, Barillas-Mury, Carolina, Bian, Guowu, Blandin, Stephanie, Christensen, Bruce M, Dong, Yuemei, Jiang, Haobo, Kanost, Michael R, Koutsos, Anastasios C, Levashina, Elena A, Li, Jianyong, Ligoxygakis, Petros, MacCallum, Robert M, Mayhew, George F, Mendes, Antonio, Michel, Kristin, Osta, Mike A, Paskewitz, Susan, Shin, Sang Woon, Vlachou, Dina, Wang, Lihui, Wei, Weiqi, Zheng, Liangbiao, Zou, Zhen, Severson, David W, Raikhel, Alexander S, Kafatos, Fotis C, Dimopoulos, George, Zdobnov, Evgeny M, Christophides, George K

“…Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and…”
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Effects of Mosquito Genes on Plasmodium Development by Osta, Mike A., Christophides, George K., Kafatos, Fotis C.

“…Malaria parasites must complete a complex developmental cycle in an Anopheles mosquito vector before transmission to a vertebrate host. Sexual development of…”
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