Search Results - "Osslund, Timothy D."

Crystallization and liquid-liquid phase separation of monoclonal antibodies and fc-fusion proteins: Screening results by Trilisky, Egor, Gillespie, Ronald, Osslund, Timothy D., Vunnum, Suresh

“…Crystallization holds the potential to be used for protein purification and low‐viscosity drug substance and drug product formulations. Twenty‐two different…”
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Crystal Structure of Murine 11β-Hydroxysteroid Dehydrogenase 1:  An Important Therapeutic Target for Diabetes by Zhang, Jiandong, Osslund, Timothy D, Plant, Matthew H, Clogston, Christi L, Nybo, Rebecca E, Xiong, Fei, Delaney, John M, Jordan, Steven R

“…11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the conversion of 11-dehydrocorticosterone to its active form corticosterone in rodents (or…”
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Efficiency of signalling through cytokine receptors depends critically on receptor orientation by Syed, Rashid S, Reid, Scott W, Li, Cuiwei, Cheetham, Janet C, Aoki, Kenneth H, Liu, Beishan, Zhan, Hangjun, Osslund, Timothy D, Chirino, Arthur J, Zhang, Jiandong, Finer-Moore, Janet, Elliott, Steven, Sitney, Karen, Katz, Bradley A, Matthews, David J, Wendoloski, John J, Egrie, Joan, Stroud, Robert M

“…Human erythropoietin is a haematopoietic cytokine required for the differentiation and proliferation of precursor cells into red blood cells. It activates…”
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Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors by RZASA, Robert M, KALLER, Matthew R, XIAOLING XIONG, WENGE ZHONG, NORMAN, Mark H, GANG LIU, MAGAL, Ella, NGUYEN, Thomas T, OSSLUND, Timothy D, POWERS, David, SANTORA, Vincent J, VISWANADHAN, Vellarkad N, WANG, Hui-Ling

“…Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that plays a critical role in the early development of the nervous system. Deregulation of CDK5…”
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Design and synthesis of quinolin-2(1 H)-one derivatives as potent CDK5 inhibitors by Zhong, Wenge, Liu, Hu, Kaller, Matthew R., Henley, Charles, Magal, Ella, Nguyen, Thomas, Osslund, Timothy D., Powers, David, Rzasa, Robert M., Wang, Hui-Ling, Wang, Weiya, Xiong, Xiaoling, Zhang, Jiandong, Norman, Mark H.

“…A novel series of quinolin-2(1 H)-one derivatives were synthesized and found to have potent CDK5 inhibitory activities. Cyclin-dependent kinase 5 (CDK5) is a…”
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Structure of the active core of human stem cell factor and analysis of binding to its receptor Kit by Jiang, Xuliang, Gurel, Ogan, Mendiaz, Elizabeth A., Stearns, George W., Clogston, Christi L., Lu, Hsieng S., Osslund, Timothy D., Syed, Rashid S., Langley, Keith E., Hendrickson, Wayne A.

“…Stem cell factor (SCF) is an early‐acting hematopoietic cytokine that elicits multiple biological effects. SCF is dimeric and occurs in soluble and…”
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The Structure of Granulocyte-Colony-Stimulating Factor and its Relationship to Other Growth Factors by Hill, Christopher P., Osslund, Timothy D., Eisenberg, David

“…We have determined the three-dimensional structure of recombinant human granulocyte-colony-stimulating factor by x-ray crystallography. Phases were initially…”
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Expression of Naphthalene Oxidation Genes in Escherichia coli Results in the Biosynthesis of Indigo by Ensley, Burt D., Ratzkin, Barry J., Osslund, Timothy D., Simon, Mary J., Wackett, Lawrence P., Gibson, David T.

“…A fragment of plasmid NAH7 from Pseudomonas putida PpG7 has been cloned and expressed in Escherichia coli HB101. Growth of the recombinant Escherichia coli in…”
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Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4 by Simon, M J, Osslund, T D, Saunders, R, Ensley, B D, Suggs, S, Harcourt, A, Suen, W C, Cruden, D L, Gibson, D T, Zylstra, G J

“…The multicomponent enzyme, naphthalene dioxygenase, initiates the metabolism of naphthalene by Pseudomonas putida strains G7 (PpG7) and NCIB 9816-4 (Pp9816-4)…”
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Structure–activity relationships of 3,4-dihydro-1 H-quinazolin-2-one derivatives as potential CDK5 inhibitors by Rzasa, Robert M., Kaller, Matthew R., Liu, Gang, Magal, Ella, Nguyen, Thomas T., Osslund, Timothy D., Powers, David, Santora, Vincent J., Viswanadhan, Vellarkad N., Wang, Hui-Ling, Xiong, Xiaoling, Zhong, Wenge, Norman, Mark H.

“…3,4-Dihydroquinazolin-2(1 H)-one derivatives have been synthesized and evaluated for their inhibition of cyclin-dependent kinase 5. Cyclin-dependent kinase 5…”
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Correlation between the 1.6 Å crystal structure and mutational analysis of keratinocyte growth factor by Osslund, Timothy D., Syed, Rashid, Singer, Elizabeth, Hsu, Eric W.‐J., Nybo, Rebecca, Harvey, Timothy, Arakawa, Tsutomu, Narhi, Linda Owers, Chirino, Arthur, Morris, Charles F., Chen, Bao‐Lu

“…A comprehensive deletion, mutational, and structural analysis of the native recombinant keratinocyte growth factor (KGF) polypeptide has resulted in the…”
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Crystallization and preliminary structural studies of neurotrophin‐3 by Kelly, Jennifer A., Singer, Elizabeth, Osslund, Timothy D., Yeates, Todd O.

“…Neurotrophin‐3 (NT‐3) has been crystallized in 2 forms. Orthorhombic crystals, space group P21212, diffracted to 2.8 Å and have cell dimensions a = 39.1 Å, b =…”
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