Search Results - "Ospina, Jason K"

Actin-dependent intranuclear repositioning of an active gene locus in vivo by Dundr, Miroslav, Ospina, Jason K, Sung, Myong-Hee, John, Sam, Upender, Madhvi, Ried, Thomas, Hager, Gordon L, Matera, A. Gregory

“…Although bulk chromatin is thought to have limited mobility within the interphase eukaryotic nucleus, directed long-distance chromosome movements are not…”
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Two Distinct Arginine Methyltransferases Are Required for Biogenesis of Sm-Class Ribonucleoproteins by Gonsalvez, Graydon B., Tian, Liping, Ospina, Jason K., Boisvert, François-Michel, Lamond, Angus I., Matera, A. Gregory

“…Small nuclear ribonucleoproteins (snRNPs) are core components of the spliceosome. The U1, U2, U4, and U5 snRNPs each contain a common set of seven Sm proteins…”
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In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling by Du, Juan, Zhang, Junzheng, Su, Ying, Liu, Min, Ospina, Jason K, Yang, Shengyuan, Zhu, Alan Jian

“…Hedgehog (Hh) signaling is highly conserved in all metazoan animals and plays critical roles in many developmental processes. Dysregulation of the Hh signaling…”
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Sequential phosphorylation of smoothened transduces graded hedgehog signaling by Su, Ying, Ospina, Jason K, Zhang, Junzheng, Michelson, Andrew P, Schoen, Adam M, Zhu, Alan Jian

“…The correct interpretation of a gradient of the morphogen Hedgehog (Hh) during development requires phosphorylation of the Hh signaling activator Smoothened…”
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PHAX and CRM1 Are Required Sequentially to Transport U3 snoRNA to Nucleoli by Boulon, Séverine, Verheggen, Céline, Jady, Beata E., Girard, Cyrille, Pescia, Christina, Paul, Conception, Ospina, Jason K., Kiss, Tamas, Matera, A.Gregory, Bordonné, Rémy, Bertrand, Edouard

“…To better understand intranuclear-targeting mechanisms, we have studied the transport of U3 snoRNA in human cells. Surprisingly, we found that PHAX, the snRNA…”
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Coilin Methylation Regulates Nuclear Body Formation by Hebert, Michael D., Shpargel, Karl B., Ospina, Jason K., Tucker, Karen E., Matera, A.Gregory

“…Cajal bodies (CBs) are nuclear suborganelles involved in biogenesis of small RNAs. Twin structures, called gems, contain high concentrations of the survival…”
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SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin β by Narayanan, Usha, Ospina, Jason K., Frey, Mark R., Hebert, Michael D., Matera, A. Gregory

“…The survival of motor neuron (SMN) protein is mutated in patients with spinal muscular atrophy (SMA). SMN is part of a multiprotein complex required for…”
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Control of Cajal body number is mediated by the coilin C-terminus by Shpargel, Karl B, Ospina, Jason K, Tucker, Karen E, Matera, A Gregory, Hebert, Michael D

“…Cajal bodies (CBs) are nuclear suborganelles implicated in the post-transcriptional maturation of small nuclear and small nucleolar RNAs. The number of CBs…”
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Cross-talk between snurportin1 subdomains by Ospina, Jason K, Gonsalvez, Graydon B, Bednenko, Janna, Darzynkiewicz, Edward, Gerace, Larry, Matera, A Gregory

“…The initial steps of spliceosomal small nuclear ribonucleoprotein (snRNP) maturation take place in the cytoplasm. After formation of an Sm-core and a…”
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Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein by Wagner, Eric J, Ospina, Jason K, Hu, Yue, Dundr, Miroslav, Matera, A Gregory, Marzluff, William F

“…Formation of the 3' end of replication-dependent histone mRNAs is most robust during S phase and is mediated by both the stem-loop binding protein (SLBP) and…”
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Cross-Talk between Snurportin1 SubdomainsD by Ospina, Jason K., Gonsalvez, Graydon B., Bednenko, Janna, Darzynkiewicz, Edward, Gerace, Larry, Matera, A. Gregory

“…The initial steps of spliceosomal small nuclear ribonucleoprotein (snRNP) maturation take place in the cytoplasm. After formation of an Sm-core and a…”
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Proteomics: The Nucleolus Weighs In Dispatch by Ospina, J K, Matera, A G

“…Numerous studies have indicated that the nucleolus is involved in a variety of cellular processes besides its well-known function in ribosome biosynthesis. A…”
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Proteomics: The Nucleolus Weighs In by Ospina, Jason K, Matera, A.Gregory

“…Numerous studies have indicated that the nucleolus is involved in a variety of cellular processes besides its well-known function in ribosome biosynthesis. A…”
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SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin [beta] by Narayanan, Usha, Ospina, Jason K, Frey, Mark R, Hebert, Michael D, Matera, A Gregory

“…The survival of motor neuron (SMN) protein is mutated in patients with spinal muscular atrophy (SMA). SMN is part of a multiprotein complex required for…”
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