The OLGA-OLGIM staging and the interobserver agreement for gastritis and preneoplastic lesion screening: a cross-sectional study

Stomach cancer (SC) incidence and mortality are relevant public health issues worldwide. In Colombia, screening for preneoplastic lesions (PNL) and the presence of H. pylori is not routinely performed. Therefore, the aim of this study was to evaluate OLGA-OLGIM staging and the interobserver agreemen...

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Published in:	Virchows Archiv : an international journal of pathology Vol. 480; no. 4; pp. 759 - 769
Main Authors:	Salazar, Beatriz E., Pérez-Cala, Tania, Gomez-Villegas, Sara Isabel, Cardona-Zapata, Laura, Pazos-Bastidas, Sebastián, Cardona-Estepa, Alejandra, Vélez-Gómez, Diego Enrique, Justinico-Castro, José Armando, Bernal-Cobo, Andrés, Dávila-Giraldo, Harold Adrián, Benítez-Guerra, Juan Carlos, Valencia-Cárdenas, Joaquín Tiberio, Ospina, Edgar de Jesús, Castaño-Llano, Rodrigo, Bravo, María Mercedes, Cataño-Correa, Juan Carlos, Zabaleta, Jovanny, Trespalacios-Rangel, Alba Alicia, Cock-Botero, Ana María, Roldán-Pérez, Miguel Ignacio, Martínez, Alonso
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-04-2022 Springer Nature B.V
Subjects:	Asymptomatic Atrophy Biopsy Cancer therapies Cellular biology Chronic illnesses Coffee Cross-Sectional Studies Evaluation Gastric cancer Gastritis Gastritis - diagnosis Gastritis, Atrophic - complications Gastritis, Atrophic - diagnosis Gastritis, Atrophic - pathology Helicobacter Infections - complications Helicobacter Infections - diagnosis Helicobacter pylori Histopathology Humans Infections Infectious diseases Lesions Medical prognosis Medicine Medicine & Public Health Metaplasia Mortality Observer Variation Original Article Pathology Precancerous Conditions - diagnosis Precancerous Conditions - pathology Public health Reading Risk Factors Stomach Neoplasms - diagnosis Stomach Neoplasms - pathology Colombia OLGA OLGIM Histopathology Gastroduodenal diseases
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Summary:	Stomach cancer (SC) incidence and mortality are relevant public health issues worldwide. In Colombia, screening for preneoplastic lesions (PNL) and the presence of H. pylori is not routinely performed. Therefore, the aim of this study was to evaluate OLGA-OLGIM staging and the interobserver agreement in gastritis and preneoplastic lesions in patients with gastroduodenal symptoms from Colombia. A cross-sectional study was conducted in 272 patients with gastroduodenal symptoms. Gastric biopsies were taken following the Updated Sydney System with the OLGA-OLGIM classification, and the results were evaluated by two pathologists. Chronic gastritis and PNL were reported in 76% and 24% of the patients, respectively. Furthermore, 25% of the patients with PNL displayed gastric atrophy (GA) and 75% intestinal metaplasia (IM). Agreement in the histopathological reading for IM was good, whereas for OLGA was variable, and for the H. pylori quantity was poor. OLGA-OLGIM stages 0-II were the most frequent (96%), while stage III (4%) and SC (4%) were the least frequent. Age and coffee consumption were associated with a higher prevalence of PNL. This work determined that 4% of the population is at high risk of developing SC and would benefit from follow-up studies. Reinforcement of training programs to improve the agreement in histopathology readings is required.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0945-6317 1432-2307
DOI:	10.1007/s00428-022-03286-8