Search Results - "Osorio, Yaneth E"

Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype by Kong, Fanping, Saldarriaga, Omar A, Spratt, Heidi, Osorio, E Yaneth, Travi, Bruno L, Luxon, Bruce A, Melby, Peter C

“…Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is characterized by relentlessly increasing visceral parasite…”
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Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE2-mediated amplification of CCR7-related trafficking of infected inflammatory monocytes by Osorio, E Yaneth, Uscanga-Palomeque, Ashanti, Patterson, Grace T, Cordova, Erika, Travi, Bruno L, Soong, Lynn, Melby, Peter C

“…People are infected with Leishmania donovani when the parasite is deposited in the dermis during the blood meal of the sand fly vector. Most infected people…”
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In-situ proliferation contributes to the accumulation of myeloid cells in the spleen during progressive experimental visceral leishmaniasis by Osorio, E Yaneth, Medina-Colorado, Audrie A, Travi, Bruno L, Melby, Peter C

“…Visceral leishmaniasis (VL) is characterized by expansion of myeloid cells in the liver and spleen, which leads to a severe splenomegaly associated with higher…”
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Inflammatory stimuli alter bone marrow composition and compromise bone health in the malnourished host by Osorio, E. Yaneth, Gugala, Zbigniew, Patterson, Grace T., Palacios, Genesis, Cordova, Erika, Uscanga-Palomeque, Ashanti, Travi, Bruno L., Melby, Peter C.

“…Inflammation has a role in the pathogenesis of childhood malnutrition. We investigated the effect of malnutrition and inflammatory challenge on bone marrow…”
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A secondary wave of neutrophil infiltration causes necrosis and ulceration in lesions of experimental American cutaneous leishmaniasis by Peniche, Alex G, Bonilla, Diana L, Palma, Gloria I, Melby, Peter C, Travi, Bruno L, Osorio, E Yaneth

“…We evaluated the importance of neutrophils in the development of chronic lesions caused by L. Viannia spp. using the hamster as experimental model of American…”
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Efficacy of histamine H1 receptor antagonists azelastine and fexofenadine against cutaneous Leishmania major infection by Peniche, Alex G, Osorio, E Yaneth, Melby, Peter C, Travi, Bruno L

“…Current drug therapies for cutaneous leishmaniasis are often difficult to administer and treatment failure is an increasingly common occurrence. The efficacy…”
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Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis by Osorio, E Yaneth, Travi, Bruno L, da Cruz, Alda M, Saldarriaga, Omar A, Medina, Audrie A, Melby, Peter C

“…Host arginase 1 (arg1) expression is a significant contributor to the pathogenesis of progressive visceral leishmaniasis (VL), a neglected tropical disease…”
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Double Staining with Fluorescent Tracers to Determine Myeloid Cell Migration of Leishmania -infected Cells from Mouse Skin to Lymphatic Tissues by Flow Cytometry by Uscanga-Palomeque, Ashanti C, Osorio, Yaneth E, Melby, Peter C

“…Immune cell trafficking in steady-state conditions and inflammatory cell recruitment into injured tissues is crucial for the surveillance of the immune system…”
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Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression by Osorio, E Yaneth, Zhao, Weiguo, Espitia, Claudia, Saldarriaga, Omar, Hawel, Leo, Byus, Craig V, Travi, Bruno L, Melby, Peter C

“…The clinicopathological features of the hamster model of visceral leishmaniasis (VL) closely mimic active human disease. Studies in humans and hamsters…”
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The malnutrition-related increase in early visceralization of Leishmania donovani is associated with a reduced number of lymph node phagocytes and altered conduit system flow by Ibrahim, Marwa K, Barnes, Jeffrey L, Anstead, Gregory M, Jimenez, Fabio, Travi, Bruno L, Peniche, Alex G, Osorio, E Yaneth, Ahuja, Seema S, Melby, Peter C

“…In a murine model of moderate childhood malnutrition we found that polynutrient deficiency led to a 4-5-fold increase in early visceralization of L. donovani…”
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Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection by Ibrahim, Marwa K, Barnes, Jeffrey L, Osorio, E Yaneth, Anstead, Gregory M, Jimenez, Fabio, Osterholzer, John J, Travi, Bruno L, Ahuja, Seema S, White, Jr, A Clinton, Melby, Peter C

“…Malnutrition is thought to contribute to more than one-third of all childhood deaths via increased susceptibility to infection. Malnutrition is a significant…”
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Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes by Espitia, Claudia M, Saldarriaga, Omar A, Travi, Bruno L, Osorio, E Yaneth, Hernandez, Alvaro, Band, Mark, Patel, Mandakini J, Medina, Audrie A, Cappello, Michael, Pekosz, Andrew, Melby, Peter C

“…The Syrian golden hamster (Mesocricetus aureus) has been used as a model to study infections caused by a number of human pathogens. Studies of…”
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Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE.sub.2-mediated amplification of CCR7-related trafficking of infected inflammatory monocytes by Osorio, E. Yaneth, Uscanga-Palomeque, Ashanti, Patterson, Grace T, Cordova, Erika, Travi, Bruno L, Soong, Lynn, Melby, Peter C

“…People are infected with Leishmania donovani when the parasite is deposited in the dermis during the blood meal of the sand fly vector. Most infected people…”
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Growth Factor and Th2 Cytokine Signaling Pathways Converge at STAT6 to Promote Arginase Expression in Progressive Experimental Visceral Leishmaniasis: e1004165 by Osorio, E Yaneth, Travi, Bruno L, Cruz, Alda Mda, Saldarriaga, Omar A, Medina, Audrie A, Melby, Peter C

“…Host arginase 1 (arg1) expression is a significant contributor to the pathogenesis of progressive visceral leishmaniasis (VL), a neglected tropical disease…”
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The Malnutrition-Related Increase in Early Visceralization of Leishmania donovani Is Associated with a Reduced Number of Lymph Node Phagocytes and Altered Conduit System Flow: e2329 by Ibrahim, Marwa K, Barnes, Jeffrey L, Anstead, Gregory M, Jimenez, Fabio, Travi, Bruno L, Peniche, Alex G, Osorio, E Yaneth, Ahuja, Seema S, Melby, Peter C

“…In a murine model of moderate childhood malnutrition we found that polynutrient deficiency led to a 4-5-fold increase in early visceralization of L. donovani…”
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An ex vivo splenic explant model system for the identification of small molecule therapeutics for visceral leishmaniasis by Osorio, Yaneth E., Travi, Bruno L., Melby, Peter C.

“…Abstract only New therapies for leishmaniasis are needed. We established an ex vivo splenic explant culture system from hamsters infected with…”
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Dominant arginase expression in a model of progressive visceral leishmaniasis by Osorio, Yaneth E., Zhao, Weiguo, Espitia, Claudia, Travi, Bruno L., Hawel, Leo, Byus, Craig V., Saldarriaga, Omar A., Melby, Peter C.

“…Abstract only Progressive disease in the hamster model of visceral leishmaniasis (VL), caused by Leishmania donovani, mimics human VL. During progressive…”
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