Molecular characterization of lumpy skin disease virus (LSDV) emerged in Bangladesh reveals unique genetic features compared to contemporary field strains

Molecular characterization of lumpy skin disease virus (LSDV) emerged in Bangladesh reveals unique genetic features compared to contemporary field strains

Lumpy skin disease (LSD) is a contagious viral disease of cattle caused by lumpy skin disease virus (LSDV). LSD has recently spread in Asia following outbreaks in the Middle East and Europe. The disease emerged in Bangladesh in July 2019 in the Chattogram district, then rapidly spread throughout the...

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Bibliographic Details
Published in:BMC veterinary research Vol. 17; no. 1; p. 61
Main Authors: Badhy, Shukes Chandra, Chowdhury, Mohammad Golam Azam, Settypalli, Tirumala Bharani Kumar, Cattoli, Giovanni, Lamien, Charles Euloge, Fakir, Mohammad Aflak Uddin, Akter, Shamima, Osmani, Mozaffar Goni, Talukdar, Faisol, Begum, Noorjahan, Khan, Izhar Ahmed, Rashid, Md Bazlur, Sadekuzzaman, Mohammad
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 29-01-2021
BioMed Central
BMC
Subjects:
Bangladesh
Cattle
Causes of
Disease
Diseases
Distribution
DNA virus infections
DNA viruses
EEV glycoprotein
Epidemics
Epidemiology
Fever
G protein-coupled receptors
Genes
Genetic aspects
Genomes
Glycoproteins
GPCR
Identification and classification
Lumpy skin disease
Lumpy skin disease virus;Capripoxvirus;RPO30
Outbreaks
Phylogenetics
Phylogeny
Risk factors
Skin
Skin diseases
Strains (organisms)
Vaccines
Viral diseases
Viruses
Bangladesh
Middle East
Europe
China
Africa
Kenya
Russia
GPCR
Bangladesh
Lumpy skin disease virus;Capripoxvirus;RPO30
EEV glycoprotein
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Summary:Lumpy skin disease (LSD) is a contagious viral disease of cattle caused by lumpy skin disease virus (LSDV). LSD has recently spread in Asia following outbreaks in the Middle East and Europe. The disease emerged in Bangladesh in July 2019 in the Chattogram district, then rapidly spread throughout the entire country. We investigated six LSD outbreaks in Bangladesh to record the clinical signs and collect samples for diagnostic confirmation. Furthermore, we performed the molecular characterization of Bangladesh isolates, analyzing the full RPO30 and GPCR genes and the partial EEV glycoprotein gene. Clinical observations revealed common LSD clinical signs in the affected cattle. PCR and real-time PCR, showed the presence of the LSDV genome in samples from all six districts. Phylogenetic analysis and detailed inspection of multiple sequence alignments revealed that Bangladesh isolates differ from common LSDV field isolates encountered in Africa, the Middle East, and Europe, as well as newly emerged LSDV variants in Russia and China. Instead, they were closely related to LSDV KSGP-0240, LSDV NI2490, and LSDV Kenya. These results show the importance of continuous monitoring and characterization of circulating strains and the need to continually refine the strategies for differentiating vaccine strains from field viruses.
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ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-021-02751-x