Search Results - "Osmand, Alexander"

Critical role of microRNA-155 in herpes simplex encephalitis by Bhela, Siddheshvar, Mulik, Sachin, Reddy, Pradeep B J, Richardson, Raphael L, Gimenez, Fernanda, Rajasagi, Naveen K, Veiga-Parga, Tamara, Osmand, Alexander P, Rouse, Barry T

“…HSV infection of adult humans occasionally results in life-threatening herpes simplex encephalitis (HSE) for reasons that remain to be defined. An animal…”
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A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease by Yu-Taeger, Libo, Petrasch-Parwez, Elisabeth, Osmand, Alexander P, Redensek, Adriana, Metzger, Silke, Clemens, Laura E, Park, Larry, Howland, David, Calaminus, Carsten, Gu, Xiaofeng, Pichler, Bernd, Yang, X William, Riess, Olaf, Nguyen, Huu Phuc

“…Huntington disease (HD) is an inherited progressive neurodegenerative disorder, characterized by motor, cognitive, and psychiatric deficits as well as…”
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Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment by Blockx, Ines, De Groof, Geert, Verhoye, Marleen, Van Audekerke, Johan, Raber, Kerstin, Poot, Dirk, Sijbers, Jan, Osmand, Alexander P., Von Hörsten, Stephan, Van der Linden, Annemie

“…Huntington Disease (HD) is a fatal neurodegenerative disorder, caused by a mutation in the Huntington gene. Although HD is most often diagnosed in mid-life,…”
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Absence of Behavioral Abnormalities and Neurodegeneration in vivo despite Widespread Neuronal Huntingtin Inclusions by Slow, Elizabeth J., Graham, Rona K., Osmand, Alexander P., Devon, Rebecca S., Lu, Ge, Deng, Yu, Pearson, Jacqui, Vaid, Kuljeet, Bissada, Nagat, Wetzel, Ronald, Leavitt, Blair R., Hayden, Michael R., Palmiter, Richard D.

“…We have serendipitously established a mouse that expresses an N-terminal human huntingtin (htt) fragment with an expanded polyglutamine repeat (≈120) under the…”
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Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation by Alexandru, Anca, Jagla, Wolfgang, Graubner, Sigrid, Becker, Andreas, Bäuscher, Christoph, Kohlmann, Stephanie, Sedlmeier, Reinhard, Raber, Kerstin A, Cynis, Holger, Rönicke, Raik, Reymann, Klaus G, Petrasch-Parwez, Elisabeth, Hartlage-Rübsamen, Maike, Waniek, Alexander, Rossner, Steffen, Schilling, Stephan, Osmand, Alexander P, Demuth, Hans-Ulrich, von Hörsten, Stephan

“…Posttranslational amyloid-β (Aβ) modification is considered to play an important role in Alzheimer's disease (AD) etiology. An N-terminally modified Aβ…”
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Coexistence of Huntington’s disease and amyotrophic lateral sclerosis: a clinicopathologic study by Tada, Mari, Coon, Elizabeth A., Osmand, Alexander P., Kirby, Patricia A., Martin, Wayne, Wieler, Marguerite, Shiga, Atsushi, Shirasaki, Hiroe, Tada, Masayoshi, Makifuchi, Takao, Yamada, Mitsunori, Kakita, Akiyoshi, Nishizawa, Masatoyo, Takahashi, Hitoshi, Paulson, Henry L.

“…We report a retrospective case series of four patients with genetically confirmed Huntington’s disease (HD) and sporadic amyotrophic lateral sclerosis (ALS),…”
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IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes by Becker, Andreas, Eichentopf, Rico, Sedlmeier, Reinhard, Waniek, Alexander, Cynis, Holger, Koch, Birgit, Stephan, Anett, Bäuscher, Christoph, Kohlmann, Stephanie, Hoffmann, Torsten, Kehlen, Astrid, Berg, Sabine, Freyse, Ernst-Joachim, Osmand, Alexander, Plank, Anne-Christine, Roßner, Steffen, von Hörsten, Stephan, Graubner, Sigrid, Demuth, Hans-Ulrich, Schilling, Stephan

“…Secretory peptides and proteins are frequently modified by pyroglutamic acid (pE, pGlu) at their N-terminus. This modification is catalyzed by the glutaminyl…”
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Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington's Disease by Osmand, Alexander P, Bichell, Terry Jo, Bowman, Aaron B, Bates, Gillian P

“…The role of aggregate formation in the pathophysiology of Huntington's disease (HD) remains uncertain. However, the temporal appearance of aggregates tends to…”
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Imaging polyglutamine deposits in brain tissue by Osmand, Alexander P, Berthelier, Valerie, Wetzel, Ronald

“…The formation of polyglutamine aggregates occupies a central role in the pathophysiology of neurodegenerative diseases caused by expanded trinucleotide repeats…”
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Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype by Wegrzynowicz, Michal, Bichell, Terry Jo, Soares, Barbara D, Loth, Meredith K, McGlothan, Jennifer S, Mori, Susumu, Alikhan, Fatima S, Hua, Kegang, Coughlin, Jennifer M, Holt, Hunter K, Jetter, Christopher S, Pomper, Martin G, Osmand, Alexander P, Guilarte, Tomás R, Bowman, Aaron B

“…Unusually large CAG repeat expansions (>60) in exon one of Huntingtin (HTT) are invariably associated with a juvenile-onset form of Huntington's disease (HD),…”
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αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease by Oliveira, Ana Osório, Osmand, Alexander, Outeiro, Tiago Fleming, Muchowski, Paul Joseph, Finkbeiner, Steven

“…Huntington's disease (HD) is caused by an expanded polyglutamine (polyQ) tract in the huntingtin (htt) protein. The polyQ expansion increases the propensity of…”
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Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition by Siebzehnrübl, Florian A., Raber, Kerstin A., Urbach, Yvonne K., Schulze-Krebs, Anja, Canneva, Fabio, Moceri, Sandra, Habermeyer, Johanna, Achoui, Dalila, Gupta, Bhavana, Steindler, Dennis A., Stephan, Michael, Nguyen, Huu Phuc, Bonin, Michael, Riess, Olaf, Bauer, Andreas, Aigner, Ludwig, Couillard-Despres, Sebastien, Paucar, Martin Arce, Svenningsson, Per, Osmand, Alexander, Andreew, Alexander, Zabel, Claus, Weiss, Andreas, Kuhn, Rainer, Moussaoui, Saliha, Blockx, Ines, Van der Linden, Annemie, Cheong, Rachel Y., Roybon, Laurent, Petersén, Åsa, von Hörsten, Stephan

“…Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is…”
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Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model by Bichell, Terry Jo V., Wegrzynowicz, Michal, Tipps, K. Grace, Bradley, Emma M., Uhouse, Michael A., Bryan, Miles, Horning, Kyle, Fisher, Nicole, Dudek, Karrie, Halbesma, Timothy, Umashanker, Preethi, Stubbs, Andrew D., Holt, Hunter K., Kwakye, Gunnar F., Tidball, Andrew M., Colbran, Roger J., Aschner, Michael, Neely, M. Diana, Di Pardo, Alba, Maglione, Vittorio, Osmand, Alexander, Bowman, Aaron B.

“…Huntington's disease (HD) is caused by a mutation in the huntingtin gene (HTT), resulting in profound striatal neurodegeneration through an unknown mechanism…”
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Expression and distribution of the dentatorubral-pallidoluysian atrophy gene product (atrophin-1/drplap) in neuronal and non-neuronal tissues by Knight, Steven P, Richardson, Matthew M, Osmand, Alexander P, Stakkestad, Anna, Potter, Nicholas T

“…Utilizing an affinity-purified antiserum directed against the carboxyl terminal region of atrophin-1/drplap (residues 1170–1185), we have examined the…”
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Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease by Nguyen, Huu Phuc, Kobbe, Philipp, Rahne, Henning, Wörpel, Till, Jäger, Burkard, Stephan, Michael, Pabst, Reinhard, Holzmann, Carsten, Riess, Olaf, Korr, Hubert, Kántor, Orsolya, Petrasch-Parwez, Elisabeth, Wetzel, Ronald, Osmand, Alexander, von Hörsten, Stephan

“…Huntington's disease (HD) is caused by an expanded CAG repeat leading to the synthesis of an aberrant protein and to the formation of polyglutamine…”
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Critical role of miR-155 in herpes simplex encephalitis by Bhela, Siddheshvar, Mulik, Sachin, Reddy, Pradeep B. J., Ricardson, Raphael L., Gimenez, Fernanda, Rajasagi, Naveen K, Veiga-Parga, Tamara, Osmand, Alexander P., Rouse, Barry T.

“…Herpes simplex virus (HSV) infection of adult humans occasionally results in life-threatening herpes simplex encephalitis (HSE) for reasons that remain to be…”
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Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models by Franich, Nicholas R, Basso, Manuela, André, Emily A, Ochaba, Joseph, Kumar, Amit, Thein, Soe, Fote, Gianna, Kachemov, Marketta, Lau, Alice L, Yeung, Sylvia Y, Osmand, Alexander, Zeitlin, Scott O, Ratan, Rajiv R, Thompson, Leslie M, Steffan, Joan S

“…Huntington's disease (HD) is a progressive neurodegenerative disorder associated with aging, caused by an expanded polyglutamine (polyQ) repeat within the…”
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Interaction of C-Reactive Protein with Lymphocytes and Monocytes: Complement-Dependent Adherence and Phagocytosis by Mortensen, Richard F, Osmand, Alexander P, Lint, Thomas F, Gewurz, Henry

“…The serum constituent C-reactive protein (CRP), which activates the classical complement (C) pathway when reacting with its substrates, was examined for its…”
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Liquid caustic ingestions: an in vitro study of the effects of buffer, neutralization, and dilution by Maull, K I, Osmand, A P, Maull, C D

“…Changes in pH and temperature of solutions of common commercial liquid caustics were determined in vitro following the addition of neutralizing agent, buffer,…”
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Inhibition of platelet aggregation by a myeloma protein with anti-phosphocholine specificity by FIEDEL, BARRY A, OSMAND, ALEXANDER P, GEWURZ, HENRY

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