Search Results - "Osman, Shaaban K."

Current and Future Prospective of Injectable Hydrogels-Design Challenges and Limitations by Almawash, Saud, Osman, Shaaban K, Mustafa, Gulam, El Hamd, Mohamed A

“…Injectable hydrogels (IHs) are smart biomaterials and are the most widely investigated and versatile technologies, which can be either implanted or inserted…”
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Gefitinib-loaded starch nanoparticles for battling lung cancer: Optimization by full factorial design and in vitro cytotoxicity evaluation by Amin, Haitham, Osman, Shaaban K., Mohammed, Ahmed M., Zayed, Gamal

“…Lung cancer is the number one killer among all cancer types. For decades, clinicians have been using conventional chemotherapeutics, but they can’t rely on…”
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Polymerized β-Cyclodextrin-Based Injectable Hydrogel for Sustained Release of 5-Fluorouracil/Methotrexate Mixture in Breast Cancer Management: In Vitro and In Vivo Analytical Validations by Almawash, Saud, El Hamd, Mohamed A, Osman, Shaaban K

“…An inclusion complexation, between polymerized β-cyclodextrin and cholesterol end-capping branched polyethylene glycol, was utilized for constructing a…”
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Smart Injectable Chitosan Hydrogels Loaded with 5-Fluorouracil for the Treatment of Breast Cancer by Abdellatif, Ahmed A H, Mohammed, Ahmed M, Saleem, Imran, Alsharidah, Mansour, Al Rugaie, Osamah, Ahmed, Fatma, Osman, Shaaban K

“…The treatment of breast cancer requires long chemotherapy management, which is accompanied by severe side effects. Localized delivery of anticancer drugs helps…”
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Silver Nanoparticles Stabilized by Poly (Vinyl Pyrrolidone) with Potential Anticancer Activity towards Prostate Cancer by Abdellatif, Ahmed A. H., Abdelfattah, Ahmed, Bouazzaoui, Abdellatif, Osman, Shaaban K., Al-Moraya, Issa Saad, Showail, Abdulaziz M. Saleh, Alsharidah, Mansour, Aboelela, Ashraf, Al Rugaie, Osamah, Faris, Tarek M., Tawfeek, Hesham M.

“…Tumor necrosis factor (TNF-α) and inflammatory cytokine (IL-6) play a vital role in various cellular incidents such as the proliferation and death of cells…”
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A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application by Osman, Shaaban K., Yassin, Taher M., Mohammed, Ahmed M., Alfayomy, Abdallah M., Abdellatif, Ahmed A., Mahdi, Wael A., Alshehri, Sultan, Hamd, Mohamed A. El, Sarhan, Hatem, Ibrahim, Mohammed A.

“…Tenoxicam (TX) is a non-steroidal anti-inflammatory agent that can be used to control pain in various ophthalmic lesions like cataracts, refractive surgery,…”
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Injectable Hydrogels Based on Cyclodextrin/Cholesterol Inclusion Complexation and Loaded with 5-Fluorouracil/Methotrexate for Breast Cancer Treatment by Almawash, Saud, Mohammed, Ahmed M, El Hamd, Mohamed A, Osman, Shaaban K

“…Breast cancer is the second most common cancer in women worldwide. Long-term treatment with conventional chemotherapy may result in severe systemic side…”
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Physically cross-linked hydrogels of β -cyclodextrin polymer and poly(ethylene glycol)-cholesterol as delivery systems for macromolecules and small drug molecules by Osman, Shaaban K, Soliman, Ghareb M, El Rasoul, Saleh Abd

“…An injectable hydrogel based on the inclusion complexation of polymerized β-cyclodextrin (pβ-CD) and cholesterol terminated poly(ethylene glycol) (PEG-chol)…”
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Co-crystallization of Hesperidin with different co-formers to enhance solubility, antioxidant and anti-inflammatory activities by Elshaer, Mahmoud, Osman, Shaaban K, Mohammed, Ahmed M, Zayed, Gamal

“…Hesperidin (HSP) is a natural flavonoid glycoside with very low aqueous solubility and a slow dissolution rate, limiting its effectiveness. This study aims to…”
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Chitosan nanoparticles as a smart nanocarrier for gefitinib for tackling lung cancer: Design of experiment and in vitro cytotoxicity study by Amin, Haitham, Amin, Mohammed A., Osman, Shaaban K., Mohammed, Ahmed M., Zayed, Gamal

“…Due to its poor solubility and systemic side effects, gefitinib (Gef) has limited application in treatment of lung cancer. In this study, we used design of…”
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In Vitro Release of 5-Fluorouracil and Methotrexate from Different Thermosensitive Chitosan Hydrogel Systems by Mohammed, Ahmed M., Osman, Shaaban K., Saleh, Khaled I., Samy, Ahmed M.

“…5-Fluorouracil is a member of cytotoxic drugs with poor selectivity to cancer cells. Currently, systemic administration of this anti-cancer drug (oral or…”
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Recent Advances in the Pharmaceutical and Biomedical Applications of Cyclodextrin-Capped Gold Nanoparticles by Abdellatif, Ahmed A H, Ahmed, Fatma, Mohammed, Ahmed M, Alsharidah, Mansour, Al-Subaiyel, Amal, Samman, Waad A, Alhaddad, Aisha A, Al-Mijalli, Samiah Hamad, Amin, Mohammed A, Barakat, Hassan, Osman, Shaaban K

“…The real problem in pharmaceutical preparation is drugs' poor aqueous solubility, low permeability through biological membranes, and short biological t …”
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Cyclodextrin/Adamantane-Grafted Polyethylene Glycol–Based Self-assembling Constructs for Topical Delivery of Ketorolac Tromethamine: Formulation, Characterization, and In Vivo Studies by Abdellatif, Ahmed A. H., Mohammed, Ahmed M., Zayed, Gamal, El-Rasoul, Saleh Abd, Almawash, Saud, Safwat, Mohamed A., Osman, Shaaban K.

“…Topical formulation of non-steroidal anti-inflammatory drugs (NSAIDs) exhibits many advantages over the oral administration route, such as avoiding the direct…”
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Self-assembling Organogels Loaded with Tenoxicam for Local Intensive Pain and Inflammation Cure: In Vitro and In Vivo Correlation by Osman, Shaaban K., Yassin, Taher M., Abdelzaher, Arafat, Ahmed, Fatma, Mohammed, Ahmed M., Abdellatif, Ahmed A. H., Saleh, Khalid I., Mahdi, Wael A., Alshehri, Sultan, Hamd, Mohamed A. El, Sarhan, Hatem

“…Due to tenoxicam (TX)’s poor aqueous solubility (0.072 mg/ml), it is poorly absorbable in the GIT, and the long-term oral administration of TX may cause severe…”
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Cyclodextrin based hydrogels: Inclusion complex formation and micellization of adamantane and cholesterol grafted polymers by Osman, Shaaban K., Brandl, Ferdinand P., Zayed, Gamal M., Teßmar, Jörg K., Göpferich, Achim M.

“…Inclusion complex formation between β-cyclodextrin (β-CD) and suitable guest molecules has frequently been exploited to design self-assembled polymer networks…”
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Formulation and evaluation of different hydrogels loaded with Florite®-based etodolac adsorbate: In vitro and in vivo correlation by Mohammed, Ahmed M., Saleh, Khaled I., Almawash, Saud, El Hamd, Mohamed A., Alsharif, Fahd M., Osman, Shaaban K.

“…Owing to its poor solubility and oral bioavailability, etodolac (ETD), a selective COX-2 inhibitor, was formulated in high-dose oral tablets, which affect the…”
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