Search Results - "Osman, Narin"

Role Played by Signalling Pathways in Overcoming BRAF Inhibitor Resistance in Melanoma by Chan, Xian Yang, Singh, Alamdeep, Osman, Narin, Piva, Terrence J

“…The discovery of the BRAF mutation led to the development of vemurafenib (PLX4032), a selective BRAF inhibitor specific to the kinase, for the treatment of…”
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Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling by Kamato, Danielle, Do, Bich Hang, Osman, Narin, Ross, Benjamin P., Mohamed, Raafat, Xu, Suowen, Little, Peter J.

“…Transforming growth factor (TGF)-β signalling pathways are intensively investigated because of their diverse association with physiological and…”
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Recent advances in the management of diabetic retinopathy by Dulull, Nabeela, Kwa, Faith, Osman, Narin, Rai, Uma, Shaikh, Bilal, Thrimawithana, Thilini R.

“…•Current treatment for diabetic retinopathy targets late stages of the disease.•Promising novel drug candidates include integrin antagonists and Tie-2…”
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Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation by Talati, Nirali, Kamato, Danielle, Piva, Terrence J., Little, Peter J., Osman, Narin

“…Keratinocyte proliferation and migration is essential during re-epithelialisation for the restoration of the epithelial barrier during skin wound healing…”
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Thyroid Hormone Distributor Proteins During Development in Vertebrates by Rabah, Sarah A, Gowan, Indra L, Pagnin, Maurice, Osman, Narin, Richardson, Samantha J

“…Thyroid hormones (THs) are ancient hormones that not only influence the growth, development and metabolism of vertebrates but also affect the metabolism of (at…”
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Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation by Kamato, Danielle, Ta, Hang, Afroz, Rizwana, Xu, Suowen, Osman, Narin, Little, Peter J.

“…Protease activated receptors (PARs) transactivate both epidermal growth factor receptors (EGFR) and transforming growth factor (TGF)-β receptors (TGFBR1) in…”
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Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells by Kamato, Danielle, Gabr, Mai, Kumarapperuma, Hirushi, Chia, Zheng J, Zheng, Wenhua, Xu, Suowen, Osman, Narin, Little, Peter J

“…G protein-coupled receptor (GPCR) transactivation of kinase receptors greatly expands the actions attributable to GPCRs. Thrombin, via its cognate GPCR,…”
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Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes by Kamato, Danielle, Burch, Micah, Zhou, Ying, Mohamed, Raafat, Stow, Jennifer L., Osman, Narin, Zheng, Wenhua, Little, Peter J.

“…Growth factors such as thrombin and transforming growth factor (TGF)-β facilitate glycosaminoglycan (GAG) chain hyperelongation on proteoglycans, a phenomenon…”
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Thrombin-mediated Proteoglycan Synthesis Utilizes Both Protein-tyrosine Kinase and Serine/Threonine Kinase Receptor Transactivation in Vascular Smooth Muscle Cells by Burch, Micah L., Getachew, Robel, Osman, Narin, Febbraio, Mark A., Little, Peter J.

“…G protein-coupled receptor signaling is mediated by three main mechanisms of action; these are the classical pathway, β-arrestin scaffold signaling, and the…”
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RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells by Kamato, Danielle, Bhaskarala, Venkata Vijayanand, Mantri, Nitin, Oh, Tae Gyu, Ling, Dora, Janke, Reearna, Zheng, Wenhua, Little, Peter J, Osman, Narin

“…G protein coupled receptor (GPCR) signalling covers three major mechanisms. GPCR agonist engagement allows for the G proteins to bind to the receptor leading…”
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Hyperelongated biglycan: the surreptitious initiator of atherosclerosis by Little, Peter J, Osman, Narin, O'Brien, Kevin D

“…To outline a role for the dermatan sulfate proteoglycan biglycan and specifically its growth factor modified form having elongated glycosaminoglycan chains as…”
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Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans by Osman, Narin, Zheng, Wenhua, Thach, Lyna, Al Gwairi, Othman, Little, Peter J.

“…Age-related macular degeneration (AMD) is a retinal disease evident after the age of 50 that damages the macula in the centre of retina. It leads to a loss of…”
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Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors by Kamato, Danielle, Burch, Micah L., Osman, Narin, Zheng, Wenhua, Little, Peter J.

“…Objectives  This review discusses the latest developments in G protein coupled receptor (GPCR) signalling related to the transactivation of cell surface…”
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Smad and p38 MAP Kinase-mediated Signaling of Proteoglycan Synthesis in Vascular Smooth Muscle by Dadlani, Harsha, Ballinger, Mandy L., Osman, Narin, Getachew, Robel, Little, Peter J.

“…Atherosclerosis is the underlying pathological process of most cardiovascular disease. A critical component of the “response to retention” hypothesis of…”
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Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo by Ballinger, Mandy L., Osman, Narin, Hashimura, Kazuhiko, Haan, Judy B. de, Jandeleit‐Dahm, Karin, Allen, Terri, Tannock, Lisa R., Rutledge, John C., Little, Peter J.

“…The ‘response to retention’ hypothesis of atherogenesis proposes that proteoglycans bind and retain low‐density lipoproteins (LDL) in the vessel wall…”
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Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells by Little, Peter J., Rostam, Muhamad Ashraf, Piva, Terrence J., Getachew, Robel, Kamato, Danielle, Guidone, Daniel, Ballinger, Mandy L., Zheng, Wenhua, Osman, Narin

“…Objectives Suramin is a polysulfonated naphthylurea with antiparasitic and potential antineoplastic activity. Suramin's pharmacological actions, which have not…”
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Gaq proteins: molecular pharmacology and therapeutic potential by Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret, Little, Peter J.

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Endothelin-1 actions on vascular smooth muscle cell functions as a target for the prevention of atherosclerosis by Little, Peter J, Ivey, Melanie E, Osman, Narin

“…The formation and progression of atherosclerotic plaques followed by rupture, thrombus formation and vessel blockage leads to ischemic tissue damage and the…”
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Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis by Little, Peter J, Ballinger, Mandy L, Osman, Narin

“…Atherosclerosis is the underlying pathology of most cardiovascular disease and it represents the major cause of premature death in modern societies. Current…”
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Combined transgenic expression of α-galactosidase and α1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galα(1,3)Gal by Osman, Narin, McKenzie, Ian F. C., Ostenried, Karen, Ioannou, Yiannis A., Desnick, Robert J., Sandrin, Mauro S.

“…Hyperacute rejection of pig organs by humans involves the interaction of Galα(1,3)Gal with antibodies and complement. Strategies to reduce the amount of…”
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