Search Results - "Osman, Essam Eldin A."

Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors by Eldin A. Osman, Essam, Hanafy, Noura S., George, Riham F., El-Moghazy, Samir M.

“…[Display omitted] •Barbituric acid derivatives were designed as non-classical PARP1 inhibitors.•The synthesized compounds revealed nanomolar inhibition against…”
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Synthesis and biological evaluation of novel xanthine derivatives as potential apoptotic antitumor agents by Hisham, Mohamed, Youssif, Bahaa G.M., Osman, Essam Eldin A., Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…A series of novel xanthine/NO donor hybrids containing 1,3,8-trisubstituted or 1,8-disubstituted xanthine derivatives were designed and synthesized. The…”
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Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis by Elanany, Mohamed A., Osman, Essam Eldin A., Gedawy, Ehab Mohamed, Abou-Seri, Sahar M.

“…To exploit the advantageous properties of approved drugs to hasten anticancer drug discovery, we designed and synthesized a series of fluoroquinolone (FQ)…”
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5-Chlorobenzofuran-2-carboxamides: From allosteric CB1 modulators to potential apoptotic antitumor agents by Youssif, Bahaa G.M., Mohamed, Ashraf M., Osman, Essam Eldin A., Abou-Ghadir, Ola F., Elnaggar, Dina H., Abdelrahman, Mostafa H., Treamblu, Laurent, Gomaa, Hesham A.M.

“…Cannabinoids as THC and the CB1 allosteric modulator CBD were reported to have antiproliferative activities with no reports for other CB1 allosteric modulators…”
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“Turn-On” Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer’s Disease: Rational Design, Synthesis, and Molecular Docking by Elbatrawy, Ahmed A, Hyeon, Seung Jae, Yue, Nan, Osman, Essam Eldin A, Choi, Seung Hyeo, Lim, Sungsu, Kim, Yun Kyung, Ryu, Hoon, Cui, Mengchao, Nam, Ghilsoo

“…Tau aggregation is believed to have a strong association with the level of cognitive deficits in Alzheimer’s disease (AD). Thus, optical brain imaging of tau…”
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Novel 3,6-Disubstituted Pyridazine Derivatives Targeting JNK1 Pathway: Scaffold Hopping and Hybridization-Based Design, Synthesis, Molecular Modeling, and In Vitro and In Vivo Anticancer Evaluation by Shaalan, Mai M., Osman, Essam Eldin A., Attia, Yasmeen M., Hammam, Olfat A., George, Riham F., Naguib, Bassem H.

“…A series of novel 3,6-disubstituted pyridazine derivatives were designed, synthesized, and biologically evaluated as preclinical anticancer candidates…”
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Ironing Out the Mechanism of gp130 Signaling by Osman, Essam Eldin A, Neamati, Nouri

“…gp130 functions as a shared signal-transducing subunit not only for interleukin (IL)-6 but also for eight other human cytokine receptor complexes. The IL-6…”
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Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors by Ahmed, Riham I., Osman, Essam Eldin A., Awadallah, Fadi M., El-Moghazy, Samir M.

“…New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace…”
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Why All the Fury over Furin? by Osman, Essam Eldin A, Rehemtulla, Alnawaz, Neamati, Nouri

“…Analysis of the SARS-CoV-2 sequence revealed a multibasic furin cleavage site at the S1/S2 boundary of the spike protein distinguishing this virus from…”
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Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer by Roy, Joyeeta, Kyani, Armita, Hanafi, Maha, Xu, Yibin, Takyi-Williams, John, Sun, Duxin, Osman, Essam Eldin A., Neamati, Nouri

“…Sigma 2 receptor (σ2R) is overexpressed in select cancers and is regarded as a biomarker for tumor proliferation. σ2R ligands are emerging as promising…”
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Analytical investigation of different mathematical approaches utilizing manipulation of ratio spectra by Osman, Essam Eldin A.

“…This work represents a comparative study of different approaches of manipulating ratio spectra, applied on a binary mixture of ciprofloxacin HCl and…”
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COVID-19: Living through Another Pandemic by Osman, Essam Eldin A, Toogood, Peter L, Neamati, Nouri

“…Novel beta-coronavirus SARS-CoV-2 is the pathogenic agent responsible for coronavirus disease-2019 (COVID-19), a globally pandemic infectious disease. Due to…”
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Design and synthesis of novel furan, furo[2,3-d]pyrimidine and furo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as potential VEGFR-2 inhibitors by Abd El-Mageed, Menna M.A., Eissa, Amal A.M., Farag, Awatef El-Said, Osman, Essam Eldin A.

“…[Display omitted] •New furan, furopyrimidine and furotriazolopyrimidine derivatives were synthesized as potential VEGFR-2 inhibitors.•Furopyrimidine 8b and…”
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Design, synthesis and docking studies of novel benzopyrone derivatives as anticonvulsants by Abd-Allah, Walaa Hamada, Osman, Essam Eldin A., Anwar, Mostafa Abd-El-Mohsen, Attia, Hanan Naeim, El Moghazy, Samir M.

“…[Display omitted] •Synthesis of novel benzopyrone derivatives as anticonvulsants.•In preliminary phase I screening, compound 6 exhibited the most potent Fig…”
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Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line by El-Moghazy, Samir M., George, Riham F., Osman, Essam Eldin A., Elbatrawy, Ahmed A., Kissova, Miroslava, Colombo, Ambra, Crespan, Emmanuele, Maga, Giovanni

“…Some novel 6-substituted pyrazolo[3,4-d]pyrimidines 4, 5, 6a-d, 7a-c, 8 and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidines 9a-c, 10a-c, 11, 12a,b, 13a-c and…”
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Design, synthesis and biological evaluation of some novel quinazolinone derivatives as potent apoptotic inducers by Nowar, Raghad M, A Osman, Essam Eldin, Abou-Seri, Sahar M, El Moghazy, Samir M, Abou El Ella, Dalal A

“…Novel quinazolinone and triazinoquinazolinone derivatives were designed and synthesized as apoptotic inducers. Most of the synthesized compounds showed…”
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Design and synthesis of novel 5-(4-chlorophenyl)furan derivatives with inhibitory activity on tubulin polymerization by Moussa, Shaimaa A, A Osman, Essam Eldin, Eid, Nahed M, Abou-Seri, Sahar M, El Moghazy, Samir M

“…Discovery of novel series of colchicine binding site inhibitors (CBSIs). Isoxazoline , pyrazoline and , cyclohexenone and or pyridine derivatives were…”
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