Search Results - "Oskarsson, Bjorn"

Clinical characteristics of a large cohort of US participants enrolled in the National Amyotrophic Lateral Sclerosis (ALS) Registry, 2010-2015 by Raymond, Jaime, Oskarsson, BjÖrn, Mehta, Paul, Horton, Kevin

“…Background: Amyotrophic lateral sclerosis (ALS) is a progressive fatal disease with a varying range of clinical characteristics. Objective: To describe the…”
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Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD by Tang, Xiaoqiang, Toro, Arturo, T G, Sahana, Gao, Junli, Chalk, Jessica, Oskarsson, Björn, Zhang, Ke

“…Ever since a GGGGCC hexanucleotide repeat expansion mutation in C9ORF72 was identified as the most common cause of familial amyotrophic lateral sclerosis (ALS)…”
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C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy by Cook, Casey N, Wu, Yanwei, Odeh, Hana M, Gendron, Tania F, Jansen-West, Karen, Del Rosso, Giulia, Yue, Mei, Jiang, Peizhou, Gomes, Edward, Tong, Jimei, Daughrity, Lillian M, Avendano, Nicole M, Castanedes-Casey, Monica, Shao, Wei, Oskarsson, Björn, Tomassy, Giulio S, McCampbell, Alexander, Rigo, Frank, Dickson, Dennis W, Shorter, James, Zhang, Yong-Jie, Petrucelli, Leonard

“…TAR DNA-binding protein 43 (TDP-43) inclusions are a pathological hallmark of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), including…”
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Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity by Zhang, Yong-Jie, Guo, Lin, Gonzales, Patrick K, Gendron, Tania F, Wu, Yanwei, Jansen-West, Karen, O'Raw, Aliesha D, Pickles, Sarah R, Prudencio, Mercedes, Carlomagno, Yari, Gachechiladze, Mariam A, Ludwig, Connor, Tian, Ruilin, Chew, Jeannie, DeTure, Michael, Lin, Wen-Lang, Tong, Jimei, Daughrity, Lillian M, Yue, Mei, Song, Yuping, Andersen, Jonathan W, Castanedes-Casey, Monica, Kurti, Aishe, Datta, Abhishek, Antognetti, Giovanna, McCampbell, Alexander, Rademakers, Rosa, Oskarsson, Björn, Dickson, Dennis W, Kampmann, Martin, Ward, Michael E, Fryer, John D, Link, Christopher D, Shorter, James, Petrucelli, Leonard

“…How hexanucleotide GGGGCC (G C ) repeat expansions in cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is not understood. We…”
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Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis by Zhang, Yong-Jie, Gendron, Tania F., Ebbert, Mark T. W., O’Raw, Aliesha D., Yue, Mei, Jansen-West, Karen, Zhang, Xu, Prudencio, Mercedes, Chew, Jeannie, Cook, Casey N., Daughrity, Lillian M., Tong, Jimei, Song, Yuping, Pickles, Sarah R., Castanedes-Casey, Monica, Kurti, Aishe, Rademakers, Rosa, Oskarsson, Bjorn, Dickson, Dennis W., Hu, Wenqian, Gitler, Aaron D., Fryer, John D., Petrucelli, Leonard

“…The major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a C9orf72 G 4 C 2 repeat expansion 1 , 2 . Proposed…”
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Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19 by Prudencio, Mercedes, Erben, Young, Marquez, Christopher P, Jansen-West, Karen R, Franco-Mesa, Camila, Heckman, Michael G, White, Launia J, Dunmore, Judith A, Cook, Casey N, Lilley, Meredith T, Song, Yuping, Harlow, Caroline F, Oskarsson, Björn, Nicholson, Katharine A, Wszolek, Zbigniew K, Hickson, LaTonya J, O'Horo, John C, Hoyne, Jonathan B, Gendron, Tania F, Meschia, James F, Petrucelli, Leonard

“…Brain imaging studies of patients with COVID-19 show evidence of macro- and microhemorrhagic lesions, multifocal white matter hyperintensities, and lesions…”
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Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial by Wainger, Brian J, Macklin, Eric A, Vucic, Steve, McIlduff, Courtney E, Paganoni, Sabrina, Maragakis, Nicholas J, Bedlack, Richard, Goyal, Namita A, Rutkove, Seward B, Lange, Dale J, Rivner, Michael H, Goutman, Stephen A, Ladha, Shafeeq S, Mauricio, Elizabeth A, Baloh, Robert H, Simmons, Zachary, Pothier, Lindsay, Kassis, Sylvia Baedorf, La, Thuong, Hall, Meghan, Evora, Armineuza, Klements, David, Hurtado, Aura, Pereira, Joao D, Koh, Joan, Celnik, Pablo A, Chaudhry, Vinay, Gable, Karissa, Juel, Vern C, Phielipp, Nicolas, Marei, Adel, Rosenquist, Peter, Meehan, Sean, Oskarsson, Björn, Lewis, Richard A, Kaur, Divpreet, Kiskinis, Evangelos, Woolf, Clifford J, Eggan, Kevin, Weiss, Michael D, Berry, James D, David, William S, Davila-Perez, Paula, Camprodon, Joan A, Pascual-Leone, Alvaro, Kiernan, Matthew C, Shefner, Jeremy M, Atassi, Nazem, Cudkowicz, Merit E

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor nervous system. Clinical studies have demonstrated cortical and…”
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Needs of persons living with ALS at home and their family caregivers: A scoping review by Young, Heather M., Kilaberia, Tina R., Whitney, Robin, Link, Benjamin M., Bell, Janice F., Tonkikh, Orly, Famula, Jessica, Oskarsson, Björn

“…Introduction/Aims Most persons with amyotrophic lateral sclerosis (ALS) live at home with support of family caregivers, with escalating complexity of care over…”
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Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration by Shao, Wei, Todd, Tiffany W, Wu, Yanwei, Jones, Caroline Y, Tong, Jimei, Jansen-West, Karen, Daughrity, Lillian M, Park, Jinyoung, Koike, Yuka, Kurti, Aishe, Yue, Mei, Castanedes-Casey, Monica, Del Rosso, Giulia, Dunmore, Judith A, Zanetti Alepuz, Desiree, Oskarsson, Björn, Dickson, Dennis W, Cook, Casey N, Prudencio, Mercedes, Gendron, Tania F, Fryer, John D, Zhang, Yong-Jie, Petrucelli, Leonard

“…Frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS) are associated with both a repeat expansion in the gene and mutations in the TANK-binding…”
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Cortical excitability threshold can be increased by the AMPA blocker Perampanel in amyotrophic lateral sclerosis by Oskarsson, Björn, Mauricio, Elizabeth A., Shah, Jaimin S., Li, Zhuo, Rogawski, Michael A.

“…Introduction/Aims Cortical hyperexcitability is a feature of amyotrophic lateral sclerosis (ALS) and cortical excitability can be measured using transcranial…”
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The relationship between ventilatory function and cognitive and behavioral impairment in ALS by Shah, Jaimin S., Pedraza, Otto, Festic, Emir, Oskarsson, Björn

“…Objective: To study the association between ventilatory function and cognitive and behavioral impairment in ALS patients accounting for the effects of…”
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(−)‐Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy by McDonald, Craig M., Ramirez‐Sanchez, Israel, Oskarsson, Björn, Joyce, Nanette, Aguilar, Candace, Nicorici, Alina, Dayan, Jonathan, Goude, Erica, Abresch, R. Ted, Villarreal, Francisco, Ceballos, Guillermo, Perkins, Guy, Dugar, Sundeep, Schreiner, George, Henricson, Erik K.

“…Introduction We conducted an open‐label study to examine the effects of the flavonoid (−)‐epicatechin in seven ambulatory adult patients with Becker muscular…”
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Paravertebral block for radiologically inserted gastrostomy tube placement in amyotrophic lateral sclerosis by Porter, Steven B., McClain, Robert L., Robards, Christopher B., Paz‐Fumagalli, Ricardo, Clendenen, Steven R., Logvinov, Ilana I., Hex, Karina O., Palmucci, Carla, Oskarsson, Björn E.

“…Introduction Radiologically inserted gastrostomy (RIG) placement in patients with amyotrophic lateral sclerosis (ALS) carries risks related to periprocedural…”
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Analysis of the US Safety Data for Edaravone (Radicava®) From the Third Year After Launch by Genge, Angela, Brooks, Benjamin Rix, Oskarsson, Björn, Kalin, Alexander, Ji, Ming, Apple, Stephen, Bower, Laura

“…Background Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease with no curative therapies. Edaravone (Radicava ® ) (Mitsubishi…”
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Myasthenia gravis exacerbation after discontinuing mycophenolate: A single-center cohort study by Oskarsson, Björn, Rocke, David M, Dengel, Karsten, Richman, David P

“…OBJECTIVE:To determine whether discontinuation or marked reduction of mycophenolate mofetil (MMF) in patients with myasthenia gravis (MG) causes MG…”
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Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD by Pineda, S Sebastian, Lee, Hyeseung, Ulloa-Navas, Maria J, Linville, Raleigh M, Garcia, Francisco J, Galani, Kyriakitsa, Engelberg-Cook, Erica, Castanedes, Monica C, Fitzwalter, Brent E, Pregent, Luc J, Gardashli, Mahammad E, DeTure, Michael, Vera-Garcia, Diana V, Hucke, Andre T S, Oskarsson, Bjorn E, Murray, Melissa E, Dickson, Dennis W, Heiman, Myriam, Belzil, Veronique V, Kellis, Manolis

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) share many clinical, pathological, and genetic features, but a detailed…”
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Addressing the Role of Edaravone in the Management of Amyotrophic Lateral Sclerosis and Gaps in Care and Access: Expert Panel Recommendations by Barrington, Christina J, Burruano, Martin, Carney, Caroline, Choi, Joseph, Januska, Jeff, Lachuk, Lester, Oskarsson, Björn, Rodriguez, Carly, Speicher, Lindsay, Tereso, Gary

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A novel muscle cramp scale (MCS) in amyotrophic lateral sclerosis (ALS) by Mitsumoto, Hiroshi, Chiuzan, Codruta, Gilmore, Madison, Zhang, Yuan, Ibagon, Camila, McHale, Brittany, Hupf, Jonathan, Oskarsson, BjÖrn

“…Objective: To develop a novel muscle cramp scale (MCS) to assess frequency, severity and clinically meaningful information related to cramps among patients…”
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National Study of Muscle Cramps in ALS in the USA by Stephens, Helen E., Joyce, Nanette C., Oskarsson, Björn

“…The objective of this study was to describe muscle cramps in an US sample of amyotrophic lateral sclerosis (ALS) patients. Utilizing an anonymous web based…”
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Abundant transcriptomic alterations in the human cerebellum of patients with a C9orf72 repeat expansion by Udine, Evan, DeJesus-Hernandez, Mariely, Tian, Shulan, das Neves, Sofia Pereira, Crook, Richard, Finch, NiCole A., Baker, Matthew C., Pottier, Cyril, Graff-Radford, Neill R., Boeve, Bradley F., Petersen, Ronald C., Knopman, David S., Josephs, Keith A., Oskarsson, Björn, Da Mesquita, Sandro, Petrucelli, Leonard, Gendron, Tania F., Dickson, Dennis W., Rademakers, Rosa, van Blitterswijk, Marka

“…The most prominent genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) is a repeat expansion in the gene…”
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