Search Results - "Oskam, Nienke"

Factors affecting IgG4-mediated complement activation by Oskam, Nienke, Damelang, Timon, Streutker, Marij, Ooijevaar-de Heer, Pleuni, Nouta, Jan, Koeleman, Carolien, Van Coillie, Julie, Wuhrer, Manfred, Vidarsson, Gestur, Rispens, Theo

“…Of the four human immunoglobulin G (IgG) subclasses, IgG4 is considered the least inflammatory, in part because it poorly activates the complement system…”
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Glucocorticoid-Induced Attenuation of the Inflammatory Response in Zebrafish by Chatzopoulou, Antonia, Heijmans, Jeroen P. M, Burgerhout, Erik, Oskam, Nienke, Spaink, Herman P, Meijer, Annemarie H, Schaaf, Marcel J. M

“…Glucocorticoids are steroid hormones that are secreted upon stress. Their effects are mediated by the glucocorticoid receptor, which acts as a transcription…”
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Next-generation rheumatoid factor assay provides improved predictive power for the development of arthritis in patients at risk by Oskam, Nienke, Ooijevaar-de Heer, Pleuni, Kos, Dorien, van Boheemen, Laurette, van Schaardenburg, Dirkjan, Wolbink, Gertjan, Rispens, Theo

“…ObjectiveRheumatoid arthritis (RA) is characterised by the presence of autoantibodies, among which those targeting the constant region of immunoglobulin G…”
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Longitudinal rheumatoid factor autoantibody responses after SARS-CoV-2 vaccination or infection by Keijzer, Sofie, Oskam, Nienke, Ooijevaar-de Heer, Pleuni, Steenhuis, Maurice, Keijser, Jim B D, Wieske, Luuk, van Dam, Koos P J, Stalman, Eileen W, Kummer, Laura Y L, Boekel, Laura, Kuijpers, Taco W, Ten Brinke, Anja, van Ham, S Marieke, Eftimov, Filip, Tas, Sander W, Wolbink, Gerrit J, Rispens, Theo

“…Rheumatoid factors (RFs) are autoantibodies that target the Fc region of IgG, and are found in patients with rheumatic diseases as well as in the healthy…”
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The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation by Boer, Esther CW, Thielen, Astrid JF, Langereis, Jeroen D, Kamp, Angela, Brouwer, Mieke C, Oskam, Nienke, Jongsma, Marlieke L, Baral, April J, Spaapen, Robbert M, Zeerleder, Sacha, Vidarsson, Gestur, Rispens, Theo, Wouters, Diana, Pouw, Richard B, Jongerius, Ilse

“…Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed…”
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Rheumatoid factor autoantibody repertoire profiling reveals distinct binding epitopes in health and autoimmunity by Oskam, Nienke, Ooijevaar-De Heer, Pleuni, Kos, Dorien, Jeremiasse, Jorn, van Boheemen, Laurette, Verstappen, Gwenny M, Kroese, Frans G M, van Schaardenburg, Dirkjan, Wolbink, Gertjan, Rispens, Theo

“…Rheumatoid factors (RF) are one of the hallmark autoantibodies characteristic of rheumatoid arthritis (RA), and are frequently observed in other diseases and…”
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At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity by Oskam, Nienke, Ooijevaar-de Heer, Pleuni, Derksen, Ninotska I L, Kruithof, Simone, de Taeye, Steven W, Vidarsson, Gestur, Reijm, Sanne, Kissel, Theresa, Toes, René E M, Rispens, Theo

“…IgM is secreted as a pentameric polymer containing a peptide called the joining chain (J chain). However, integration of the J chain is not required for IgM…”
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Identification of Clinically and Pathophysiologically Relevant Rheumatoid Factor Epitopes by Engineered IgG Targets by Falkenburg, Willem J. J., Oskam, Nienke, Koers, Jana, Boheemen, Laurette, Ooijevaar‐de Heer, Pleuni, Verstappen, Gwenny M., Bootsma, Hendrika, Kroese, Frans G. M., Schaardenburg, Dirkjan, Wolbink, Gertjan, Rispens, Theo

“…Objective Rheumatoid factors (RFs), which are anti‐IgG autoantibodies strongly associated with rheumatoid arthritis (RA), are also found in other diseases and…”
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CD5L is a canonical component of circulatory IgM by Oskam, Nienke, den Boer, Maurits A, Lukassen, Marie V, Ooijevaar-de Heer, Pleuni, Veth, Tim S, van Mierlo, Gerard, Lai, Szu-Hsueh, Derksen, Ninotska I L, Yin, Victor, Streutker, Marij, Franc, Vojtech, Šiborová, Marta, Damen, Mirjam J A, Kos, Dorien, Barendregt, Arjan, Bondt, Albert, van Goudoever, Johannes B, de Haas, Carla J C, Aerts, Piet C, Muts, Remy M, Rooijakkers, Suzan H M, Vidarsson, Gestur, Rispens, Theo, Heck, Albert J R

“…Immunoglobulin M (IgM) is an evolutionary conserved key component of humoral immunity, and the first antibody isotype to emerge during an immune response. IgM…”
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