Search Results - "Osipov, V. N."

Phosphorylation of Tyrosine and Tyr-Thr-Lys Tripeptide with Cyclohexylmethyl- and (Deuteromethyl)phosphonochloridates by Rodin, I. A., Baygildiev, T. M., Krylov, V. I., Osipov, V. N., Krylov, I. I., Yashkir, V. A., Rybalchenko, I. V.

“…Methods for phosphorylation of tyrosine and Tyr-Thr-Lys tripeptide with cyclohexylmethyl(deuteromethyl)phosphonochloridates have been developed. These products…”
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Influence of Modifying Elements on the Structure and Mechanical Properties of Casting Al–Si Alloys by Osipov, V. N.

“…The state of scientific research on the modification of aluminum-silicon (Al–Si) alloy with strontium, sodium, phosphorus, which are widely employed in…”
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Dislocation anelasticity in Al–Si/Ge alloys obtained by directed solidification by Nikanorov, S.P., Kardashev, B.K., Osipov, V.N.

“…Young’s modulus defect, internal friction (logarithmic decrement), and flow stress at a constant anelastic strain measured at frequency about100 kHz at…”
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Preparation of 155Tb-labeled short somatostatin analog by Moiseeva, A. N., Aliev, R. A., Osipov, V. N., Khachatryan, D. S.

“…The complex of the short somatostatin analog, DOTA—Phe—D-Trp—Lys—Thr—OMe (DOTA is 1,4,7,10-tetrraazacyclododecane-1,4,7,10-tetraacetic acid), with the…”
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Influence of the Rate of Directional Crystallization and Silicon Content on the Structure and Strength of the Al–Si–Cu Alloy by Nikanorov, S. P., Osipov, V. N., Timashov, R. B., Chikiryaka, A. V.

“…The structure and strength of Al x Si–2 wt % Cu ( x = 15, 17, and 20 wt %) alloys obtained by directional solidification at a rate of 0.1 and 0.8 mm/s are…”
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Synthesis of precursors for obtaining targeted radiopharmaceuticals based on short peptides, analogs of the hormone somatostatin by Khachatryan, D. S., Kolotaev, A. V., Malyutina, E. R., Osipov, V. N.

“…New precursors with various linkers for the construction of targeted radiopharmaceuticals based on a pharmacophore fragment of the hormone somatostatin,…”
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HT_PREDICT: a machine learning-based computational open-source tool for screening HDAC6 inhibitors by Tinkov, O.V., Osipov, V.N., Kolotaev, A.V., Khachatryan, D.S., Grigorev, V.Y.

“…Histone deacetylase 6 (HDAC6) is a promising drug target for the treatment of human diseases such as cancer, neurodegenerative diseases (in particular,…”
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HDAC1 PREDICTOR: a simple and transparent application for virtual screening of histone deacetylase 1 inhibitors by Tinkov, O.V., Grigorev, V.Y., Grigoreva, L.D., Osipov, V.N.

“…Histone deacetylases play an important role in regulating gene expression by modifying histones and changing chromatin conformation. HDAC dysregulation is…”
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HDAC6 detector: online application for evaluating compounds as potential histone deacetylase 6 inhibitors by Tinkov, O.V., Grigorev, V.Y., Grigoreva, L.D., Osipov, V.N., Kolotaev, A.V., Khachatryan, D.S.

“…The HDAC6 (histone deacetylase 6) enzyme plays a key role in many biological processes, including cell division, apoptosis, and immune response. To date, HDAC6…”
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Wear and Coefficient of Friction of a Supermodified Hypereutectic Aluminum–Silicon Alloy by Osipov, V. N., Fadin, Yu. A., Nikanorov, S. P.

“…The friction coefficient and the wear of a hypereutectic aluminum alloy with 15 wt % silicon and a supermodified eutectic structure without primary silicon…”
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QSAR analysis and experimental evaluation of new quinazoline-containing hydroxamic acids as histone deacetylase 6 inhibitors by Tinkov, O.V., Grigorev, V.Y., Grigoreva, L.D., Osipov, V.N., Kolotaev, A.V., Khachatryan, D.S.

“…Histone deacetylase inhibitors represent the most important class of drugs for the treatment of human cancer and other diseases due to their influence on cell…”
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3-Hydroxyquinazoline Derivatives, Analogues of Erastin, Induce Ferroptosis in Colorectal Cancer Cells by Osipov, V. N., Vartanyan, A. A., Khochenkov, D. A., Gusev, D. V., Fateenkova, O. V., Khachatryan, D. S., Borisova, L. M.

“…Objective: In recent years, significant progress has been achieved in the treatment of patients with colorectal cancer, but in most cases, treatment is…”
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Calculation methodology of the energy indicators of an self-contained energy complex including gas turbine plants, wind-driven power plant and electric storage cell by Nikolaev, Y. E., Osipov, V. N., Ignatov, V. Y.

“…To supply small cities with electric and thermal energy it is proposed to create selfcontained energy complex based on gas turbine plants (GTP), wind…”
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3-Hydroxyquinazoline derivatives, analogues of erastin, induced ferroptosis in breast cancer cells by Borisova, L. M., Osipov, V. N., Golubeva, I. S., Kiseleva, M. P., Hochenkov, D. A., Vartanyan, A. A.

“…Introduction. Early malignant tumor detection programs have significantly increased the survival rate of breast cancer patients but the results of drug therapy…”
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Inelasticity and Nanostructured Dislocation Deformation of Aluminum–Silicon Alloy with a Supermodified Eutectic Structure by Nikanorov, S. P., Kardashev, B. K., Osipov, V. N., Kaminskii, V. V., Sharenkova, N. V.

“…Young’s modulus and the logarithmic decrement of oscillations at a frequency of ~100 kHz as well as the subgrain size and residual stresses in the strontium…”
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Mechanisms of the Cytotoxic Action of Novel Cyclic Hydroxamic Acids by Neganova, M. E., Aleksandrova, Yu. R., Pukhov, S. A., Klochkov, S. G., Osipov, V. N.

“…— Cyclic hydroxamic acids (CHAs) based on quinazoline-4(3H)-one and dihydroquinazoline-4(1H)-one have been synthesized. The antioxidant and iron-chelating…”
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Effect of Derivatives of Hydroxamic Acids on Vasculogenic Mimicry by Vartanian, A. A., Khochenkov, D. A., Khochenkova, Yu. A., Machkova, Yu. S., Khachatryan, D. S., Kolotaev, A. V., Balaev, A. N., Ohmanovich, K. A., Osipov, V. N.

“…— Vasculogenic mimicry, the formation of vascular channels lined with tumor cells of a highly malignant phenotype, is currently considered as an additional…”
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Synthetic Peptide Analogs of Somatostatin: Trends in the Synthesis of and Prospects in the Search for New Anticancer Drugs by Balaev, A. N., Osipov, V. N., Khachatryan, D. S.

“…The native hormone somatostatin plays an important role in vivo by acting on multiple targets via a family of five receptors to produce a broad spectrum of…”
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Pentapeptide analogs of somatostatin containing a thiazolidine fragment: synthesis and cytotoxic activity by Balaev, A. N., Osipov, V. N., Okhmanovich, K. A., Ruchko, E. A., Baryshnikova, M. A., Khachatryan, D. S.

“…Pentapeptide analogs of somatostatin containing an ( R )-1,3-thiazolidine fragment (Thz) of the general formula X—Thz—Phe—D-Trp—Lys(Y)—Thr—Z were synthesized…”
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Synthesis and cytotoxic activity of Boc-protected pentapeptide amide analogs of somatostatin by Balaev, A. N., Osipov, V. N., Okhmanovich, K. A., Ruchko, E. A., Kolotaev, A. V., Khachatryan, D. S.

“…New Boc-protected pentapeptide amides of the general formula Boc—Cys(Boc)—Phe— d -Trp—Lys(Boc)—Thr—NHR, which are analogs of the natural hormone somatostatin,…”
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