Search Results - "Oshima, Keiko"

A novel T cell-redirecting anti-GPRC5D × CD3 bispecific antibody with potent antitumor activity in multiple myeloma preclinical models by Tomita, Urara, Ishimoto, Yoko, Ri, Masaki, Kawase, Yumi, Hizukuri, Yoshiyuki, Maru, Chikako, Nanai, Kayoko, Nakamura, Ryuichi, Nakayama, Makiko, Oguchi-Oshima, Keiko, Sumi, Hiroyuki, Ohtsuka, Toshiaki, Iida, Shinsuke, Agatsuma, Toshinori

“…G-protein-coupled receptor class 5 member D (GPRC5D) is detected in malignant plasma cells in approximately 90% of patients diagnosed with multiple myeloma…”
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Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist by Nakamura, Tsuyoshi, Asano, Masayoshi, Sekiguchi, Yukiko, Mizuno, Yumiko, Tamaki, Kazuhiko, Kimura, Takako, Nara, Futoshi, Kawase, Yumi, Shimozato, Takaichi, Doi, Hiromi, Kagari, Takashi, Tomisato, Wataru, Inoue, Ryotaku, Nagasaki, Miyuki, Yuita, Hiroshi, Oguchi-Oshima, Keiko, Kaneko, Reina, Watanabe, Nobuaki, Abe, Yasuyuki, Nishi, Takahide

“…A description of the discovery process of CS-2100, a potent, orally active, S1P3-sparing S1P1 agonist has been provided. Its 4-ethyl thiophene structure…”
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Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist by Nishi, Takahide, Miyazaki, Shojiro, Takemoto, Toshiyasu, Suzuki, Keisuke, Iio, Yukiko, Nakajima, Katsuyoshi, Ohnuki, Takashi, Kawase, Yumi, Nara, Futoshi, Inaba, Shinichi, Izumi, Takashi, Yuita, Hiroshi, Oshima, Keiko, Doi, Hiromi, Inoue, Ryotaku, Tomisato, Wataru, Kagari, Takashi, Shimozato, Takaichi

“…CS-0777 (3) is phosphorylated in vivo, and the phosphate of CS-0777 (CS-0777-P) (4) acts as a selective S1P receptor-1 (S1P1) modulator. We report herein the…”
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Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists by Asano, Masayoshi, Nakamura, Tsuyoshi, Sekiguchi, Yukiko, Mizuno, Yumiko, Yamaguchi, Takahiro, Tamaki, Kazuhiko, Shimozato, Takaichi, Doi-Komuro, Hiromi, Kagari, Takashi, Tomisato, Wataru, Inoue, Ryotaku, Yuita, Hiroshi, Oguchi-Oshima, Keiko, Kaneko, Reina, Nara, Futoshi, Kawase, Yumi, Masubuchi, Noriko, Nakayama, Shintaro, Koga, Tetsufumi, Namba, Eiko, Nasu, Hatsumi, Nishi, Takahide

“…A series of 1,3-thiazole derivatives were synthesized as potent, orally bioavailable S1P3-sparing S1P1 agonists. One of them, 24c, exhibited favorable efficacy…”
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Synthesis and evaluation of CS-2100, a potent, orally active and S1P3- sparing S1P1 agonist by Nakamura, Tsuyoshi, Asano, Masayoshi, Sekiguchi, Yukiko, Mizuno, Yumiko, Tamaki, Kazuhiko, Nara, Futoshi, Kawase, Yumi, Yabe, Yoshiyuki, Nakai, Daisuke, Kamiyama, Emi, Urasaki-Kaneno, Yoko, Shimozato, Takaichi, Doi-Komuro, Hiromi, Kagari, Takashi, Tomisato, Wataru, Inoue, Ryotaku, Nagasaki, Miyuki, Yuita, Hiroshi, Oguchi-Oshima, Keiko, Kaneko, Reina, Nishi, Takahide

“…Modulators of sphingosine phosphate receptor-1 (S1P1) have recently been focused as a suppressant of autoimmunity. We have discovered a 4-ethylthiophene-based…”
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Discovery of CS-0777: A Potent, Selective, and Orally Active S1P 1 Agonist by Nishi, Takahide, Miyazaki, Shojiro, Takemoto, Toshiyasu, Suzuki, Keisuke, Iio, Yukiko, Nakajima, Katsuyoshi, Ohnuki, Takashi, Kawase, Yumi, Nara, Futoshi, Inaba, Shinichi, Izumi, Takashi, Yuita, Hiroshi, Oshima, Keiko, Doi, Hiromi, Inoue, Ryotaku, Tomisato, Wataru, Kagari, Takashi, Shimozato, Takaichi

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Evaluation of species difference in peripheral lymphocyte reduction effect of CS-0777, a sphingosine 1-phosphate receptor modulator, based on a pharmacokinetic/pharmacodynamic model analysis by Inaba, Shin-ichi, Goto, Maki, Tanaka-takanaka, Kaoru, Tanaka, Hisako, Tomisato, Wataru, Yuita, Hiroshi, Doi-Komuro, Hiromi, Inoue, Ryotaku, Oshima, Keiko, Kagari, Takashi, Shimozato, Takaichi, Izumi, Takashi

“…Pharmacokinetic (PK) and pharmacodynamic (PD) modeling was conducted for the reduction of peripheral lymphocytes after oral administration of CS‐0777 to…”
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Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist by Nakamura, Tsuyoshi, Asano, Masayoshi, Sekiguchi, Yukiko, Mizuno, Yumiko, Tamaki, Kazuhiko, Nara, Futoshi, Kawase, Yumi, Yabe, Yoshiyuki, Nakai, Daisuke, Kamiyama, Emi, Urasaki-Kaneno, Yoko, Shimozato, Takaichi, Doi-Komuro, Hiromi, Kagari, Takashi, Tomisato, Wataru, Inoue, Ryotaku, Nagasaki, Miyuki, Yuita, Hiroshi, Oguchi-Oshima, Keiko, Kaneko, Reina, Nishi, Takahide

“…Modulators of sphingosine phosphate receptor-1 (S1P(1)) have recently been focused as a suppressant of autoimmunity. We have discovered a…”
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