Search Results - "Osherov, Nir"

Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic Target by Osherov, Nir, Ben-Ami, Ronen

“…The ensuing inflammatory angiogenic response facilitates the migration of leukocytes to infected tissue and wound repair. [...]an emerging concept links…”
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The top three areas of basic research on Aspergillus fumigatus in 2011 by Osherov, Nir

“…Over 450 peer‐reviewed papers containing the keyword Aspergillus fumigatus were published in 2011. Although this method may be an impossible task, I have…”
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The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target by Binder, Jasmin, Shadkchan, Yana, Osherov, Nir, Krappmann, Sven

“…The identification of cellular targets for antifungal compounds is a cornerstone for the development of novel antimycotics, for which a significant need exists…”
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Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT by Charpak-Amikam, Yoav, Lapidus, Tom, Isaacson, Batya, Duev-Cohen, Alexandra, Levinson, Tal, Elbaz, Adi, Levi-Schaffer, Francesca, Osherov, Nir, Bachrach, Gilad, Hoyer, Lois L., Korem, Maya, Ben-Ami, Ronen, Mandelboim, Ofer

“…Candida albicans is the most common fungal pathogen and a prevalent cause of deadly bloodstream infections. Better understanding of the immune response against…”
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Vitamin Biosynthesis as an Antifungal Target by Meir, Zohar, Osherov, Nir

“…The large increase in the population of immunosuppressed patients, coupled with the limited efficacy of existing antifungals and rising resistance toward them,…”
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Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus by Raffa, Nicholas, Osherov, Nir, Keller, Nancy P

“…Copper is an essential micronutrient for the opportunistic human pathogen, . Maintaining copper homeostasis is critical for survival and pathogenesis…”
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Fungal Priming: Prepare or Perish by Harish, Ety, Osherov, Nir

“…Priming (also referred to as acclimation, acquired stress resistance, adaptive response, or cross-protection) is defined as an exposure of an organism to mild…”
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Efficient Generation of Multiple Seamless Point Mutations Conferring Triazole Resistance in Aspergillus fumigatus by Handelman, Mariana, Osherov, Nir

“…is a common human fungal pathogen that can cause a range of diseases. Triazoles are used to treat infections, but resistance is increasing due to mutations in…”
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Experimental and in-host evolution of triazole resistance in human pathogenic fungi by Handelman, Mariana, Osherov, Nir

“…The leading fungal pathogens causing systemic infections in humans are Candida spp., Aspergillus fumigatus , and Cryptococcus neoformans . The major class of…”
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The activating receptor NKG2D is an anti-fungal pattern recognition receptor by Charpak-Amikam, Yoav, Kournos, Mark, Kotzur, Rebecca, Isaacson, Batya, Bagad Brenner, Tal, Gomez-Cesar, Elidet, Abou-Kandil, Ammar, Ben-Ami, Ronen, Korem, Maya, Guerra, Nadia, Osherov, Nir, Mandelboim, Ofer

“…NKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8 + T cells. The known role of NKG2D is to recognize…”
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Correction: Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic Target by Osherov, Nir, Ben-Ami, Ronen

“…[This corrects the article DOI: 10.1371/journal.ppat.1005479.]…”
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Identification and Analysis of Fungal-Specific Regions in the Aspergillus fumigatus Cu Exporter CrpA That Are Essential for Cu Resistance but Not for Virulence by Werner, Hila, Abou Kandil, Ammar, Meir, Zohar, Malis, Yehonathan, Shadkchan, Yona, Masrati, Gal, Ben-Tal, Nir, Hirschberg, Koret, Osherov, Nir

“…The opportunistic fungus is the primary invasive mold pathogen in humans, and is responsible for an estimated 200,000 yearly deaths worldwide. Most fatalities…”
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Uptake of the Siderophore Triacetylfusarinine C, but Not Fusarinine C, Is Crucial for Virulence of Aspergillus fumigatus by Aguiar, Mario, Orasch, Thomas, Shadkchan, Yana, Caballero, Patricia, Pfister, Joachim, Sastré-Velásquez, Luis Enrique, Gsaller, Fabio, Decristoforo, Clemens, Osherov, Nir, Haas, Hubertus

“…Siderophores play an important role in fungal virulence, serving as trackers for imaging and as biomarkers of fungal infections. However, siderophore uptake is…”
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Transcription Factor PrtT Controls Expression of Multiple Secreted Proteases in the Human Pathogenic Mold Aspergillus fumigatus by Sharon, Haim, Hagag, Shelly, Osherov, Nir

“…The role of secreted proteases in the virulence of the pathogenic fungus Aspergillus fumigatus remains controversial. Recently, the Aspergillus niger…”
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Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus by Dietl, Anna-Maria, Meir, Zohar, Shadkchan, Yona, Osherov, Nir, Haas, Hubertus

“…Background: Aspergillus fumigatus is the most prevalent airborne fungal pathogen, causing invasive fungal infections mainly in immunosuppressed individuals…”
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Horizontal Gene Transfer of Triazole Resistance in Aspergillus fumigatus by Morogovsky, Alma, Handelman, Mariana, Abou Kandil, Ammar, Shadkchan, Yona, Osherov, Nir

“…Aspergillus fumigatus is the primary mold pathogen in humans. It can cause a wide range of diseases in humans, with high mortality rates in immunocompromised…”
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Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense by Wiemann, Philipp, Perevitsky, Adi, Lim, Fang Yun, Shadkchan, Yana, Knox, Benjamin P., Landero Figueora, Julio A., Choera, Tsokyi, Niu, Mengyao, Steinberger, Andrew J., Wüthrich, Marcel, Idol, Rachel A., Klein, Bruce S., Dinauer, Mary C., Huttenlocher, Anna, Osherov, Nir, Keller, Nancy P.

“…The Fenton-chemistry-generating properties of copper ions are considered a potent phagolysosome defense against pathogenic microbes, yet our understanding of…”
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Mechanisms of Bacterial (Serratia marcescens) Attachment to, Migration along, and Killing of Fungal Hyphae by Hover, Tal, Maya, Tal, Ron, Sapir, Sandovsky, Hani, Shadkchan, Yana, Kijner, Nitzan, Mitiagin, Yulia, Fichtman, Boris, Harel, Amnon, Shanks, Robert M Q, Bruna, Roberto E, García-Véscovi, Eleonora, Osherov, Nir

“…We have found a remarkable capacity for the ubiquitous Gram-negative rod bacterium Serratia marcescens to migrate along and kill the mycelia of zygomycete…”
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Evolution of the pathogenic mold Aspergillus fumigatus on high copper levels identifies novel resistance genes by Handelman, Mariana, Meir, Zohar, Shadkchan, Yona, Abo Kandil, Ammar, Amano, Orin, Mariscal, Melani, López-Berges, Manuel Sánchez, Osherov, Nir

“…is the leading cause of severe mold infections in immunocompromised patients. This common fungus possesses innate attributes that allow it to evade the immune…”
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Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence by Vaknin, Yakir, Hillmann, Falk, Iannitti, Rossana, Ben Baruch, Netali, Sandovsky-Losica, Hana, Shadkchan, Yona, Romani, Luigina, Brakhage, Axel, Kniemeyer, Olaf, Osherov, Nir

“…Aspergillus fumigatus is the most common pathogenic mold infecting humans and a significant cause of morbidity and mortality in immunocompromised patients. In…”
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