Search Results - "Osherov, N"

Aspergillus fumigatus and aspergillosis: From basics to clinics by Arastehfar, A., Carvalho, A., Houbraken, J., Lombardi, L., Garcia-Rubio, R., Jenks, J.D., Rivero-Menendez, O., Aljohani, R., Jacobsen, I.D., Berman, J., Osherov, N., Hedayati, M.T., Ilkit, M., Armstrong-James, D., Gabaldón, T., Meletiadis, J., Kostrzewa, M., Pan, W., Lass-Flörl, C., Perlin, D.S., Hoenigl, M.

“…The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by causing numerous invasive infections and a notable mortality in humans,…”
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DWI Hyperintensity in the Fornix Fimbria on MRI in Children by Rootman, M S, Kornreich, L, Osherov, A N, Konen, O

“…The fornix-fimbria complex is mainly involved in emotions and memory. In brain MR imaging studies of young children, we have occasionally noted DWI…”
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Aspergillus strain typing in the genomics era by Klaassen, C.H.W., Osherov, N.

“…Multiple reasons may justify a need for strain typing purposes, but the most common reason is to delineate the epidemiological relationships between isolates…”
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Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins by Osherov, N., Gazit, A., Gilon, C., Levitzki, A.

“…The HER2 (neu/erb-B2) proto-oncogene codes for a transmembrane receptor with tyrosine kinase activity and with high homology to the EGF receptor (HER1). The…”
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Overexpression of Sbe2p, a Golgi Protein, Results in Resistance to Caspofungin in Saccharomyces cerevisiae by OSHEROY, Nir, MAY, Gregory S, ALBERT, Nathaniel D, KONTOYIANNIS, D. P

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Aspergillus nidulans is frequently resistant to amphotericin B by Kontoyiannis, D. P., Lewis, R. E., May, G. S., Osherov, N., Rinaldi, M. G.

“…The high failure rate of amphotericin B‐based therapy in patients with Aspergillus nidulans infections may not be entirely a result of host factors as…”
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Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA by Osherov, N, Kontoyiannis, D P, Romans, A, May, G S

“…Triazoles selectively inhibit the cytochrome P-450-dependent C-14 lanosterol alpha-demethylase (P-450 14 alpha DM), a key enzyme in ergosterol biosynthesis in…”
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Structural Requirements for in Vivo Myosin I Function in Aspergillus nidulans by Osherov, Nir, Yamashita, Roxanne A., Chung, Yun-Shin, May, Gregory S.

“…We have investigated the minimal requirements of the tail region for myosin I function in vivo using the filamentous fungus Aspergillus nidulans. The CL3…”
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Aspergillus strain typing in the genomics era by Klaassen, C.H.W., Osherov, N.

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The Dictyostelium dual-specificity kinase splA is essential for spore differentiation by Nuckolls, G H, Osherov, N, Loomis, W F, Spudich, J A

“…We have studied the structure and function of the Dictyostelium kinase splA. A truncated form of the splA protein exhibited primarily tyrosine kinase activity…”
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The molecular mechanisms of conidial germination by Osherov, Nir, May, Gregory S

“…The asexual spore, or conidium, is critical in the life cycle of many fungi because it is the primary means for dispersion and serves as a ‘safe house’ for the…”
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Conidial Germination in Aspergillus nidulans Requires RAS Signaling and Protein Synthesis by Osherov, Nir, May, Gregory

“…The dormant spores of Aspergillus nidulans become competent for growth and nuclear division in a process called conidial germination. To analyze the molecular…”
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molecular mechanisms of conidial germination by Osherov, N, May, G.S

“…The asexual spore, or conidium, is critical in the life cycle of many fungi because it is the primary means for dispersion and serves as a 'safe house' for the…”
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Genomic Approach to Identification of Mutations Affecting Caspofungin Susceptibility in Saccharomyces cerevisiae by MARKOVICH, Sarit, YEKUTIEL, Aya, SHALIT, Itamar, SHADKCHAN, Yona, OSHEROV, Nir

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Anti-inflammatory effects of moxifloxacin on IL-8, IL-1β and TNF-α secretion and NFκB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus by Shalit, Itamar, Halperin, Drora, Haite, Debby, Levitov, Avital, Romano, Jacob, Osherov, Nir, Fabian, Ina

“…Objectives: We have previously shown that moxifloxacin conferred protective anti-inflammatory effects against Candida pneumonia in immunosuppressed mice…”
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Involvement of Secreted Aspergillus fumigatus Proteases in Disruption of the Actin Fiber Cytoskeleton and Loss of Focal Adhesion Sites in Infected A549 Lung Pneumocytes by Kogan, Tanya V., Jadoun, Jeries, Mittelman, Leonid, Hirschberg, Koret, Osherov, Nir

“…Aspergillus fumigatus is an opportunistic pathogenic fungus that predominantly infects the respiratory system. Penetration of the lung alveolar epithelium is a…”
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Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species by Kontoyiannis, Dimitrios P., Lewis, Russell E., Osherov, Nir, Albert, Nathaniel D., May, Gregory S.

“…Work in Saccharomyces cerevisiae and Cryptococcus neoformans suggests that caspofungin could interact with the calcineurin pathway. We examined the in vitro…”
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Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis by Shadkchan, Yona, Shemesh, Einav, Mirelman, David, Miron, Talia, Rabinkov, Aharon, Wilchek, Meir, Osherov, Nir

“…Objectives: The evaluation of allicin, the biologically active compound responsible for the antimicrobial activities of freshly crushed garlic cloves, in…”
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In Vitro Synergy of Caspofungin and Itraconazole against Aspergillus spp.: MIC versus Minimal Effective Concentration End Points by SHALIT, Itamar, SHADKCHAN, Yona, SAMRA, Zmira, OSHEROV, Nir

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Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant by Mircus, Gabriel, Hagag, Shelly, Levdansky, Emma, Sharon, Haim, Shadkchan, Yona, Shalit, Itamar, Osherov, Nir

“…Objectives Despite the need for novel drugs to combat fungal infections, antifungal drug discovery is currently limited by both the availability of suitable…”
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