Search Results - "Osenkowski, Pamela"

Processing, shedding, and endocytosis of membrane type 1-matrix metalloproteinase (MT1-MMP) by Osenkowski, Pamela, Toth, Marta, Fridman, Rafael

“…Matrix metalloproteinases (MMPs) are multidomain zinc‐dependent proteolytic enzymes that play pivotal roles in many normal and pathological processes. Some…”
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Evaluation of Educator & Student Use of & Attitudes toward Dissection & Dissection Alternatives by Osenkowski, Pamela, Green, Che, Tjaden, Anne, Cunniff, Peggy

“…Animal dissection has been routinely practiced in American biology classrooms for decades. With technological advancements, more states adopting student choice…”
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Differential Inhibition of Membrane Type 3 (MT3)-Matrix Metalloproteinase (MMP) and MT1-MMP by Tissue Inhibitor of Metalloproteinase (TIMP)-2 and TIMP-3 Regulates Pro-MMP-2 Activation by Zhao, Huiren, Bernardo, M. Margarida, Osenkowski, Pamela, Sohail, Anjum, Pei, Duanqing, Nagase, Hideaki, Kashiwagi, Masahide, Soloway, Paul D., DeClerck, Yves A., Fridman, Rafael

“…The membrane type (MT)-matrix metalloproteinases (MMPs) constitute a subgroup of membrane-anchored MMPs that are major mediators of pericellular proteolysis…”
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The Inactive 44-kDa Processed Form of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Enhances Proteolytic Activity via Regulation of Endocytosis of Active MT1-MMP by Cho, Jin-Ah, Osenkowski, Pamela, Zhao, Huiren, Kim, Seaho, Toth, Marta, Cole, Kristina, Aboukameel, Amro, Saliganan, Allen, Schuger, Lucia, Bonfil, R. Daniel, Fridman, Rafael

“…Membrane type 1 (MT1) matrix metalloproteinase (MMP-14) is a membrane-tethered MMP considered to be a major mediator of pericellular proteolysis. MT1-MMP is…”
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Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase by Toth, Marta, Osenkowski, Pamela, Hesek, Dusan, Brown, Stephen, Meroueh, Samy, Sakr, Wael, Mobashery, Shahriar, Fridman, Rafael

“…MT1-MMP (membrane type 1 matrix metalloproteinase) is a membrane-anchored MMP that can be shed to the extracellular milieu. In the present study we report the…”
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Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing by Osenkowski, Pamela, Meroueh, Samy O., Pavel, Dumitru, Mobashery, Shahriar, Fridman, Rafael

“…Membrane type 1 (MT1)-matrix metalloproteinase (MMP) is a major mediator of collagen degradation in the pericellular space in both physiological and…”
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Educators' Views on the Use of Dissection and Dissection Alternatives in American Biology Classrooms by Osenkowski, Pamela, Karaliunas, Ignas, Diorio, Merari

“…Animal dissection remains a common practice in American biology classrooms, despite the availability of dissection alternatives to study anatomy and…”
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Educators’ Views on the Use of Dissection and Dissection Alternatives in American Biology Classrooms by Osenkowski, Pamela, Karaliunas, Ignas, Diorio, Merari

“…Animal dissection remains a common practice in American biology classrooms, despite the availability of dissection alternatives to study anatomy and…”
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Educators' Views on Dissection Alternatives at the Onset of the COVID-19 Pandemic by Osenkowski, Pamela, Karaliunas, Ignas, Diorio, Merari

“…When the COVID-19 pandemic struck in 2020, many schools made the decision to cancel face-to-face classes and move instruction online. To better understand how…”
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Dog as the experimental model: Laboratory uses of dogs in the United States by Ward, Sherry L, Osenkowski, Pamela

“…Dogs are the experimental model in many types of biomedical research. Each year, hundreds of publications report the use of dogs in invasive biomedical…”
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Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment by Osenkowski, Pamela, Ye, Wenjuan, Wang, Rong, Wolfe, Michael S., Selkoe, Dennis J.

“…γ-Secretase is an unusual and ubiquitous aspartyl protease with an intramembrane catalytic site that cleaves many type-I integral membrane proteins, most…”
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Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations by Quintero-Monzon, Omar, Martin, Morgan M, Fernandez, Marty A, Cappello, Christina A, Krzysiak, Amanda J, Osenkowski, Pamela, Wolfe, Michael S

“…The amyloid β-peptide (Aβ), strongly implicated in the pathogenesis of Alzheimer’s disease (AD), is produced from the amyloid β-protein precursor (APP) through…”
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Animal Dissection vs. Non-Animal Teaching Methods: A Systematic Review of Pedagogical Value by Ormandy, Elisabeth, Schwab, Janella C, Suiter, Samantha, Green, Nicole, Oakley, Janice, Osenkowski, Pamela, Sumner, Christine

“…Animal dissection is practiced to varying degrees around the world and is particularly prevalent in North America throughout all levels of education. However,…”
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Complex Pattern of Membrane Type 1 Matrix Metalloproteinase Shedding by Toth, Marta, Hernandez-Barrantes, Sonia, Osenkowski, Pamela, Bernardo, M. Margarida, Gervasi, David C., Shimura, Yoichiro, Meroueh, Oussama, Kotra, Lakshmi P., Gálvez, Beatriz G., Arroyo, Alicia G., Mobashery, Shahriar, Fridman, Rafael

“…Membrane type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane MMP shown to play a critical role in normal development and in malignant…”
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Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution by Osenkowski, Pamela, Li, Hua, Ye, Wenjuan, Li, Dongyang, Aeschbach, Lorene, Fraering, Patrick C., Wolfe, Michael S., Selkoe, Dennis J., Li, Huilin

“…γ-Secretase, an integral membrane protein complex, catalyzes the intramembrane cleavage of the β-amyloid precursor protein (APP) during the neuronal production…”
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Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols by Wei, Han-Xun, Lu, Dai, Sun, Vivien, Zhang, Jing, Gu, Yongli, Osenkowski, Pamela, Ye, Wenjuan, Selkoe, Dennis J., Wolfe, Michael S., Augelli-Szafran, Corinne E.

“…[Display omitted] One therapeutic approach for Alzheimer’s disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the…”
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Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs by Lu, Dai, Wei, Han-Xun, Zhang, Jing, Gu, Yongli, Osenkowski, Pamela, Ye, Wenjuan, Selkoe, Dennis J., Wolfe, Michael S., Augelli-Szafran, Corinne E.

“…[Display omitted] γ-Secretase is one of two proteases directly involved in the production of the amyloid β-peptide (Aβ), which is pathogenic in Alzheimer’s…”
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SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells by McClung, Heather M., Thomas, Stacey L., Osenkowski, Pamela, Toth, Marta, Menon, Priya, Raz, Avraham, Fridman, Rafael, Rempel, Sandra A.

“…Secreted protein acidic and rich in cysteine (SPARC) is highly expressed in human gliomas and promotes glioma invasion. We have shown by cDNA array analysis…”
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Dissociation between Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer-Causing Presenilin Mutations by Quintero-Monzon, Omar, Martin, Morgan M., Fernandez, Marty A., Cappello, Christina A., Krzysiak, Amanda J., Osenkowski, Pamela, Wolfe, Michael S.

“…The amyloid β-peptide (Aβ), strongly implicated in the pathogenesis of Alzheimer’s disease (AD), is produced from the amyloid β-protein precursor (APP) through…”
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Dissociation between the Processivity and Total Activity of Delta g-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations by Quintero-Monzon, Omar, Martin, Morgan M, Fernandez, Marty A, Cappello, Christina A, Krzysiak, Amanda J, Osenkowski, Pamela, Wolfe, Michael S

“…The amyloid Delta *b-peptide (A Delta *b), strongly implicated in the pathogenesis of Alzheimer's disease (AD), is produced from the amyloid Delta *b-protein…”
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