Search Results - "Oscier, D. G."

13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia by Parker, H, Rose-Zerilli, M J J, Parker, A, Chaplin, T, Wade, R, Gardiner, A, Griffiths, M, Collins, A, Young, B D, Oscier, D G, Strefford, J C

“…Historically, genes targeted by recurrent chromosomal deletions have been identified within the smallest genomic region shared in all patients, the minimally…”
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Quantification of subclonal distributions of recurrent genomic aberrations in paired pre-treatment and relapse samples from patients with B-cell chronic lymphocytic leukemia by Knight, S J L, Yau, C, Clifford, R, Timbs, A T, Sadighi Akha, E, Dréau, H M, Burns, A, Ciria, C, Oscier, D G, Pettitt, A R, Dutton, S, Holmes, C C, Taylor, J, Cazier, J-B, Schuh, A

“…Genome-wide array approaches and sequencing analyses are powerful tools for identifying genetic aberrations in cancers, including leukemias and lymphomas…”
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Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial by Strefford, J C, Kadalayil, L, Forster, J, Rose-Zerilli, M J J, Parker, A, Lin, T T, Heppel, N, Norris, K, Gardiner, A, Davies, Z, Gonzalez de Castro, D, Else, M, Steele, A J, Parker, H, Stankovic, T, Pepper, C, Fegan, C, Baird, D, Collins, A, Catovsky, D, Oscier, D G

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A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL by Best, O G, Gardiner, A C, Majid, A, Walewska, R, Austen, B, Skowronska, A, Ibbotson, R, Stankovic, T, Dyer, M J S, Oscier, D G

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Guidelines on the management of Waldenström macroglobulinaemia by Johnson, S. A., Birchall, J., Luckie, C., Oscier, D. G., Owen, R. G.

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Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations by CORCORAN, M. M, MOULD, S. J, ORCHARD, J. A, IBBOTSON, R. E, CHAPMAN, R. M, BORIGHT, A. P, PLATT, C, TSUI, L.-C, SCHERER, S. W, OSCIER, D. G

“…The increased or inappropriate expression of genes with oncogenic properties through specific chromosome translocations is an important event in the…”
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Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B by BOYD, R. S, ADAM, P. J, HUDSON, L, SMITH, P, GRIFFITHS, M, WILLIS, T. G, KARRAN, E. L, OSCIER, D. G, CATOVSKY, D, TERRETT, J. A, DYER, M. J. S, PATEL, S, LOADER, J. A, BERRY, J, REDPATH, N. T, POYSER, H. R, FLETCHER, G. C, BURGESS, N. A, STAMPS, A. C

“…B-cell-specific plasma-membrane proteins are potential targets for either small molecule or antibody-based therapies. We have sought to annotate proteins…”
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The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia by DYER, M. J. S, OSCIER, D. G

“…B cell chronic lymphocytic leukemia (CLL) lacks a consistent genetic abnormality. However, immunoglobulin V(H) gene segment mutation analysis has provided…”
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Rapid amplification of immunoglobulin heavy chain switch ( ) translocation breakpoints using long-distance inverse PCR by SONOKI, T, WILLIS, T. G, OSCIER, D. G, KARRAN, E. L, SIEBERT, R, DYER, M. J. S

“…Molecular cloning of immunoglobulin heavy chain (IGH) translocation breakpoints identifies genes of biological importance in the development of normal and…”
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P2X7 polymorphism and chronic lymphocytic leukaemia: lack of correlation with incidence, survival and abnormalities of chromosome 12 by ZHANG, L. Y, IBBOTSON, R. E, ORCHARD, J. A, GARDINER, A. C, SEEAR, R. V, CHASE, A. J, OSCIER, D. G, CROSS, N. C. P

“…The P2X7 receptor, a plasma membrane ATP-gated ion channel that plays a role in lymphocyte apoptosis, has been suggested as an important contributory factor to…”
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Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial by Larrayoz, M, Rose-Zerilli, M J J, Kadalayil, L, Parker, H, Blakemore, S, Forster, J, Davis, Z, Steele, A J, Collins, A, Else, M, Catovsky, D, Oscier, D G, Strefford, J C

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Atypical lymphocyte morphology: an adverse prognostic factor for disease progression in stage A CLL independent of trisomy 12 by Oscier, D. G., Matutes, E., Copplestone, A., Pickering, R. M., Chapman, R., Gillingham, R., Catovsky, D., Hamblin, T. J.

“…We studied 270 patients with Binet stage A chronic lymphocytic leukaemia looking for adverse prognostic factors. In a multivariate analysis the following…”
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Fludarabine-related autoimmune haemolytic anaemia in patients with chronic lymphocytic leukaemia by Myint, H, Copplestone, J A, Orchard, J, Craig, V, Curtis, D, Prentice, A G, Hamon, M D, Oscier, D G, Hamblin, T J

“…We have treated 52 patients with chronic lymphocytic leukaemia (CLL) with fludarabine; 12 developed severe autoimmune haemolysis. Only three had a previous…”
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Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease by Rose-Zerilli, M J J, Gibson, J, Wang, J, Tapper, W, Davis, Z, Parker, H, Larrayoz, M, McCarthy, H, Walewska, R, Forster, J, Gardiner, A, Steele, A J, Chelala, C, Ennis, S, Collins, A, Oakes, C C, Oscier, D G, Strefford, J C

“…The biological features of IGHV-M chronic lymphocytic leukemia responsible for disease progression are still poorly understood. We undertook a longitudinal…”
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Lack of somatic hypermutation of IG VH genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene by KÜPPERS, R, SONOKI, T, SATTERWHITE, E, GESK, S, HARDER, L, OSCIER, D. G, TUCKER, P. W, DYER, M. J. S, SIEBERT, R

“…The t(2;14)(p13;q32.3) involving the BCL11A and IGH genes is a rare but recurrent chromosomal aberration in B-cell malignancies. Hitherto, juxtaposition of…”
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A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable disease by Best, O G, Gardiner, A C, Davis, Z A, Tracy, I, Ibbotson, R E, Majid, A, Dyer, M J S, Oscier, D G

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Cytogenetic and molecular abnormalities in chronic lymphocytic leukaemia by Oscier, D G

“…Genetic abnormalities are found in 50% of cases of chronic lymphocytic leukaemia (CLL) by cytogenetic analysis and in a higher percentage of patients using…”
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Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage by Britt-Compton, B, Lin, T T, Ahmed, G, Weston, V, Jones, R E, Fegan, C, Oscier, D G, Stankovic, T, Pepper, C, Baird, D M

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Telomere length in myelodysplastic syndromes by Boultwood, J., Fidler, C., Kusec, R., Rack, K., Elliott, P.J. W., Atoyebi, O., Chapman, R., Oscier, D. G., Wainscoat, J. S.

“…We have studied telomere length in the bone marrow cells or the granulocyte and lymphocyte cell fractions of 54 patients with myelodysplastic syndromes (MDS)…”
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Cytogenetic studies in splenic lymphoma with villous lymphocytes by Oscier, D G, Matutes, E, Gardiner, A, Glide, S, Mould, S, Brito-Babapulle, V, Ellis, J, Catovsky, D

“…We report the cytogenetic findings on 31 cases of splenic lymphoma with villous lymphocytes (SLVL). TPA stimulated cells from peripheral blood (28 cases),…”
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