Search Results - "Oscar, Millet"

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests by Masoodi, Mojgan, Gastaldelli, Amalia, Hyötyläinen, Tuulia, Arretxe, Enara, Alonso, Cristina, Gaggini, Melania, Brosnan, Julia, Anstee, Quentin M., Millet, Oscar, Ortiz, Pablo, Mato, Jose M., Dufour, Jean-Francois, Orešič, Matej

“…Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide and is often associated with aspects of metabolic syndrome. Despite…”
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Molecular Determinants of Chronic Liver Disease as Studied by NMR-Metabolomics by Embade, Nieves, Millet, Oscar

“…Chronic liver diseases are one of the major causess of mortality worldwide. It can manifest through many different forms including chronic virus infection,…”
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Effect of age and dietary habits on Red Blood Cell membrane fatty acids in a Southern Europe population (Basque Country) by Marrugat, Gerard, Cano, Ainara, Amézaga, Javier, Arranz, Sara, Embade, Nieves, Millet, Óscar, Ferreri, Carla, Tueros, Itziar

“…The levels of blood eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are very variable and, in general, low in most of the world population. In this…”
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NMR of glycoproteins: profiling, structure, conformation and interactions by Unione, Luca, Ardá, Ana, Jiménez-Barbero, Jesús, Millet, Oscar

“…•NMR is most suitable for the structural characterization of glycoproteins.•Protein overexpression in eukaryotic media can produce glycoproteins at high yield…”
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On the potentially spurious contributions of cosolutes in protein 15N relaxation dispersion measurements by Mateos, Borja, Millet, Oscar

“…•A rigorous quantification of the thermodynamics, kinetic and structural changes can be approached by relaxation dispersion methods on proteins.•Cosolutes…”
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SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum by Bruzzone, Chiara, Bizkarguenaga, Maider, Gil-Redondo, Rubén, Diercks, Tammo, Arana, Eunate, García de Vicuña, Aitor, Seco, Marisa, Bosch, Alexandre, Palazón, Asís, San Juan, Itxaso, Laín, Ana, Gil-Martínez, Jon, Bernardo-Seisdedos, Ganeko, Fernández-Ramos, David, Lopitz-Otsoa, Fernando, Embade, Nieves, Lu, Shelly, Mato, José M., Millet, Oscar

“…COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using…”
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Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor by Escobedo, Albert, Topal, Busra, Kunze, Micha B. A., Aranda, Juan, Chiesa, Giulio, Mungianu, Daniele, Bernardo-Seisdedos, Ganeko, Eftekharzadeh, Bahareh, Gairí, Margarida, Pierattelli, Roberta, Felli, Isabella C., Diercks, Tammo, Millet, Oscar, García, Jesús, Orozco, Modesto, Crehuet, Ramon, Lindorff-Larsen, Kresten, Salvatella, Xavier

“…Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in transcription factors. Tract length often correlates with…”
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Macromolecular Crowding Fails To Fold a Globular Protein in Cells by Schlesinger, Alexander P, Wang, Yaqiang, Tadeo, Xavier, Millet, Oscar, Pielak, Gary J

“…Proteins perform their functions in cells where macromolecular solutes reach concentrations of >300 g/L and occupy >30% of the volume. The volume excluded by…”
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Uneven metabolic and lipidomic profiles in recovered COVID‐19 patients as investigated by plasma NMR metabolomics by Bizkarguenaga, Maider, Bruzzone, Chiara, Gil‐Redondo, Rubén, SanJuan, Itxaso, Martin‐Ruiz, Itziar, Barriales, Diego, Palacios, Ainhoa, Pasco, Samuel T., González‐Valle, Beatriz, Laín, Ana, Herrera, Lara, Azkarate, Aida, Vesga, Miguel Angel, Eguizabal, Cristina, Anguita, Juan, Embade, Nieves, Mato, José M., Millet, Oscar

“…COVID‐19 is a systemic infectious disease that may affect many organs, accompanied by a measurable metabolic dysregulation. The disease is also associated with…”
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Seroprevalence of adeno-associated virus types 1, 2, 3, 4, 5, 6, 8, and 9 in a Basque cohort of healthy donors by Navarro-Oliveros, Miguel, Vidaurrazaga, Ander, Soares Guerra, Gabriel, Castellana, Donatello, Embade, Nieves, Millet, Oscar, Marigorta, Urko M., Abrescia, Nicola G. A.

“…Adeno-associated viruses (AAVs) are promising gene therapy vectors, but challenges arise when treating patients with preexisting neutralizing antibodies…”
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Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease by Barbier-Torres, Lucía, Murray, Ben, Yang, Jin Won, Wang, Jiaohong, Matsuda, Michitaka, Robinson, Aaron, Binek, Aleksandra, Fan, Wei, Fernández-Ramos, David, Lopitz-Otsoa, Fernando, Luque-Urbano, Maria, Millet, Oscar, Mavila, Nirmala, Peng, Hui, Ramani, Komal, Gottlieb, Roberta, Sun, Zhaoli, Liangpunsakul, Suthat, Seki, Ekihiro, Van Eyk, Jennifer E., Mato, Jose M., Lu, Shelly C.

“…MATα1 catalyzes the synthesis of S-adenosylmethionine, the principal biological methyl donor. Lower MATα1 activity and mitochondrial dysfunction occur in…”
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Preovulatory follicular fluid secretome added to in vitro maturation medium influences the metabolism of equine cumulus-oocyte complexes by Luis-Calero, Marcos, Ortiz-Rodríguez, José Manuel, Fernández-Hernández, Pablo, Muñoz-García, Carmen Cristina, Pericuesta, Eva, Gutiérrez-Adán, Alfonso, Marinaro, Federica, Embade, Nieves, Conde, Ricardo, Bizkarguenaga, Maider, Millet, Óscar, González-Fernández, Lauro, Macías-García, Beatriz

“…In vitro embryo production is a highly demanded reproductive technology in horses, which requires the recovery (in vivo or post-mortem) and in vitro maturation…”
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A glutamine-based single α-helix scaffold to target globular proteins by Escobedo, Albert, Piccirillo, Jonathan, Aranda, Juan, Diercks, Tammo, Mateos, Borja, Garcia-Cabau, Carla, Sánchez-Navarro, Macarena, Topal, Busra, Biesaga, Mateusz, Staby, Lasse, Kragelund, Birthe B., García, Jesús, Millet, Oscar, Orozco, Modesto, Coles, Murray, Crehuet, Ramon, Salvatella, Xavier

“…The binding of intrinsically disordered proteins to globular ones can require the folding of motifs into α-helices. These interactions offer opportunities for…”
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Structural basis for the aminoacid composition of proteins from halophilic archea by Tadeo, Xavier, López-Méndez, Blanca, Trigueros, Tamara, Laín, Ana, Castaño, David, Millet, Oscar

“…Proteins from halophilic organisms, which live in extreme saline conditions, have evolved to remain folded at very high ionic strengths. The surfaces of…”
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Intrinsic dynamics of an enzyme underlies catalysis by Millet, Oscar, Labeikovsky, Wladimir, Bosco, Daryl A, Eisenmesser, Elan Z, Korzhnev, Dmitry M, Wolf-Watz, Magnus, Skalicky, Jack J, Kern, Dorothee, Kay, Lewis E

“…A unique feature of chemical catalysis mediated by enzymes is that the catalytically reactive atoms are embedded within a folded protein. Although current…”
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Quantitative Analysis of the Human Semen Phosphorometabolome by 31P-NMR by Serrano, Rebeca, Martin-Hidalgo, David, Bilbao, Jon, Bernardo-Seisdedos, Ganeko, Millet, Oscar, Garcia-Marin, Luis J., Bragado, Maria Julia

“…Phosphorus-containing metabolites occupy a prominent position in cell pathways. The phosphorometabolomic approach in human sperm samples will deliver valuable…”
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Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19 by Bruzzone, Chiara, Conde, Ricardo, Embade, Nieves, Mato, José M, Millet, Oscar

“…COVID-19 currently represents one of the major health challenges worldwide. Albeit its infectious character, with onset affectation mainly at the respiratory…”
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A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants by Egia-Mendikute, Leire, Bosch, Alexandre, Prieto-Fernández, Endika, Vila-Vecilla, Laura, Zanetti, Samanta Romina, Lee, So Young, Jiménez-Lasheras, Borja, García Del Río, Ana, Antoñana-Vildosola, Asier, de Blas, Ander, Velasco-Beltrán, Paloma, Serrano-Maciá, Marina, Iruzubieta, Paula, Mehrpouyan, Majid, Goldberg, Edward M, Bornheimer, Scott J, Embade, Nieves, Martínez-Chantar, María L, López-Hoyos, Marcos, Mato, José M, Millet, Óscar, Palazón, Asís

“…Vaccines against SARS-CoV-2 have alleviated infection rates, hospitalization and deaths associated with COVID-19. In order to monitor humoral immunity, several…”
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Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites by Poveda, José A., Giudici, A. Marcela, Renart, M. Lourdes, Millet, Oscar, Morales, Andrés, González-Ros, José M., Oakes, Victoria, Furini, Simone, Domene, Carmen

“…The role of arginines R64 and R89 at non-annular lipid binding sites of KcsA, on the modulation of channel activity by anionic lipids has been investigated. In…”
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Bioengineered PBGD variant improves the therapeutic index of gene therapy vectors for acute intermittent porphyria by Serrano-Mendioroz, Irantzu, Sampedro, Ana, Serna, Naroa, de Salamanca, Rafael Enríquez, Sanz-Parra, Arantza, Corrales, Fernando, Berraondo, Pedro, Millet, Oscar, Fontanellas, Antonio

“…Abstract A first-in-human gene therapy trial using a recombinant adeno-associated viral (rAAV) vector for acute intermittent porphyria (AIP) reveals that…”
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