Search Results - "Osborne, William R."

Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity by Chen, Lihua, DeWispelaere, Allison, Dastvan, Frank, Osborne, William R A, Blechner, Christine, Windhorst, Sabine, Daum, Guenter

“…Smooth muscle alpha-actin (SMA) is a marker for the contractile, non-proliferative phenotype of adult smooth muscle cells (SMCs). Upon arterial injury,…”
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Effects of exendin-4, a glucagon like peptide-1 receptor agonist, on neutrophil count and inflammatory cytokines in a rat model of endotoxemia by Yanay, Ofer, Bailey, Adam L, Kernan, Kelly, Zimmerman, Jerry J, Osborne, William R

“…Sepsis remains a major cause of morbidity and mortality. A variety of strategies targeting modulation of the pro-inflammatory response associated with early…”
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The Early Messianic 'Afterlife' of the Tree Metaphor in Ezekiel 17:22-24 by William R. Osborne

“…This article discusses the royal associations of tree imagery in the ancient Near East before examining four early messianic interpretations of the tree…”
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Repeated lentivirus-mediated granulocyte colony-stimulating factor administration to treat canine cyclic neutropenia by Yanay, Ofer, Dale, David C, Osborne, William R A

“…Cyclic neutropenia occurs in humans and gray collie dogs, is characterized by recurrent neutropenia, and is treated by repeated injections of recombinant…”
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Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter by FITZGERALD, Sara M, GOYAL, Rakesh K, OSBORNE, William R. A, ROY, Jennifer D, WILSON, John W, FERRELL, R. E

“…Cytidine deaminase (CDA) hydrolytically deaminates and irreversibly deactivates the chemotherapeutic agent cytosine arabinoside (Ara-C), a deoxycytidine analog…”
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Serum amyloid A impairs the antiinflammatory properties of HDL by Han, Chang Yeop, Tang, Chongren, Guevara, Myriam E, Wei, Hao, Wietecha, Tomasz, Shao, Baohai, Subramanian, Savitha, Omer, Mohamed, Wang, Shari, O'Brien, Kevin D, Marcovina, Santica M, Wight, Thomas N, Vaisar, Tomas, de Beer, Maria C, de Beer, Frederick C, Osborne, William R, Elkon, Keith B, Chait, Alan

“…HDL from healthy humans and lean mice inhibits palmitate-induced adipocyte inflammation; however, the effect of the inflammatory state on the functional…”
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Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1 by Yanay, Ofer, Moralejo, Daniel, Kernan, Kelly, Brzezinski, Margaret, Fuller, Jessica M., Barton, Randall W., Lernmark, Ake, Osborne, William R.

“…Background Type 1 diabetes (T1D) in both humans and BioBreeding (BB) rats is an autoimmune disease that results in complete destruction of islets and insulin…”
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Serum amyloid A impairs the antiinflammatory properties of HDL by Han, Chang Yeop, Tang, Chongren, Guevara, Myriam E, Wei, Hao, Wietecha, Tomasz, Shao, Baohai, Subramanian, Savitha, Omer, Mohamed, Wang, Shari, O'Brien, Kevin D, Marcovina, Santica M, Wight, Thomas N, Vaisar, Tomas, de Beer, Maria C, de Beer, Frederick C, Osborne, William R, Elkon, Keith B, Chait, Alan

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Treatment of canine cyclic neutropenia by lentivirus-mediated G-CSF delivery by Yanay, Ofer, Barry, Simon C., Katen, Louis J., Brzezinski, Margaret, Flint, Lisa Y., Christensen, Jeffrey, Liggitt, Denny, Dale, David C., Osborne, William R.A.

“…Cyclic neutropenia is a rare disease that occurs both in humans and gray collie dogs and is characterized by recurrent severe neutropenia leading to bacterial…”
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Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin by Seppen, Jurgen, Barry, Simon C., Harder, Brandon, Osborne, William R.A.

“…A lentivirus pseudotyped with vesicular stomatitis virus G protein (VSV-G) encoding rat erythropoietin (EPO) complementary DNA was administered to rat skeletal…”
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Treatment of diabetic rats with encapsulated islets by Sweet, Ian R., Yanay, Ofer, Waldron, Lanaya, Gilbert, Merle, Fuller, Jessica M., Tupling, Terry, Lernmark, Ake, Osborne, William R. A.

“…Immunoprotection of islets using bioisolator systems permits introduction of allogeneic cells to diabetic patients without the need for immunosuppression…”
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Glucose-regulated insulin production from genetically engineered human non-beta cells by Tatake, Revati J., O'Neill, Margaret M., Kennedy, Charles A., Reale, Virginia D., Runyan, Jacob D., Monaco, Kelli-Ann D., Yu, Kyung, Osborne, William R., Barton, Randall W., Schneiderman, Richard D.

“…In this report we describe development and characterization of four human cell lines that are able to secrete insulin and C-peptide in response to higher…”
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G-CSF-lentivirus administration in rats provided sustained elevated neutrophil counts and subsequent EPO-lentivirus administration increased hematocrits by Brzezinski, Margaret, Yanay, Ofer, Waldron, Lanaya, Barry, Simon C., Osborne, William R. A.

“…Background Towards gene therapy treatment of patients with neutropenia, characterized by neutrophil counts < 500 cells/µl, we investigated the ability of…”
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An adult dog with cyclic neutropenia treated by lentivirus- mediated delivery of granulocyte colony-stimulating factor by Yanay, Ofer, Brzezinski, Margaret, Christensen, Jeffrey, Liggitt, Denny, Dale, David C, Osborne, William R A

“…Cyclic neutropenia occurs in humans and gray collie dogs, is characterized by recurrent neutropenia, and is treated by daily injections of recombinant…”
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Isolation and long-term culture of gallbladder epithelial cells from wild-type and CF mice by Kuver, Rahul, Savard, Christopher, Nguyen, Toan D, Osborne, William R. A, Lee, Sum P

“…Mice with targeted disruption of the cftr gene show pathophysiologic changes in the gallbladder, which correlate with hepatobiliary disease seen in cystic…”
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Long-term erythropoietin gene expression from transduced cells in bioisolator devices by Yanay, Ofer, Barry, Simon C, Flint, Lisa Y, Brzezinski, Margaret, Barton, Randall W, Osborne, William R A

“…Recombinant erythropoietin (EPO) is widely administered for long-term treatment of anemia associated with renal failure and other chronic diseases. The ability…”
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Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery by Barry, Simon, Brzezinski, Margaret, Yanay, Ofer, Seppen, Jurgen E., Osborne, William R. A.

“…Background Patients with severe chronic and cyclic neutropenia, characterized by neutrophil numbers <500 cells/µl, are treated daily with recombinant…”
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Modified blasticidin S resistance gene ( bsrm) as a selectable marker for construction of retroviral vectors by Freitas, Antonio C., Bento, Fernanda M., Ramesh, Nagarajan, Osborne, William R.A., Han, Sang W.

“…Retroviral vectors are commonly used in ex vivo gene therapy protocols. The structure of vectors basically consists of one gene of interest and a selectable…”
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Apical Gene Transfer into Quiescent Human and Canine Polarized Intestinal Epithelial Cells by Lentivirus Vectors by Seppen, J, Barry, S C, Klinkspoor, J H, Katen, L J, Lee, S P, Garcia, J V, Osborne, W R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Abstract 315: Inflamed HDL Loses Its Anti-inflammatory Properties on Adipocytes: Role of Interaction of Serum Amyloid A with the Extracellular Matrix by Han, Chang Yeop, Tang, Chongren, Omer, Mohamed, Wang, Shari, Vaisar, Tomas, Wight, Thomas N, Osborne, William R, Chait, Alan

“…Abstract only Obesity induces adipocyte hypertrophy and accumulation of macrophages in adipose tissue, which associates with insulin resistance and…”
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