Search Results - "Osborne, P. B."

Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow by Mendis, G. D. C., Berecki, G., Morrisroe, E., Pachernegg, S., Li, M., Varney, M., Osborne, P. B., Reid, C. A., Halgamuge, S., Petrou, S.

“…Determining the mechanism of action (MOA) of novel or naturally occurring compounds mostly relies on assays tailored for individual target proteins. Here we…”
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Regional Targeting of Bladder and Urethra Afferents in the Lumbosacral Spinal Cord of Male and Female Rats: A Multiscale Analysis by Fuller-Jackson, J P, Osborne, P B, Keast, J R

“…Sensorimotor circuits of the lumbosacral spinal cord are required for lower urinary tract (LUT) regulation as well as being engaged in pelvic pain states. To…”
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Localization of immunoreactivity for Deleted in Colorectal Cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents by Osborne, P.B., Halliday, G.M., Cooper, H.M., Keast, J.R.

“…DCC (deleted in colorectal cancer)—the receptor of the netrin-1 neuronal guidance factor—is expressed and is active in the central nervous system (CNS) during…”
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Postnatal Maturational Changes in Rat Pelvic Autonomic Ganglion Cells: A Mixture of Steroid-Dependent and -Independent Effects by Kanjhan, R, Osborne, P. B, Ouyang, M, Keast, J. R

“…  1 Prince of Wales Medical Research Institute, University of New South Wales, Sydney 2031; and   2 Department of Physiology and Pharmacology, University of…”
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Effect of naloxone-precipitated morphine withdrawal on c- fos expression in rat corticotropin-releasing hormone neurons in the paraventricular hypothalamus and extended amygdala by Hamlin, A.S., Buller, K.M., Day, T.A., Osborne, P.B.

“…Morphine withdrawal is characterized by physical symptoms and a negative affective state. The 41 amino acid polypeptide corticotropin-releasing hormone (CRH)…”
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Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro by Pan, Z Z, Williams, J T, Osborne, P B

“…1. Intracellular recordings were made from neurons of the nucleus raphe magnus (NRM) from rat (n = 128) and guinea-pig (n = 115). Two types of cells were found…”
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Dissection of peripheral and central endogenous opioid modulation of systemic interleukin-1β responses using c- fos expression in the rat brain by Buller, K.M., Hamlin, A.S., Osborne, P.B.

“…In opiate addicts or patients receiving morphine treatment, it has been reported that the immune system is often compromised. The mechanisms responsible for…”
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Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats by Hamlin, A, Buller, K.M, Day, T.A, Osborne, P.B

“…This study examined if brain pathways in morphine-dependent rats are activated by opioid withdrawal precipitated outside the central nervous system. Withdrawal…”
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Identification of a Sacral, Visceral Sensory Transcriptome in Embryonic and Adult Mice by Smith-Anttila, C J A, Mason, E A, Wells, C A, Aronow, B J, Osborne, P B, Keast, J R

“…Visceral sensory neurons encode distinct sensations from healthy organs and initiate pain states that are resistant to common analgesics. Transcriptome…”
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Opioid inhibition of rat periaqueductal grey neurones with identified projections to rostral ventromedial medulla in vitro by Osborne, P B, Vaughan, C W, Wilson, H I, Christie, M J

“…1. Rat caudal periaqueductal grey (PAG) output neurones containing rhodamine microspheres, retrogradely transported from an injection site in the rostral…”
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Characterization of acute homologous desensitization of μ‐opioid receptor‐induced currents in locus coeruleus neurones by Osborne, P.B., Williams, J.T.

“…1 Acute homologous desensitization of μ‐opioid receptor‐induced currents was pharmacologically characterized in locus coeruleus (LC) neurones by use of…”
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Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels by Kavanaugh, M P, Varnum, M D, Osborne, P B, Christie, M J, Busch, A E, Adelman, J P, North, R A

“…Extracellular tetraethylammonium (TEA) inhibits currents in Xenopus oocytes that have been injected with mRNAs encoding voltage-dependent potassium channels…”
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Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels by Hurst, R S, Busch, A E, Kavanaugh, M P, Osborne, P B, North, R A, Adelman, J P

“…alpha-Dendrotoxin (DTX) is a 60-amino acid peptide belonging to the family of mamba snake neurotoxins; it is a potent blocker of some but not all voltage-gated…”
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Where is the locus in opioid withdrawal? by Christie, MacDonald J., Williams, J.T., Osborne, P.B., Bellchambers, C.E.

“…Identification of neuroadaptations in specific brain regions that generate withdrawal is crucial for understanding and perhaps treating opioid dependence. It…”
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Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits by Christie, M J, North, R A, Osborne, P B, Douglass, J, Adelman, J P

“…Voltage-dependent potassium currents were measured in Xenopus oocytes previously injected with RNAs generated in vitro from each of three cloned cDNAs (RBK1,…”
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Forskolin enhancement of opioid currents in rat locus coeruleus neurons by Osborne, P B, Williams, J T

“…1. Opioids are known to hyperpolarize all neurons in the nucleus locus coeruleus (LC) and to inhibit adenylyl cyclase. Recent work has shown that activation of…”
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μ‐Opioid receptor desensitization: Is morphine different? by Connor, Mark, Osborne, Peregrine B, Christie, MacDonald J

“…Opioid tolerance and dependence are important phenomena. The contribution of acute μ‐opioid receptor regulatory mechanisms to the development of analgesic…”
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Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel by Douglass, J, Osborne, PB, Cai, YC, Wilkinson, M, Christie, MJ, Adelman, JP

“…Low stringency hybridization screening of a rat genomic DNA library with a previously described cDNA clone encoding a rat voltage-gated potassium channel has…”
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Galanin-like immunoreactivity in sympathetic and parasympathetic neurons of the toad Bufo marinus by Morris, J L, Gibbins, I L, Osborne, P B

“…Immunoreactivity (IR) to galanin (GAL) was detected in a wide range of peripheral autonomic neurons in the toad Bufo marinus. Forty percent of adrenergic nerve…”
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Opioid Agonists Have Different Efficacy Profiles for G Protein Activation, Rapid Desensitization, and Endocytosis of Mu-opioid Receptors by Borgland, Stephanie L., Connor, Mark, Osborne, Peregrine B., Furness, John B., Christie, MacDonald J.

“…The differential ability of various μ-opioid receptor (MOP) agonists to induce rapid receptor desensitization and endocytosis of MOP could arise simply from…”
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