Search Results - "Osborne, Douglas"

CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma by Ravindran Menon, Dinoop, Luo, Yuchun, Arcaroli, John J, Liu, Sucai, KrishnanKutty, Lekha Nair, Osborne, Douglas G, Li, Yang, Samson, Jenny Mae, Bagby, Stacey, Tan, Aik-Choon, Robinson, William A, Messersmith, Wells A, Fujita, Mayumi

“…Cancers are composed of heterogeneous subpopulations with various tumor-initiating capacities, yet key stem cell genes associated with enhanced…”
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Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion by Tengesdal, Isak W., Menon, Dinoop R., Osborne, Douglas G., Neff, Charles P., Powers, Nicholas E., Gamboni, Fabia, Mauro, Adolfo G., D’Alessandro, Angelo, Stefanoni, Davide, Henen, Morkos A., Mills, Taylor S., DeGraaf, Dennis M., Azam, Tania, Vogeli, Beat, Palmer, Brent E., Pietras, Eric M., DeGregori, James, Tan, Aik-Choon, Joosten, Leo A. B., Fujita, Mayumi, Dinarello, Charles A., Marchetti, Carlo

“…Interleukin-1β (IL-1β)–mediated inflammation suppresses antitumor immunity, leading to the generation of a tumor-permissive environment, tumor growth, and…”
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COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A by Phillips-Krawczak, Christine A, Singla, Amika, Starokadomskyy, Petro, Deng, Zhihui, Osborne, Douglas G, Li, Haiying, Dick, Christopher J, Gomez, Timothy S, Koenecke, Megan, Zhang, Jin-San, Dai, Haiming, Sifuentes-Dominguez, Luis F, Geng, Linda N, Kaufmann, Scott H, Hein, Marco Y, Wallis, Mathew, McGaughran, Julie, Gecz, Jozef, Sluis, Bart van de, Billadeau, Daniel D, Burstein, Ezra

“…COMMD1 deficiency results in defective copper homeostasis, but the mechanism for this has remained elusive. Here we report that COMMD1 is directly linked to…”
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Structural and mechanistic insights into regulation of the retromer coat by TBC1d5 by Jia, Da, Zhang, Jin-San, Li, Fang, Wang, Jing, Deng, Zhihui, White, Mark A., Osborne, Douglas G., Phillips-Krawczak, Christine, Gomez, Timothy S., Li, Haiying, Singla, Amika, Burstein, Ezra, Billadeau, Daniel D., Rosen, Michael K.

“…Retromer is a membrane coat complex that is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. The timing of this interaction and consequent…”
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Not all sanctuaries are created equal: variation in protected area selection by wintering mallards by Dittmer, Ethan M., Askren, Ryan J., Hagy, Heath M., Hitchcock, Jay, Osborne, Douglas C.

“…Public lands managed for wildlife frequently provide various forms of sanctuary to increase residency times and allow access to energetic and other habitat…”
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Immunity to Influenza is dependent on MHC II polymorphism: study with 2 HLA transgenic strains by Luckey, David, Weaver, Eric A., Osborne, Douglas G., Billadeau, Daniel D., Taneja, Veena

“…Major histocompatibility complex II (MHC II) molecules are involved in antigen presentation and the development of a functional adaptive immune response…”
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Trogocytosis results in sustained intracellular signaling in CD4(+) T cells by Osborne, Douglas G, Wetzel, Scott A

“…CD4(+) T cells capture membrane and membrane-bound molecules from APCs directly from the immunological synapse in a process termed trogocytosis. The function…”
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Distributional shifts of wintering midcontinent greater white‐fronted geese by Moore, Callie B., Osborne, Douglas C., Askren, Ryan J., Carlson, Lindsay G., Brasher, Michael G.

“…Despite a historically large degree of philopatry to the Gulf Coastal Plains wintering area in the United States and Mexico, the midcontinent population of…”
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Citizen science reveals waterfowl responses to extreme winter weather by Masto, Nicholas M., Robinson, Orin J., Brasher, Michael G., Keever, Allison C., Blake‐Bradshaw, Abigail G., Highway, Cory J., Feddersen, Jamie C., Hagy, Heath M., Osborne, Douglas C., Combs, Daniel L., Cohen, Bradley S.

“…Global climate change is increasing the frequency and severity of extreme climatic events (ECEs) which may be especially detrimental during late‐winter when…”
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Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation by Johnson, Jennifer L., Meneses-Salas, Elsa, Ramadass, Mahalakshmi, Monfregola, Jlenia, Rahman, Farhana, Carvalho Gontijo, Raquel, Kiosses, William B., Pestonjamasp, Kersi, Allen, Dale, Zhang, Jinzhong, Osborne, Douglas G., Zhu, Yanfang Peipei, Wineinger, Nathan, Askari, Kasra, Chen, Danni, Yu, Juan, Henderson, Scott C., Hedrick, Catherine C., Ursini, Matilde Valeria, Grinstein, Sergio, Billadeau, Daniel D., Catz, Sergio D.

“…Dysregulated secretion in neutrophil leukocytes associates with human inflammatory disease. The exocytosis response to triggering stimuli is sequential;…”
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TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL by Kremer, Kimberly N., Dinkel, Brittney A., Sterner, Rosalie M., Osborne, Douglas G., Jevremovic, Dragan, Hedin, Karen E.

“…As with many immunopathologically driven diseases, the malignant T cells of cutaneous T-cell lymphomas (CTCLs), such as Sézary syndrome, display aberrant…”
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Interleukin‐37 is highly expressed in regulatory T cells of melanoma patients and enhanced by melanoma cell secretome by Osborne, Douglas G., Domenico, Joanne, Luo, Yuchun, Reid, Anna L., Amato, Carol, Zhai, Zili, Gao, Dexiang, Ziman, Melanie, Dinarello, Charles A., Robinson, William A., Fujita, Mayumi

“…Immune suppression is one of the 10 hallmarks of cancer. Interleukin‐37 (IL‐37), a member of the IL‐1 family, inhibits both innate and adaptive immunity, and…”
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Spring migration strategies of Anas platyrhynchos (Mallard) necessitate individual time-energy trade-offs despite wintering origins or migratory destinations by Masto, Nicholas M, Blake-Bradshaw, Abigail G, Highway, Cory J, Keever, Allison C, Feddersen, Jamie C, Link, Paul T, Hagy, Heath M, Osborne, Douglas C, Cohen, Bradley S

“…Abstract Spring migration is hypothesized to be time-constrained because of competition for optimal nesting and brood-rearing sites. Therefore, individuals are…”
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Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation by Walpole, Glenn F.W., Plumb, Jonathan D., Chung, Daniel, Tang, Brandon, Boulay, Benoit, Osborne, Douglas G., Piotrowski, Joshua T., Catz, Sergio D., Billadeau, Daniel D., Grinstein, Sergio, Jaumouillé, Valentin

“…Burkholderia cenocepacia is an opportunistic bacterial pathogen that causes severe pulmonary infections in cystic fibrosis and chronic granulomatous disease…”
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SNX17 affects T cell activation by regulating TCR and integrin recycling by Osborne, Douglas G, Piotrowski, Joshua T, Dick, Christopher J, Zhang, Jin-San, Billadeau, Daniel D

“…A key component in T cell activation is the endosomal recycling of receptors to the cell surface, thereby allowing continual integration of signaling and Ag…”
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Caught out in the cold: Anas platyrhynchos (Mallard) survival decreased during an extreme climatic event by Blake-Bradshaw, Abigail G, Masto, Nicholas M, Highway, Cory J, Keever, Allison C, Link, Paul T, Feddersen, Jamie C, Hagy, Heath M, Osborne, Douglas C, Cohen, Bradley S

“…Abstract Extreme climatic events (ECEs) can have profound impacts on individual fitness, affecting survival directly or indirectly. Late winter ECEs may be…”
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Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis by Knitz, Michael W, Bickett, Thomas E, Darragh, Laurel B, Oweida, Ayman J, Bhatia, Shilpa, Van Court, Benjamin, Bhuvane, Shiv, Piper, Miles, Gadwa, Jacob, Mueller, Adam C, Nguyen, Diemmy, Nangia, Varuna, Osborne, Douglas G, Bai, Xiyuan, Ferrara, Sarah E, Boss, Mary-Keara, Goodspeed, Andrew, Burchill, Matthew A, Tamburini, Beth A Jirón, Chan, Edward D, Pickering, Curtis R, Clambey, Eric T, Karam, Sana D

“…BackgroundNumerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical…”
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Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells by Deng, Zhi-Hui, Gomez, Timothy S, Osborne, Douglas G, Phillips-Krawczak, Christine A, Zhang, Jin-San, Billadeau, Daniel D

“…The pentameric WASH complex is best known for its role in regulating receptor trafficking from retromer-rich endosomal subdomains. FAM21 functions to stabilize…”
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Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming by Graham, Daniel B, Osborne, Douglas G, Piotrowski, Joshua T, Gomez, Timothy S, Gmyrek, Grzegorz B, Akilesh, Holly M, Dani, Adish, Billadeau, Daniel D, Swat, Wojciech

“…Immature dendritic cells (DCs) maintain a highly dynamic pool of recycling MHCII that promotes sampling of environmental antigens for presentation to T helper…”
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Climate change beliefs among waterfowl hunters in Arkansas by Wallen, Kenneth E., Spears, Jake G., Linder, Taylor J., Osborne, Douglas C.

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