Search Results - "Osborne, David W."

Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures by Osborne, David W., Musakhanian, Jasmine

“…A heightened interest in (trans)dermal delivery is in part driven by the need to improve the existing skin therapies and also the demand for alternative routes…”
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Skin Penetration and Permeation Properties of Transcutol® in Complex Formulations by Musakhanian, Jasmine, Osborne, David W., Rodier, Jean-David

“…Percutaneous delivery is explored as alternative pathway for addressing the drawbacks associated with the oral administration of otherwise efficacious drugs…”
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Trial of Roflumilast Cream for Chronic Plaque Psoriasis by Lebwohl, Mark G, Papp, Kim A, Stein Gold, Linda, Gooderham, Melinda J, Kircik, Leon H, Draelos, Zoe D, Kempers, Steven E, Zirwas, Mathew, Smith, Kathleen, Osborne, David W, Trotman, Marie-Louise, Navale, Lynn, Merritt, Charlotte, Berk, David R, Welgus, Howard

“…A cream formulation of the phosphodiesterase type 4 inhibitor roflumilast, in two concentrations, led to higher percentages of patients with clearance or…”
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Pharmacokinetics of Roflumilast Cream in Chronic Plaque Psoriasis: Data from Phase I to Phase III Studies by Thurston, Archie W., Osborne, David W., Snyder, Scott, Higham, Robert C., Burnett, Patrick, Berk, David R.

“…Background Most patients with chronic plaque psoriasis receive topical treatment; however, available options lack a balance of efficacy with long-term safety…”
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Diethylene glycol monoethyl ether: an emerging solvent in topical dermatology products by Osborne, David W

“…Summary Background  The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a…”
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Cremophor-free intravenous microemulsions for paclitaxel I. Formulation, cytotoxicity and hemolysis by NORNOO, Adwoa O, OSBORNE, David W, CHOW, Diana S.-L

“…Two cremophor-free microemulsions, lecithin:butanol:myvacet oil:water (LBMW) and capmul:myvacet oil:water (CMW) for paclitaxel (PAC) were developed for…”
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Cremophor-free intravenous microemulsions for paclitaxelI: Formulation, cytotoxicity and hemolysis by Nornoo, Adwoa O., Osborne, David W., Chow, Diana S.-L.

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Gel Formulation Containing Mixed Surfactant and Lipids Associating with Carboplatin by Woll, Kellie A., Schuchardt, Elie J., Willis, Claire R., Ortengren, Christopher D., Hendricks, Noah, Johnson, Mitch, Gaidamauskas, Ernestas, Baruah, Bharat, Sostarecz, Audra G., Worley, Deanna R., Osborne, David W., Crans, Debbie C.

“…The interaction of amphiphilic molecules such as lipids and surfactants with the hydrophilic drug carboplatin was investigated to identify suitable…”
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Assessment of the Vehicle for Roflumilast Cream Compared to a Ceramide-Containing Moisturizing Cream in Mild Eczema by Draelos, Zoe Diana, Higham, Robert C, Osborne, David W, Seal, Melissa S, Burnett, Patrick, Berk, David R

“…Inflammatory dermatologic conditions suitable for topical treatments benefit from a hydrating vehicle that improves the skin barrier without irritation. This…”
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640 - Investigator- and patient-rated local tolerability in phase 3 trials of topical roflumilast in patients with psoriasis, seborrheic dermatitis, and atopic dermatitis by Bunick, Christopher G, Bhatia, Neal, Del Rosso, James, Draelos, Zoe D, Eichenfield, Lawrence F, Kircik, Leon H, Lebwohl, Mark G, Gooderham, Melinda, Green, Lawrence J, Hebert, Adelaide A, Vender, Ronald B, Zirwas, Matthew, Simpson, Eric L, Gold, Linda Stein, Seal, Melissa, Snyder, Scott, Osborne, David W, Burnett, Patrick, Higham, Robert C, Chu, David H, Berk, David R

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504 - Investigator- and patient-rated local tolerability in phase 3 trials of topical roflumilast in patients with psoriasis, seborrheic dermatitis, and atopic dermatitis by Bunick, Christopher G, Bhatia, Neal, Del Rosso, James, Draelos, Zoe D, Eichenfield, Lawrence F, Kircik, Leon H, Lebwohl, Mark G, Gooderham, Melinda, Green, Lawrence J, Hebert, Adelaide A, Vender, Ronald B, Zirwas, Matthew, Simpson, Eric L, Gold, Linda Stein, Seal, Melissa, Snyder, Scott, Osborne, David W, Burnett, Patrick, Higham, Robert C, Chu, David H, Berk, David R

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15309 ARQ-151, roflumilast cream, improved psoriasis in phase 2a study by Papp, Kim A., Gooderham, Melinda, Droege, Michael, Merritt, Charlotte, Osborne, David W., Berk, David R., Thurston, Archie W., Smith, Valerie H., Welgus, Howard

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Chest pain by Osborne, David W., Brown, David F.M., Nadel, Eric S.

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Continuous release, solid depot, subcutaneous leuprolide acetate formulations to achieve and maintain castrate level serum testosterone levels below 20ng/dL in 4 open label, fixed dose studies by Shore, Neal D., McLane, John A., Osborne, David W., Yang, Alex, Crawford, E. David

“…Abstract only…”
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Diethylene glycol monoethyl ether: an emerging solvent in topical dermatology products: DEGEE: an emerging solvent by Osborne, David W

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Randomized head-to-head prospective study of pharmacokinetic and pharmacodynamic properties of leuprolide acetate formulations: 7.5 mg single depot subcutaneous vs 7.5 mg intramuscular microsphere by Saltzstein, Daniel R., Moul, Judd W., de la Motte, Stephan, McLane, John A., Osborne, David W., Yang, Alex, Concepcion, Raoul S.

“…Abstract only…”
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Cremophor-free intravenous microemulsions for paclitaxel by Nornoo, Adwoa O., Osborne, David W., Chow, Diana S.-L.

“…Two cremophor-free microemulsions, lecithin:butanol:myvacet oil:water (LBMW) and capmul:myvacet oil:water (CMW) for paclitaxel (PAC) were developed for…”
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Symposium on Zwitterionic Surfactants: Preface by Osborne, David W, Ward, Anthony J. I

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Phase studies of zwitterionic surfactants: alkyl sulfobetaines by Faulkner, Patrick G, Ward, Anthony J. I, Osborne, David W

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Viscosities of solutions of lithium chloride in water-dimethyl sulfoxide mixtures at 25, 35, and 45.degree.C by Osborne, David W, O'Brien, James F

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