Search Results - "Osborne, Brenna"

The role of mitochondrial sirtuins in health and disease by Osborne, Brenna, Bentley, Nicholas L., Montgomery, Magdalene K., Turner, Nigel

“…Mitochondria play a critical role in energy production, cell signalling and cell survival. Defects in mitochondrial function contribute to the ageing process…”
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Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging by Das, Abhirup, Huang, George X., Bonkowski, Michael S., Longchamp, Alban, Li, Catherine, Schultz, Michael B., Kim, Lynn-Jee, Osborne, Brenna, Joshi, Sanket, Lu, Yuancheng, Treviño-Villarreal, Jose Humberto, Kang, Myung-Jin, Hung, Tzong-tyng, Lee, Brendan, Williams, Eric O., Igarashi, Masaki, Mitchell, James R., Wu, Lindsay E., Turner, Nigel, Arany, Zolt, Guarente, Leonard, Sinclair, David A.

“…A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in…”
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ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets by Du, Ximing, Zhou, Linkang, Aw, Yvette Celine, Mak, Hoi Yin, Xu, Yanqing, Rae, James, Wang, Wenmin, Zadoorian, Armella, Hancock, Sarah E, Osborne, Brenna, Chen, Xiang, Wu, Jia-Wei, Turner, Nigel, Parton, Robert G, Li, Peng, Yang, Hongyuan

“…Lipid droplets (LDs) are evolutionarily conserved organelles that play important roles in cellular metabolism. Each LD is enclosed by a monolayer of…”
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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism by Turner, Nigel, Lim, Xin Ying, Toop, Hamish D., Osborne, Brenna, Brandon, Amanda E., Taylor, Elysha N., Fiveash, Corrine E., Govindaraju, Hemna, Teo, Jonathan D., McEwen, Holly P., Couttas, Timothy A., Butler, Stephen M., Das, Abhirup, Kowalski, Greg M., Bruce, Clinton R., Hoehn, Kyle L., Fath, Thomas, Schmitz-Peiffer, Carsten, Cooney, Gregory J., Montgomery, Magdalene K., Morris, Jonathan C., Don, Anthony S.

“…Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models…”
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Repurposing Drugs to Target the Diabetes Epidemic by Turner, Nigel, Zeng, Xiao-Yi, Osborne, Brenna, Rogers, Suzanne, Ye, Ji-Ming

“…Despite major investment by pharmaceutical companies in conventional drug discovery pipelines, development of new drugs has failed to keep up with the…”
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Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer by Keijzers, Guido, Bakula, Daniela, Petr, Michael Angelo, Madsen, Nils Gedsig Kirkelund, Teklu, Amanuel, Mkrtchyan, Garik, Osborne, Brenna, Scheibye-Knudsen, Morten

“…Human exonuclease 1 (EXO1), a 5'→3' exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post…”
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Nuclear morphology is a deep learning biomarker of cellular senescence by Heckenbach, Indra, Mkrtchyan, Garik V, Ezra, Michael Ben, Bakula, Daniela, Madsen, Jakob Sture, Nielsen, Malte Hasle, Oró, Denise, Osborne, Brenna, Covarrubias, Anthony J, Idda, M Laura, Gorospe, Myriam, Mortensen, Laust, Verdin, Eric, Westendorp, Rudi, Scheibye-Knudsen, Morten

“…Cellular senescence is an important factor in aging and many age-related diseases, but understanding its role in health is challenging due to the lack of…”
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Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle[S] by Montgomery, Magdalene K., Osborne, Brenna, Brown, Simon H.J., Small, Lewin, Mitchell, Todd W., Cooney, Gregory J., Turner, Nigel

“…Dietary intake of long-chain fatty acids (LCFAs) plays a causative role in insulin resistance and risk of diabetes. Whereas LCFAs promote lipid accumulation…”
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Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84 by Montgomery, Magdalene K., Osborne, Brenna, Brandon, Amanda E., O'Reilly, Liam, Fiveash, Corrine E., Brown, Simon H. J., Wilkins, Brendan P., Samsudeen, Azrah, Yu, Josephine, Devanapalli, Beena, Hertzog, Ashley, Tolun, Adviye A., Kavanagh, Tomas, Cooper, Antony A., Mitchell, Todd W., Biden, Trevor J., Smith, Nicola J., Cooney, Gregory J., Turner, Nigel

“…Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium‐chain fatty acid…”
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Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging by Das, Abhirup, Huang, George X., Bonkowski, Michael S., Longchamp, Alban, Li, Catherine, Schultz, Michael B., Kim, Lynn-Jee, Osborne, Brenna, Joshi, Sanket, Lu, Yuancheng, Treviño-Villarreal, Jose Humberto, Kang, Myung-Jin, Hung, Tzong-tyng, Lee, Brendan, Williams, Eric O., Igarashi, Masaki, Mitchell, James R., Wu, Lindsay E., Turner, Nigel, Arany, Zolt, Guarente, Leonard, Sinclair, David A.

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dipeptidyl peptidase IV family in cancer and cell biology by Yu, Denise M.T, Yao, Tsun-Wen, Chowdhury, Sumaiya, Nadvi, Naveed A, Osborne, Brenna, Church, W. Bret, McCaughan, Geoffrey W, Gorrell, Mark D

“…Of the 600+ known proteases identified to date in mammals, a significant percentage is involved or implicated in pathogenic and cancer processes. The…”
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A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2 by Xi, Cecy R, Di Fazio, Arianna, Nadvi, Naveed Ahmed, Patel, Karishma, Xiang, Michelle Sui Wen, Zhang, Hui Emma, Deshpande, Chandrika, Low, Jason K K, Wang, Xiaonan Trixie, Chen, Yiqian, McMillan, Christopher L D, Isaacs, Ariel, Osborne, Brenna, Vieira de Ribeiro, Ana Júlia, McCaughan, Geoffrey W, Mackay, Joel P, Church, W Bret, Gorrell, Mark D

“…Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4…”
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Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice by Bentley, Nicholas L., Fiveash, Corrine E., Osborne, Brenna, Quek, Lake-Ee, Ogura, Masahito, Inagaki, Nobuya, Cooney, Gregory J., Polly, Patsie, Montgomery, Magdalene K., Turner, Nigel

“…Sirtuins are a family of evolutionary conserved enzymes that dynamically regulate cellular physiology. Mammals have 7 sirtuins, which are located in different…”
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Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs by Keane, Fiona M., Yao, Tsun-Wen, Seelk, Stefanie, Gall, Margaret G., Chowdhury, Sumaiya, Poplawski, Sarah E., Lai, Jack H., Li, Youhua, Wu, Wengen, Farrell, Penny, Vieira de Ribeiro, Ana Julia, Osborne, Brenna, Yu, Denise M.T., Seth, Devanshi, Rahman, Khairunnessa, Haber, Paul, Topaloglu, A. Kemal, Wang, Chuanmin, Thomson, Sally, Hennessy, Annemarie, Prins, John, Twigg, Stephen M., McLennan, Susan V., McCaughan, Geoffrey W., Bachovchin, William W., Gorrell, Mark D.

“…The protease fibroblast activation protein (FAP) is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. A specific, reliable…”
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Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism? by Osborne, Brenna, Cooney, Gregory J., Turner, Nigel

“…In recent years, reversible lysine acylation of proteins has emerged as a major post-translational modification across the cell, and importantly has been shown…”
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Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice by Osborne, Brenna, Reznick, Jane, Wright, Lauren E., Sinclair, David A., Cooney, Gregory J., Turner, Nigel

“…The mitochondrial enzyme SIRT3 is an NAD+-dependent deacetylase important in cell metabolism, and a decline in its protein expression or activity has been…”
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Small Molecule Inhibitor of Protein Kinase C DeltaI (PKCδI) Decreases Inflammatory Pathways and Gene Expression and Improves Metabolic Function in Diet-Induced Obese Mouse Model by Osborne, Brenna, Patel, Rekha S., Krause-Hauch, Meredith, Lui, Ashley, Vidyarthi, Gitanjali, Patel, Niketa A.

“…Obesity promotes metabolic diseases such as type 2 diabetes and cardiovascular disease. PKCδI is a serine/threonine kinase which regulates cell growth,…”
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7877 Adipose Depot Differences In Regenerative Properties Of Exosomes Derived From Human Adipose Stem Cells by Krause-Hauch, Meredith A, Patel, Rekha, Osborne, Brenna, Albear, Paul, Patel, Niketa A

“…Abstract Disclosure: M.A. Krause-Hauch: None. R. Patel: None. B. Osborne: None. P. Albear: None. N.A. Patel: None. Many patients struggle with chronic…”
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Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species by Montgomery, Magdalene K., Brown, Simon H.J., Lim, Xin Y., Fiveash, Corrine E., Osborne, Brenna, Bentley, Nicholas L., Braude, Jeremy P., Mitchell, Todd W., Coster, Adelle C.F., Don, Anthony S., Cooney, Gregory J., Schmitz-Peiffer, Carsten, Turner, Nigel

“…In a recent study, we showed that in response to high fat feeding C57BL/6, 129X1, DBA/2 and FVB/N mice all developed glucose intolerance, while BALB/c mice…”
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SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance by Osborne, Brenna, Wright, Lauren E, Brandon, Amanda E, Stuart, Ella, Small, Lewin, Hoeks, Joris, Schrauwen, Patrick, Sinclair, David A, Montgomery, Magdalene K, Cooney, Gregory J, Turner, Nigel

“…Reduced expression of the NAD+-dependent deacetylase, SIRT3, has been associated with insulin resistance and metabolic dysfunction in humans and rodents. In…”
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