Prevention of carbon tetrachloride-induced hepatotoxicity in the rat by H. rosasinensis anthocyanin extract administered in ethanol

The ability of anthocyanin obtained from the petals of H. rosasinensis to prevent carbon tetrachloride-induced acute liver damage in the rat was examined. Treatment of separate groups of rats with 2.5 ml of 1, 5 and 10% anthocyanin extract in 5% aqueous ethanol/kg body weight, 5 days/week for 4 week...

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Bibliographic Details
Published in:	Toxicology (Amsterdam) Vol. 131; no. 2; pp. 93 - 98
Main Authors:	Obi, Frederick Otunuya, Usenu, Ighofimoni Afonughe, Osayande, Julie Osaretin
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 16-11-1998 Amsterdam Elsevier Science
Subjects:	Alanine Transaminase - blood Animals Anthocyanin Anthocyanins - administration & dosage Anthocyanins - pharmacology Aspartate Aminotransferases - blood Biological and medical sciences Carbon tetrachloride Carbon Tetrachloride - toxicity Chemical and industrial products toxicology. Toxic occupational diseases Ethanol - administration & dosage Hepatotoxicity Liver Liver - drug effects Medical sciences Plant Extracts - pharmacology Rats Toxicology Various organic compounds Anthocyanin Hepatotoxicity Carbon tetrachloride Liver Malvaceae Rat Hepatoprotector Toxicity Rodentia Hepatic disease Flavonoid Hibiscus Prevention Vertebrata Mammalia Dicotyledones Animal Angiospermae Plant origin Spermatophyta
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Summary:	The ability of anthocyanin obtained from the petals of H. rosasinensis to prevent carbon tetrachloride-induced acute liver damage in the rat was examined. Treatment of separate groups of rats with 2.5 ml of 1, 5 and 10% anthocyanin extract in 5% aqueous ethanol/kg body weight, 5 days/week for 4 weeks before 0.5 ml/kg carbon tetrachloride (CCL 4) resulted in significantly ( P<0.05) less hepatotoxicity than with CCL 4 alone, as measured by serum aspartate and alanine aminotransferase activities 18 h after CCL 4. These data suggest that H. rosasinensis anthocyanin may be protective against carbon tetrachloride-induced liver injury.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0300-483X 1879-3185
DOI:	10.1016/S0300-483X(98)00119-X