Search Results - "Osawa, Keiko"

HIV-1 Virus-Like Particles Bearing Pure Env Trimers Expose Neutralizing Epitopes but Occlude Nonneutralizing Epitopes by TONG, Tommy, CROOKS, Ema T, OSAWA, Keiko, BINLEY, James M

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Enzyme Digests Eliminate Nonfunctional Env from HIV-1 Particle Surfaces, Leaving Native Env Trimers Intact and Viral Infectivity Unaffected by CROOKS, Ema T, TONG, Tommy, OSAWA, Keiko, BINLEY, James M

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Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals by TOMARAS, Georgia D, BINLEY, James M, DECKER, Julie, WIBMER, Constantinos Kurt, FENG GAO, ALAM, S. Munir, EASTERBROOK, Philippa, KARIM, Salim Abdool, KAMANGA, Gift, CRUMP, John A, COHEN, Myron, SHAW, George M, GRAY, Elin S, MASCOLA, John R, HAYNES, Barton F, MONTEFIORI, David C, MORRIS, Lynn, CROOKS, Emma T, OSAWA, Keiko, MOORE, Penny L, TUMBA, Nancy, TONG, Tommy, XIAOYING SHEN, YATES, Nicole L

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Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization by Binley, James M, Ban, Yih-En Andrew, Crooks, Emma T, Eggink, Dirk, Osawa, Keiko, Schief, William R, Sanders, Rogier W

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Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation by Crooks, Ema T, Grimley, Samantha L, Cully, Michelle, Osawa, Keiko, Dekkers, Gillian, Saunders, Kevin, Rämisch, Sebastian, Menis, Sergey, Schief, William R, Doria-Rose, Nicole, Haynes, Barton, Murrell, Ben, Cale, Evan Mitchel, Pegu, Amarendra, Mascola, John R, Vidarsson, Gestur, Binley, James M

“…The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb)…”
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Population genetic structure of the insular Ryukyu flying fox Pteropus dasymallus by Chen, Shiang‐Fan, Juan, Chung‐Hao, Rossiter, Stephen J., Kinjo, Teruo, Fukui, Dai, Kawai, Kuniko, Tsang, Susan M., Veluz, Maria Josefa, Sakurai, Hiroko, Lin, Hua‐Ching, Jang‐Liaw, Nian‐Hong, Osawa, Keiko, Ko, Wen‐Ya, Izawa, Masako

“…Small isolated populations are vulnerable to both stochastic events and the negative consequences of genetic drift. For threatened species, the genetic…”
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Topological Analysis of HIV-1 Glycoproteins Expressed In Situ on Virus Surfaces Reveals Tighter Packing but Greater Conformational Flexibility than for Soluble gp120 by Tong, Tommy, Osawa, Keiko, Robinson, James E, Crooks, Ema T, Binley, James M

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Impact of Glycan Depletion, Glycan Debranching and Increased Glycan Charge on HIV-1 Neutralization Sensitivity and Immunogenicity by D'Addabbo, Alessio, Tong, Tommy, Crooks, Emma T, Osawa, Keiko, Xu, Jiamin, Thomas, Alyssa, Allen, Joel D, Crispin, Max, Binley, James M

“…Broadly neutralizing antibodies (bNAbs) isolated from HIV-1 infected donors are vaccine paradigms. These bNAbs recognize envelope glycoprotein trimers that…”
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Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop by Cale, Evan M., Gorman, Jason, Radakovich, Nathan A., Crooks, Ema T., Osawa, Keiko, Tong, Tommy, Li, Jiaqi, Nagarajan, Raju, Ozorowski, Gabriel, Ambrozak, David R., Asokan, Mangai, Bailer, Robert T., Bennici, Anthony K., Chen, Xuejun, Doria-Rose, Nicole A., Druz, Aliaksandr, Feng, Yu, Joyce, M. Gordon, Louder, Mark K., O’Dell, Sijy, Oliver, Courtney, Pancera, Marie, Connors, Mark, Hope, Thomas J., Kepler, Thomas B., Wyatt, Richard T., Ward, Andrew B., Georgiev, Ivelin S., Kwong, Peter D., Mascola, John R., Binley, James M.

“…Most HIV-1-specific neutralizing antibodies isolated to date exhibit unusual characteristics that complicate their elicitation. Neutralizing antibodies that…”
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Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens by Emma T. Crooks, Francisco Almanza, Alessio D’Addabbo, Erika Duggan, Jinsong Zhang, Kshitij Wagh, Huihui Mou, Joel D. Allen, Alyssa Thomas, Keiko Osawa, Bette T. Korber, Yaroslav Tsybovsky, Evan Cale, John Nolan, Max Crispin, Laurent K. Verkoczy, James M. Binley

“…HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse,…”
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Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site by Crooks, Ema T, Tong, Tommy, Chakrabarti, Bimal, Narayan, Kristin, Georgiev, Ivelin S, Menis, Sergey, Huang, Xiaoxing, Kulp, Daniel, Osawa, Keiko, Muranaka, Janelle, Stewart-Jones, Guillaume, Destefano, Joanne, O'Dell, Sijy, LaBranche, Celia, Robinson, James E, Montefiori, David C, McKee, Krisha, Du, Sean X, Doria-Rose, Nicole, Kwong, Peter D, Mascola, John R, Zhu, Ping, Schief, William R, Wyatt, Richard T, Whalen, Robert G, Binley, James M

“…Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed…”
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Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction by Crooks, Ema T, Osawa, Keiko, Tong, Tommy, Grimley, Samantha L, Dai, Yang D, Whalen, Robert G, Kulp, Daniel W, Menis, Sergey, Schief, William R, Binley, James M

“…Abstract Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5):…”
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Multi-parameter exploration of HIV-1 virus-like particles as neutralizing antibody immunogens in guinea pigs, rabbits and macaques by Tong, Tommy, Crooks, Ema T, Osawa, Keiko, Robinson, James E, Barnes, Mary, Apetrei, Cristian, Binley, James M

“…Abstract Virus-like particles (VLPs) offer a platform to test the hypothesis that, since antibody binding to native envelope glycoprotein (Env) trimers results…”
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Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens by Crooks, Emma T, Almanza, Francisco, D'Addabbo, Alessio, Duggan, Erika, Zhang, Jinsong, Wagh, Kshitij, Mou, Huihui, Allen, Joel D, Thomas, Alyssa, Osawa, Keiko, Korber, Bette T, Tsybovsky, Yaroslav, Cale, Evan, Nolan, John, Crispin, Max, Verkoczy, Laurent K, Binley, James M

“…HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse,…”
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Digit memory of grand experts in abacus-derived mental calculation by Hatano, G, Osawa, K

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Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop by Cale, Evan M., Gorman, Jason, Radakovich, Nathan A., Crooks, Ema T., Osawa, Keiko, Tong, Tommy, Li, Jiaqi, Nagarajan, Raju, Ozorowski, Gabriel, Ambrozak, David R., Asokan, Mangai, Bailer, Robert T., Bennici, Anthony K., Chen, Xuejun, Doria-Rose, Nicole A., Druz, Aliaksandr, Feng, Yu, Joyce, M. Gordon, Louder, Mark K., O’Dell, Sijy, Oliver, Courtney, Pancera, Marie, Connors, Mark, Hope, Thomas J., Kepler, Thomas B., Wyatt, Richard T., Ward, Andrew B., Georgiev, Ivelin S., Kwong, Peter D., Mascola, John R., Binley, James M.

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Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site: e1004932 by Crooks, Ema T, Tong, Tommy, Chakrabarti, Bimal, Narayan, Kristin, Georgiev, Ivelin S, Menis, Sergey, Huang, Xiaoxing, Kulp, Daniel, Osawa, Keiko, Muranaka, Janelle, Stewart-Jones, Guillaume, Destefano, Joanne, O'Dell, Sijy, LaBranche, Celia, Robinson, James E, Montefiori, David C, McKee, Krisha, Du, Sean X, Doria-Rose, Nicole, Kwong, Peter D, Mascola, John R, Zhu, Ping, Schief, William R, Wyatt, Richard T, Whalen, Robert G, Binley, James M

“…Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed…”
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KS-505a, a novel inhibitor of bovine brain Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase from Streptomyces argenteolus by Nakanishi, S, Osawa, K, Saito, Y, Kawamoto, I, Kuroda, K, Kase, H

“…A novel compound, KS-505a was isolated from the culture broth of a strain identified as Streptomyces argenteolus A-2. The compound inhibited bovine brain Ca2+…”
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Evidence for an Increased Intracellular Free CalciumConcentration in Platelets of Bronchial Asthma Patients by KURODA, Shigeomi, ISHIKAWA, Kazuhiko, HANAMITSU, Hiroshi, KOMORI, Masaki, KOMIYA, Kayoko, ICHIKAWA, Yumiko, MAEJIMA, Kiyoshi, HASEGAWA, Keika, NINOMIYA, Rumiko, KURODA, Mari, NAGAMATSU, Kazuyuki, OSAWA, Keiko, IMAEDA, Kazuo

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Multi-parameter exploration of HIV-1 virus-like particles as neutralizing antibody immunogens in guinea pigs, rabbits and macaques by Tong, Tommy, Crooks, Ema T, Osawa, Keiko, Robinson, James E, Barnes, Mary, Apetrei, Cristian, Binley, James M

“…Virus-like particles (VLPs) offer a platform to test the hypothesis that, since antibody binding to native envelope glycoprotein (Env) trimers results in HIV-1…”
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